{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:59:10Z","timestamp":1788274750708,"version":"build-2803163510"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a woman presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia.<\/jats:p>","DOI":"10.1093\/omcr\/omz125","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T09:25:09Z","timestamp":1585560309000},"source":"Crossref","is-referenced-by-count":4,"title":["Coombs-positive Paroxysmal Nocturnal Haemoglobinuria"],"prefix":"10.1093","volume":"2020","author":[{"given":"Sabrina","family":"Kalam","sequence":"first","affiliation":[{"name":"Department of Neurology, Charing Cross Hospital, London, W6 8RF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Beale","sequence":"first","affiliation":[{"name":"Department of Nephrology, Royal Free Hospital, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derralynn","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Haematology, Royal Free Hospital, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Kulasekararaj","sequence":"first","affiliation":[{"name":"Department of Haematology, King\u2019s College Hospital, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umasuthan","family":"Srirangalingam","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University College London Hospital, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"2020033005250284600_ref1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","article-title":"Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria","volume":"73","author":"Takeda","year":"1993","journal-title":"Cell."},{"key":"2020033005250284600_ref2","doi-asserted-by":"crossref","DOI":"10.1111\/imj.13160","article-title":"Changing prognosis in Paroxysmal Nocturnal Haemoglobinuria disease subcategories; an analysis of International PNH Registry","author":"Socie","year":"2016","journal-title":"Intern Med J."},{"key":"2020033005250284600_ref3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/sj.leu.2403678","article-title":"Differential gene expression in hematopoietic progenitors from paroxysmal nocturnal hemoglobinuria patients reveals an apoptosis\/immune response in \u2018normal\u2019 phenotype cells","volume":"19","author":"Chen","year":"2005","journal-title":"Leukemia."},{"key":"2020033005250284600_ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1179\/102453309X385089","article-title":"Abnormalities in the expression of CD55 and CD59 surface molecules on peripheral blood cells are not specific to paroxysmal nocturnal hemoglobinuria","volume":"14","author":"Ruiz-Delgado","year":"2009","journal-title":"Hematology."},{"key":"2020033005250284600_ref5","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa061648","article-title":"The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria","volume":"355","author":"Hillmen","year":"2006","journal-title":"The New England journal of medicine."},{"key":"2020033005250284600_ref6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1600-0609.1999.tb01914.x","article-title":"Autoimmune haemolytic anaemia with a paroxysmal nocturnal haemoglobinuria-like defect","volume":"62","author":"\u017cupa\u0144ska","year":"2009","journal-title":"European Journal of Haematology"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2020\/3\/omz125\/32979534\/omz125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/omcr\/article-pdf\/2020\/3\/omz125\/32979534\/omz125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T09:25:11Z","timestamp":1585560311000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omz125\/5813555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,1]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omz125","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,3,1]]},"article-number":"omz125"}}