{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:19:34Z","timestamp":1771885174182,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sickle \u03b2+-thalassemia rarely manifests with acute splenic sequestration crisis in adults. We report a case of a 20-year-old female who presented with fever and left upper quadrant abdominal pain. Laboratory studies revealed hemolytic anemia. Tests for autoimmune hemolysis and hemolytic diseases were negative except for Hemoglobin (Hb) electrophoresis, which revealed sickle cell trait (Hb AS). Infectious workup was unremarkable. Computed tomography scan of the abdomen showed marked splenomegaly. The patient received blood transfusions and empiric antibiotics with no improvement; thus, splenectomy was performed. Pathology specimen revealed peripheral serpiginous infarcts alternating with surrounding acute inflammation and small capillaries plugged with sickle cell shaped red blood cells consistent with splenic sequestration. DNA test later revealed beta-globin mutations consistent with sickle cell-beta+ thalassemia. Post-splenectomy, there was a gradual improvement in her clinical symptoms with concomitant rise in Hb to 10.6\u00a0g\/dl at discharge.<\/jats:p>","DOI":"10.1093\/omcr\/omz069","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T11:15:52Z","timestamp":1562930152000},"source":"Crossref","is-referenced-by-count":4,"title":["Splenic sequestration crisis as an index manifestation of heterozygous hemoglobinopathy in an adult"],"prefix":"10.1093","volume":"2019","author":[{"given":"Eseosa","family":"Edo-Osagie","sequence":"first","affiliation":[{"name":"Englewood Hospital and Medical Center, Englewood, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikponmwosa","family":"Enofe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University, Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Hakeem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Englewood Hospital and Medical Center, Englewood, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Michigan State University, Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Adomako","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Englewood Hospital and Medical Center, Englewood, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail","family":"Tismenetsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Englewood Hospital and Medical Center, Englewood, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Janosky","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Englewood Hospital and Medical Center, Englewood, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"key":"2019071207154963300_ref1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/10245332.2016.1148893","article-title":"Sickle cell disease in Madhya Pradesh, Central India: a comparison of clinical profile of sickle cell homozygote vs. sickle-beta thalassaemia individuals","volume":"21","author":"Yadav","year":"2016","journal-title":"Hematology"},{"key":"2019071207154963300_ref2","first-page":"375","article-title":"Prevention and control of haemoglobinopathies","volume-title":"Bull. 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A new complication of acute splenic sequestration syndrome","volume":"155","author":"Berry","year":"1991","journal-title":"West J Med"},{"key":"2019071207154963300_ref4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00000441-200503000-00006","article-title":"Fatal splenic sequestration crisis with multiorgan failure in an adult woman with sickle cell-beta+ thalassemia","volume":"329","author":"Aslam","year":"2005","journal-title":"Am J Med Sci"},{"key":"2019071207154963300_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/IJMPCR\/2015\/20027","article-title":"Sickle cell thalassemia: a case report and review of literature","volume":"5","author":"Farara","year":"2015","journal-title":"IJMPCR"},{"key":"2019071207154963300_ref6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/10245332.2016.1187843","article-title":"Sickle cell\/\u03b2-thalassemia: comparison of S\u03b20 and S\u03b2+ Brazilian patients followed at a single institution","volume":"21","author":"Benites","year":"2016","journal-title":"Hematology"},{"key":"2019071207154963300_ref7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00277-006-0125-1","article-title":"Acute splenic sequestration crisis in an adult with sickle beta-thalassemia","volume":"85","author":"Koduri","year":"2006","journal-title":"Ann Hematol"},{"key":"2019071207154963300_ref8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajh.2830180307","article-title":"Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease","volume":"18","author":"Sears","year":"1985","journal-title":"Am J Hematol"},{"key":"2019071207154963300_ref9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/01.SMJ.0000078682.47398.33","article-title":"Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease","volume":"97","author":"Wang-Gillam","year":"2004","journal-title":"South Med J"},{"key":"2019071207154963300_ref10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0002-9343(86)90649-2","article-title":"Acute splenic sequestration crises in adults with sickle cell disease","volume":"80","author":"Solanki","year":"1986","journal-title":"Am J Med"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2019\/7\/omz069\/28929168\/omz069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T11:15:56Z","timestamp":1562930156000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omz069\/5531396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":10,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,12]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omz069","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,7,1]]},"article-number":"omz069"}}