{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:41Z","timestamp":1791118421508,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Esophageal squamous cell carcinoma (ESCC) usually affects the upper or middle esophagus and is strongly associated with tobacco and alcohol use. We report a 28-year-old woman with longstanding celiac disease who presented with progressive dysphagia, weight loss, retrosternal pain, and melena. Endoscopy showed a partially obstructing distal esophageal mass; biopsy confirmed moderately differentiated keratinizing ESCC, while duodenal biopsy showed active celiac disease. CT and PET imaging revealed regional lymphadenopathy without distant metastasis. She underwent feeding jejunostomy, nutritional support, and neoadjuvant chemoradiotherapy, but follow-up imaging showed interval disease progression. The patient\u2019s young age, squamous cell histology in a distal esophagus, and the absence of conventional risk factors make this an unusual presentation. This case emphasizes the need for high clinical suspicion and early endoscopic evaluation in young patients with celiac disease presenting with alarming symptoms, even in the absence of classic risk factors for esophageal cancer.<\/jats:p>","DOI":"10.1093\/omcr\/omag178","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:20:30Z","timestamp":1789384830000},"source":"Crossref","is-referenced-by-count":0,"title":["Keratinizing squamous cell carcinoma of the distal Esophagus in a young adult woman with celiac disease: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8237-9080","authenticated-orcid":false,"given":"Samiullah","family":"Shaikh","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, Internal Medicine Department , 2651 E Discovery Pkwy, Bloomington, IN, 47401 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5008-7786","authenticated-orcid":false,"given":"Sidra","family":"Samad","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences , Jamshoro ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0937-7204","authenticated-orcid":false,"given":"Muhammad","family":"Saad","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences , Jamshoro ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7120-8629","authenticated-orcid":false,"given":"Areeba Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Services Institute of Medical Sciences , Lahore ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizan","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Indiana University Health Bloomington Hospital , Bloomington, IN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4441-6547","authenticated-orcid":false,"given":"Riaz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Liaquat University of Medical and Health Sciences , Jamshoro ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8208-0689","authenticated-orcid":false,"given":"Kamil Ahmad","family":"Kamil","sequence":"additional","affiliation":[{"name":"Mirwais Regional Hospital , Kandahar 3801 ,","place":["Afghanistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"2026100408214573400_ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2026100408214573400_ref2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1136\/gutjnl-2014-308124","article-title":"Global incidence of oesophageal cancer by histological subtype in 2012","volume":"64","author":"Arnold","year":"2015","journal-title":"Gut"},{"key":"2026100408214573400_ref3","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1053\/j.gastro.2017.08.023","article-title":"Epidemiology of esophageal squamous cell carcinoma","volume":"154","author":"Abnet","year":"2018","journal-title":"Gastroenterology"},{"key":"2026100408214573400_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001612","article-title":"Association between coeliac disease and risk of any malignancy and gastrointestinal malignancy: a meta-analysis","volume":"94","author":"Han","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"2026100408214573400_ref5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.12669\/pjms.40.1.7419","article-title":"Epidemiological and clinical characteristics of esophageal carcinoma: an experience from tertiary care hospital of Karachi, Pakistan. 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