{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:25:13Z","timestamp":1740140713713,"version":"3.37.3"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Draper Family Fund"},{"name":"Gounder Philanthropic Research Fund"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Palmar and plantar fibromatosis are benign proliferative processes which present as a diffuse thickening or nodules of the hands and\/or feet and may lead to flexion contractures, pain, and functional impairment known as Dupuytren and Ledderhose diseases, respectively. Current treatments are noncurative and associated with significant morbidity. Here, we report on the outcomes of 5 patients with advanced disease, no longer surgical candidates, treated with sorafenib. Sorafenib exhibited an expected safety profile. All 5 patients demonstrated objective responses as evaluated by a decrease in tumor size and\/or tumor cellularity from baseline and all 5 patients reported subjective pain relief and\/or functional improvement. Mechanistically, immunohistochemistry revealed patchy positivity for PDGFR\u03b2, a known target of sorafenib. The outcomes of these 5 patients suggest the safety and efficacy of a relatively well-tolerated oral agent in the treatment of Dupuytren and Ledderhose diseases and suggest the need for future controlled studies.<\/jats:p>","DOI":"10.1093\/oncolo\/oyab050","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T05:00:52Z","timestamp":1641013252000},"page":"e294-e296","source":"Crossref","is-referenced-by-count":3,"title":["Sorafenib in Dupuytren and Ledderhose Disease"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3970-9784","authenticated-orcid":false,"given":"Joshua D","family":"Schoenfeld","sequence":"first","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narasimhan P","family":"Agaram","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Lefkowitz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara M","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Healey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal M","family":"Gounder","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"issue":"1","key":"2022031109011156400_CIT0001","doi-asserted-by":"crossref","first-page":"240e","DOI":"10.1097\/PRS.0000000000002857","article-title":"Evidence-based medicine: options for Dupuytren\u2019s contracture: incise, excise, and dissolve.","volume":"139","author":"Denkler","year":"2017","journal-title":"Plast Reconstr Surg."},{"key":"2022031109011156400_CIT0002","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1479-5876-4-21","article-title":"Clonal analysis of palmar fibromatosis: a study whether palmar fibromatosis is a real tumor.","volume":"4","author":"Wang","year":"2006","journal-title":"J Transl Med."},{"issue":"4","key":"2022031109011156400_CIT0003","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJMoa1101029","article-title":"Wnt signaling and Dupuytren\u2019s disease.","volume":"365","author":"Dolmans","year":"2011","journal-title":"N Engl J Med."},{"issue":"7","key":"2022031109011156400_CIT0004","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/modpathol.3880374","article-title":"Superficial fibromatoses are genetically distinct from deep fibromatoses.","volume":"14","author":"Montgomery","year":"2001","journal-title":"Mod Pathol."},{"issue":"25","key":"2022031109011156400_CIT0005","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1056\/NEJMoa1805052","article-title":"Sorafenib for advanced and refractory desmoid tumors.","volume":"379","author":"Gounder","year":"2018","journal-title":"N Engl J Med."},{"issue":"4","key":"2022031109011156400_CIT0006","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/SLA.0000000000003073","article-title":"Association of MRI T2 signal intensity with desmoid tumor progression during active observation: a retrospective cohort study.","volume":"271","author":"Cassidy","year":"2020","journal-title":"Ann Surg."}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/27\/3\/e294\/42828488\/oyab050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/27\/3\/e294\/42828488\/oyab050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T09:01:59Z","timestamp":1646989319000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/27\/3\/e294\/6532269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,19]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2,19]]},"published-print":{"date-parts":[[2022,3,11]]}},"URL":"https:\/\/doi.org\/10.1093\/oncolo\/oyab050","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"type":"print","value":"1083-7159"},{"type":"electronic","value":"1549-490X"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,2,19]]}}}