{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:34Z","timestamp":1753877074203,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaplastic large-cell Lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma that is characterized by an entity of large neoplastic cells labeled by the Ki-1 antibody. It constitutes ~2% of all lymphoid neoplasms and is divided into two main categories: anaplastic large-cell kinase (ALK)+ALCL and ALK\u2013ALCL that is recognized by the absence of ALK expression and mostly affects men at older ages. Thus, in this report we present a rare case of ALK-negative ALCL (ALK\u2013ALCL) that was described and diagnosed in a 13-year-old girl in the mediastinum. Highlighting the rarity of manifestation at younger ages and the importance of using immunohistochemical staining in the differential diagnosis of this lymphoid neoplasm.<\/jats:p>","DOI":"10.1093\/omcr\/omz077","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T17:54:26Z","timestamp":1567014866000},"source":"Crossref","is-referenced-by-count":1,"title":["Pediatric mediastinal ALK- negative anaplastic large cell lymphoma (Hodgkin-like pattern) in a 13-year-old girl: a case report and review of literature"],"prefix":"10.1093","volume":"2019","author":[{"given":"Sawsan","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Haydar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatrics and Obstetrics Hospital, Lattakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulmoniem","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulman","family":"Alkadi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuheir","family":"Al-Shehabi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Tishreen University, Lattakia, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"2019091013221547000_ref1","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/cncr.10396","article-title":"A population-based study of pediatric anaplastic 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