{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:46:24Z","timestamp":1792255584022,"version":"4.4.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Complex intra-abdominal collections typically present management challenges, with percutaneous drainage remaining the standard of care. Fibrinolytic therapy has limited data for complex intra-abdominal collections despite solid evidence in intrapleural empyema. Here, we report a case of successful fibrinolytic therapy in a patient with persistent intra-abdominal collection. A 57-year-old woman with a history of open Roux-en-Y gastric bypass presented with a perforated marginal ulcer. Following successful surgical management, she developed a recurrent\/persistent intra-abdominal collection that failed several percutaneous drainage attempts. Alteplase was administered through the abdominal drain, resulting in complete resolution of the collection. Despite limited evidence, fibrinolytic therapy for complex abdominal collections appears applicable and safe in selected cases. Further large series and randomized trials are needed to examine its efficacy and cost-effectiveness.<\/jats:p>","DOI":"10.1093\/omcr\/omag197","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:33:33Z","timestamp":1791891213000},"source":"Crossref","is-referenced-by-count":0,"title":["Fibrinolytics in the Management of Complex Abdominal Collections: a case report and review of the literature"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-7871","authenticated-orcid":false,"given":"Sultan","family":"Almuallem","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, King Abdulaziz University , Jeddah 21589 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"2026101712301883900_ref1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1089\/sur.2024.137","article-title":"The surgical infection society guidelines on the Management of Intra-Abdominal Infection: 2024 update","volume":"25","author":"Huston","year":"2024","journal-title":"Surg Infect"},{"key":"2026101712301883900_ref2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13017-021-00387-8","article-title":"WSES\/GAIS\/SIS-E\/WSIS\/AAST global clinical pathways for patients with intra-abdominal infections","volume":"16","author":"Sartelli","year":"2021","journal-title":"World J Emerg Surg"},{"key":"2026101712301883900_ref3","doi-asserted-by":"publisher","first-page":"250131","DOI":"10.1183\/16000617.0131-2025","article-title":"Outcomes of intrapleural fibrinolytic and deoxyribonuclease therapy in pleural infection: a systematic review and meta-analysis","volume":"35","author":"Ferreira de Almeida","year":"2026","journal-title":"Eur Respir Rev"},{"key":"2026101712301883900_ref4","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1055\/s-0044-1781451","article-title":"Fibrinolytic agents in thromboembolic diseases: historical perspectives and approved indications","volume":"50","author":"Rashedi","year":"2024","journal-title":"Semin Thromb Hemost"},{"key":"2026101712301883900_ref5","first-page":"1234","article-title":"Management of abdominal and pelvic abscesses with intracavitary fibrinolytic therapy: a systematic review and meta-analysis","volume":"31","author":"Gervais","year":"2020","journal-title":"J Vasc Interv Radiol"},{"key":"2026101712301883900_ref6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/0846537120914263","article-title":"Use of tissue plasminogen activator in abdominal abscesses in children-a single-Center randomized control trial","volume":"72","author":"Gibson","year":"2021","journal-title":"Can Assoc Radiol J"},{"key":"2026101712301883900_ref7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1590\/0100-3984.2017.0086","article-title":"Minimally invasive treatment of complex collections: safety and efficacy of recombinant tissue plasminogen activator as an adjuvant to percutaneous drainage","volume":"51","author":"Falsarella","year":"2018","journal-title":"Radiol Bras"},{"key":"2026101712301883900_ref8","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jvir.2008.03.007","article-title":"Randomized prospective comparison of alteplase versus saline solution for the percutaneous treatment of loculated abdominopelvic abscesses","volume":"19","author":"Cheng","year":"2008","journal-title":"J Vasc Interv Radiol"},{"key":"2026101712301883900_ref9","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1148\/radiol.2472070761","article-title":"Complex abdominal and pelvic abscesses: efficacy of adjunctive tissue-type plasminogen activator for drainage","volume":"247","author":"Beland","year":"2008","journal-title":"Radiology."},{"key":"2026101712301883900_ref10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.21037\/acr-23-178","article-title":"Use of fibrinolytics for percutaneous drainage of intrabdominal hematoma: a case report","volume":"8","author":"Naqvi","year":"2024","journal-title":"AME Case Rep"}],"container-title":["Oxford Medical Case 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