{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:06Z","timestamp":1791118386847,"version":"4.1.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Celiac disease (CD) can present solely with atypical extra-intestinal symptoms. We describe a 33-year-old woman hospitalized for a one-month history of fever, myalgias, and tachycardia. Extensive infectious, autoimmune, and malignancy investigations were unrevealing. However, hypochromic anemia and elevated CRP prompted serologic testing, revealing positive anti-transglutaminase IgA. Duodenal biopsy confirmed CD with Marsh IIIa villous atrophy. This case illustrates CD as a rare etiology of fever of unknown origin (FUO), emphasizing the importance of celiac serology in the differential diagnosis of prolonged unexplained fever.<\/jats:p>","DOI":"10.1093\/omcr\/omag180","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:14:33Z","timestamp":1789384473000},"source":"Crossref","is-referenced-by-count":0,"title":["Pyrexia as the primary paradox: celiac disease masked as fever of unknown origin"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-1508","authenticated-orcid":false,"given":"Soufiane","family":"Abdouh","sequence":"first","affiliation":[{"name":"Primary Care Physician , Marrakesh Medina, 40000 ,","place":["Kingdom of Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1628-2850","authenticated-orcid":false,"given":"Imane","family":"Boujguenna","sequence":"additional","affiliation":[{"name":"Pathologist, Faculty of Medicine and Pharmacy , Guelmim 81000 ,","place":["Kingdom of Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soukaina","family":"Oumlil","sequence":"additional","affiliation":[{"name":"Internal Medicine Specialist , Agadir 81000 ,","place":["Kingdom of Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"2026100408214191300_ref1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/medicina62010120","article-title":"Unraveling the complexity of celiac disease: a narrative review of its multisystem nature","volume":"62","author":"Rogalidou","year":"2026","journal-title":"Medicina (Kaunas)"},{"key":"2026100408214191300_ref2","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026100408214191300_ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/MCG.0000000000001267","article-title":"Celiac disease: Extraintestinal manifestations and associated conditions","volume":"54","author":"Therrien","year":"2020","journal-title":"J Clin Gastroenterol"},{"key":"2026100408214191300_ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/676327","article-title":"Celiac disease presenting as fever of unknown origin","volume":"2013","author":"Cooney","year":"2013","journal-title":"Case Rep Gastrointest Med"},{"key":"2026100408214191300_ref5","doi-asserted-by":"publisher","DOI":"10.29089\/2017.17.00034","article-title":"Celiac disease presenting as fever of unknown origin in the adult: the role of undiagnosed celiac disease in systemic atherosclerosis","volume":"25","author":"Cioni","year":"2018","journal-title":"Pol Ann Med"},{"key":"2026100408214191300_ref6","doi-asserted-by":"publisher","first-page":"P192","DOI":"10.1186\/1546-0096-13-S1-P192","article-title":"Periodic fevers associated with celiac disease and marked increase of NK cells","volume":"13","author":"Sediva","year":"2015","journal-title":"Pediatr Rheumatol"},{"key":"2026100408214191300_ref7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12969-016-0128-y","article-title":"Macrophage activation syndrome triggered by coeliac disease: a unique case report","volume":"14","author":"Palman","year":"2016","journal-title":"Pediatr Rheumatol"},{"key":"2026100408214191300_ref8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-196102000-00001","article-title":"Fever of unexplained origin: report on 100 cases","volume":"40","author":"Petersdorf","year":"1961","journal-title":"Medicine (Baltimore)"},{"key":"2026100408214191300_ref9","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1056\/NEJMra2111003","article-title":"Fever of unknown origin","volume":"386","author":"Haidar","year":"2022","journal-title":"N Engl J Med"},{"key":"2026100408214191300_ref10","doi-asserted-by":"publisher","first-page":"S294","DOI":"10.1086\/513856","article-title":"Cytokines as endogenous Pyrogens","volume":"179","author":"Dinarello","year":"1999","journal-title":"J Infect Dis"},{"key":"2026100408214191300_ref11","doi-asserted-by":"publisher","first-page":"eaaw7756","DOI":"10.1126\/sciadv.aaw7756","article-title":"Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease","volume":"5","author":"Goel","year":"2019","journal-title":"Sci Adv"},{"key":"2026100408214191300_ref12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1053\/j.gastro.2025.05.022","article-title":"Blood-based T-cell diagnosis of celiac disease","volume":"169","author":"Moscatelli","year":"2025","journal-title":"Gastroenterology."},{"key":"2026100408214191300_ref13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1001\/archinte.163.5.545","article-title":"A comprehensive evidence-based approach to fever of unknown origin","volume":"163","author":"Mourad","year":"2003","journal-title":"Arch Intern Med"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/10\/omag180\/71578538\/omag180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/10\/omag180\/71578538\/omag180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:21:46Z","timestamp":1791116506000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag180\/8860393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,4]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag180","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,10]]},"article-number":"omag180"}}