{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:18:10Z","timestamp":1760300290964,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a high mortality and poor response to treatment in the advanced setting. Human epidermal growth factor 2 (HER2) can be amplified in a fraction of SDC. We describe the case of HER2+ metastatic SDC of the submandibular gland in a young pregnant woman treated by multimodal treatment (chemotherapy, radiotherapy and targeted therapy). During pregnancy, a 27-year-old woman developed SDC of the left submandibular gland with lung and bone metastases. Given the HER2 overexpression, she was treated with trastuzumab, paclitaxel and cisplatin. Since the tumor had arisen during pregnancy, triptorelin was administered after delivery. A complete remission was observed, and after eight cycles of chemotherapy, radiotherapy was started in association with trastuzumab and triptorelin. A prolonged disease control and complete visceral remission were observed. Multimodal therapy based on patient\u2019s tumor characteristics showed good clinical efficacy in the treatment of metastatic SDC.<\/jats:p>","DOI":"10.1093\/omcr\/omz102","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T14:49:55Z","timestamp":1572533395000},"source":"Crossref","is-referenced-by-count":6,"title":["Treatment of HER2+ metastatic salivary ductal carcinoma in a pregnant woman: a case report"],"prefix":"10.1093","volume":"2019","author":[{"given":"Cristiana","family":"Bergamini","sequence":"first","affiliation":[{"name":"Head & Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Cavalieri","sequence":"additional","affiliation":[{"name":"Head & Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Sanguineti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Farneti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Licitra","sequence":"additional","affiliation":[{"name":"Head & Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"2019103110493107200_ref1","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1002\/cncr.21116","article-title":"Clinical and immunohistologic typing of salivary duct carcinoma: a report of 50 cases","volume":"103","author":"Jaehne","year":"2005","journal-title":"Cancer"},{"key":"2019103110493107200_ref2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0278-2391(10)80263-0","article-title":"Salivary duct carcinoma: a report of nine cases","volume":"51","author":"Colmenero Ruiz","year":"1993","journal-title":"J Oral Maxillofac Surg"},{"key":"2019103110493107200_ref3","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/PAS.0b013e3180caa099","article-title":"Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients","volume":"31","author":"Williams","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"2019103110493107200_ref4","first-page":"1","article-title":"Cyclophosphamide, doxorubicin, and cisplatin in advanced salivary gland cancer","volume":"7","author":"Debaere","year":"2011","journal-title":"B-ENT"},{"key":"2019103110493107200_ref5","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1007\/s12105-013-0456-x","article-title":"Salivary duct carcinoma: new developments--morphological variants including pure in situ high grade lesions; 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