{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:32:34Z","timestamp":1781659954647,"version":"3.54.5"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myasthenia Gravis (MG) is a chronic autoimmune neuromuscular disease. Although it is well known that patients with myasthenia gravis have a higher incidence of other autoimmune disorders, however, its association with pituitary adenomas is extremely rare. We believe that our case represents the 8th of this association and the 2nd case involving a GH-secreting adenoma. Here we report a case of a 45-year old Syrian woman who presented with typical complaints of myasthenia gravis as she was suffering from variable painless and effort-related dysphagia and dysarthria. Her complaints became more evident at the end of the day, while acromegaly only manifested as a 4-month history of headache and a special facies that was noted by the physician. Brain MRI scan demonstrated a 3.21 x 2.42 x 2.35\u00a0cm pituitary mass for which the patient underwent a trans-sphenoidal pituitary tumor resection. In addition, postoperative histopathological investigations confirmed the diagnosis of a GH-secreting macroadenoma. On following up, it was observed that her myasthenic symptoms improved significantly on Pyridostigmin and Prednisolone. In conclusion, the presence of headache in a myasthenic patient should raise the attention for other underlying causes including pituitary tumors.<\/jats:p>","DOI":"10.1093\/omcr\/omz064","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T10:36:05Z","timestamp":1563446165000},"source":"Crossref","is-referenced-by-count":4,"title":["A Rare Association between Myasthenia Gravis and a Growth Hormone Secreting Pituitary Macroadenoma: A Single Case Report"],"prefix":"10.1093","volume":"2019","author":[{"given":"M T","family":"Farfouti","sequence":"first","affiliation":[{"name":"MRCP (UK), FRCP (London), Department of Neurology, Aleppo University, Faculty of Medicine Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-6325","authenticated-orcid":false,"given":"M","family":"Ghabally","sequence":"additional","affiliation":[{"name":"Medical Student, Aleppo University, Faculty of Medicine, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Roumieh","sequence":"additional","affiliation":[{"name":"Medical Student, Aleppo University, Faculty of Medicine, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Farou","sequence":"additional","affiliation":[{"name":"Medical Student, Aleppo University, Faculty of Medicine, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Shakkour","sequence":"additional","affiliation":[{"name":"Medical Student, Aleppo University, Faculty of Medicine, Aleppo, Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,17]]},"reference":[{"key":"2019071806360521000_ref1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s42000-018-0036-2","article-title":"Myasthenia gravis imitating pituitary apoplexy in macroprolactinoma","volume":"17","author":"Zoli","year":"2018","journal-title":"Hormons"},{"key":"2019071806360521000_ref2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1726-4901(09)70030-9","article-title":"Myasthenia gravis with thymoma and coexistence central hypothyroidism","volume":"72","author":"Yeh","year":"2009","journal-title":"J Chin Med Assoc"},{"key":"2019071806360521000_ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coi.2017.07.006","article-title":"Pathopysiology and immunological profile of myasthenia gravis and its subgroups","volume":"49","author":"Romi","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"2019071806360521000_ref4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/erc.0.0080287","article-title":"Pituitary tumors: pathophysiology, clinical manufestations and management","volume":"8","author":"Arafah","year":"2001","journal-title":"Endocr Relat Cancer"},{"key":"2019071806360521000_ref5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11102-006-0409-4","article-title":"Acromegaly","volume":"9","author":"Scacchi","year":"2006","journal-title":"Pituitary"},{"key":"2019071806360521000_ref6","first-page":"310","article-title":"Prolactin-secreting adenoma in a myasthenic patient","volume":"6","author":"Cahill","year":"1980","journal-title":"Neurosurgery"},{"key":"2019071806360521000_ref7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-0404.2006.00664.x","article-title":"Raiser prolactin levels in myasthenia gravis: two case reports and a study of two patient population","volume":"114","author":"Tsinzerling","year":"2006","journal-title":"Acta Neurol Scand"},{"key":"2019071806360521000_ref8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12020-013-9991-1","article-title":"Concomitant myasthenia gravis and macroprolactinoma: the immunomodulatory role of prolactin and its potential therapeutic use","volume":"45","author":"Harris","year":"2013","journal-title":"Endocrine"},{"key":"2019071806360521000_ref9","first-page":"749","article-title":"Telangiectasic thymoma with myasthenia gravis associated with unusual form of primary microadenoma so-called alveolar adenoepithelioma","volume":"19","author":"Negri","year":"1953","journal-title":"Arch De Vecchi Anat Patol"},{"key":"2019071806360521000_ref10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0022-510X(76)90107-6","article-title":"Thymoma and hypophyseal tumor associated with heterogenous adenomatous proliferation and ganglioneuroma of Sella turcica","volume":"28","author":"Lapresle","year":"1976","journal-title":"J Neurol Sci"},{"key":"2019071806360521000_ref11","first-page":"94","article-title":"Myasthenia gravis: a clinical analysis of the total material from Finland with special references to endocrinological and neurological disorders. PMID: 5399564","volume":"1","author":"Hokkanen","year":"1969","journal-title":"Ann Clin Res"},{"key":"2019071806360521000_ref12","first-page":"490","article-title":"Travaglino Pand Bozzola M. effects of growth hormone (GH) on the immune system","volume":"1","author":"Meazza","year":"2004","journal-title":"Pediatr Endocrinol Rev."}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2019\/7\/omz064\/28939591\/omz064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T10:36:11Z","timestamp":1563446171000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omz064\/5532777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,17]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omz064","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,7,1]]},"article-number":"omz064"}}