{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:53Z","timestamp":1787009453535,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autoantibodies to leucine-rich glioma-inactivated protein 1 (LGI-1) are associated with inflammation of the limbic system. Faciobrachial dystonic seizures are pathognomonic for LGI1-antibiodies and their treatment with immunotherapy is effective in seizure control with a potential to prevent cognitive decline. We report a 57-year-old man who presented to the emergency department with recurrent seizures, visual hallucinations and severe memory impairment over a seven-week period; he reported a background of alcohol excess. Initial investigations revealed hyponatremia, indicating syndrome of inappropriate anti-diuretic hormone secretion. Magnetic resonance imaging of the brain revealed bilateral asymmetrical high-T2 and low-T1 signal in the medial temporal lobes. Serum immunofluorescence assay tested positive for LGI-1 antibody. Patient responded to treatment with levetiracetam, intravenous methylprednisolone and five plasma exchange sessions. Patient remains on a maintenance dose of prednisolone and azathioprine. It is imperative that clinicians recognize signs of autoimmune encephalitis in order to curb long-term sequelae and improve clinical outcomes.<\/jats:p>","DOI":"10.1093\/omcr\/omz136","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T05:13:09Z","timestamp":1580706789000},"source":"Crossref","is-referenced-by-count":6,"title":["Leucine-rich glioma-inactivated protein 1 (LGI-1) mediated limbic encephalitis associated with syndrome of inappropriate antidiuretic hormone secretion: a case report"],"prefix":"10.1093","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8443-4401","authenticated-orcid":false,"given":"Emily","family":"Whiles","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, North West Anglia Trust, Peterborough City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-6520","authenticated-orcid":false,"given":"Hareesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, North West Anglia Trust, Peterborough City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prachi","family":"Prachi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, North West Anglia Trust, Peterborough City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkaiah","family":"Kavuri","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, North West Anglia Trust, Peterborough City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayana V","family":"Sagi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, North West Anglia Trust, Peterborough City Hospital, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"2020020305130281000_ref1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fimmu.2017.00336","article-title":"Adaptive immunity is the key to the understanding of autoimmune and paraneoplastic inflammatory central nervous system disorders","volume":"8","author":"Weissert","year":"2017","journal-title":"Front Immunol"},{"key":"2020020305130281000_ref2","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1708712","article-title":"Antibody-mediated encephalitis","volume":"378","author":"Dalmau","year":"2018","journal-title":"NEJM"},{"key":"2020020305130281000_ref3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1001\/jamaneurol.2016.4226","article-title":"Evaluation of cognitive deficits and structural hippocampal Dmaage in encephalitis with Leucine-rich, Gliom-inactivated 1 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