{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:15:57Z","timestamp":1789038957475,"version":"build-2803163510"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Melville Trust for the Care and Cure of Cancer"},{"DOI":"10.13039\/501100009187","name":"Mason Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009187","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is a lack of standardized objective and reliable assessment tools for chemotherapy-induced peripheral neuropathy (CIPN). In vivo reflectance confocal microscopy (RCM) imaging offers a non-invasive method to identify peripheral neuropathy markers, namely Meissner\u2019s corpuscles (MC). This study investigated the feasibility and value of RCM in CIPN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods<\/jats:title>\n                  <jats:p>Reflectance confocal microscopy was performed on the fingertip to evaluate MC density in 45 healthy controls and 9 patients with cancer (prior, during, and post-chemotherapy). Quantification was completed by 2 reviewers (one blinded), with maximum MC count\/3 \u00d7 3 mm image reported. Quantitative Sensory Testing (QST; thermal and mechanical detection thresholds), Grooved pegboard test, and patient-reported outcomes measures (PROMS) were conducted for comparison.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In controls (25 females, 20 males; 24-81 years), females exhibited greater mean MC density compared with males (49.9 \u00b1 7.1 vs 30.9 \u00b1 4.2 MC\/3 \u00d7 3 mm; P = .03). Differences existed across age by decade (P &amp;lt; .0001). Meissner\u2019s corpuscle density was correlated with mechanical detection (\u03c1 = \u22120.51), warm detection (\u03c1 = \u22120.47), cold pain (\u03c1 = 0.49) thresholds (P &amp;lt; .01); and completion time on the Grooved pegboard test in both hands (P \u2264 .02). At baseline, patients had reduced MC density vs age and gender-matched controls (P = .03). Longitudinal assessment of MC density revealed significant relationships with QST and PROMS. Inter-rater reliability of MC count showed an intraclass correlation of 0.96 (P &amp;lt; .0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The findings support the clinical utility of RCM in CIPN as it provides meaningful markers of sensory nerve dysfunction. Novel, prospective assessment demonstrated the ability to detect subclinical deficits in patients at risk of CIPN and potential to monitor neuropathy progression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyac106","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T11:17:47Z","timestamp":1652181467000},"page":"e671-e680","source":"Crossref","is-referenced-by-count":8,"title":["The Value of In Vivo Reflectance Confocal Microscopy as an Assessment Tool in Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-1755","authenticated-orcid":false,"given":"Sabrina R","family":"Ramnarine","sequence":"first","affiliation":[{"name":"Clinical Imaging and Medical Physics, Guys\u2019 and St. Thomas\u2019 NHS Foundation Trust , London , UK"},{"name":"Faculty of Life Sciences & Medicine, King\u2019s College London , London , UK"},{"name":"Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M","family":"Dougherty","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine, Division of Anesthesiology, Critical Care and Pain Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Rolke","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Medical Faculty RWTH Aachen University , Aachen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J","family":"Williams","sequence":"additional","affiliation":[{"name":"Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh , Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"Alessi-Fox","sequence":"additional","affiliation":[{"name":"Caliber Imaging and Diagnostics Inc. , Rochester, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Coleman","sequence":"additional","affiliation":[{"name":"Clinical Imaging and Medical Physics, Guys\u2019 and St. Thomas\u2019 NHS Foundation Trust , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Modena and Reggio Emilia , Modena , Italy"},{"name":"Azienda Unit\u00e0 Sanitaria Locale-IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia , Reggio Emilia , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A","family":"Colvin","sequence":"additional","affiliation":[{"name":"Division of Population Health and Genomics, University of Dundee , Dundee , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie T","family":"Fallon","sequence":"additional","affiliation":[{"name":"Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"issue":"12","key":"2022080910393813900_CIT0001","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrneurol.2010.160","article-title":"Chemotherapy-induced peripheral neurotoxicity","volume":"6","author":"Cavaletti","year":"2010","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"2022080910393813900_CIT0002","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/clpt.2011.115","article-title":"Chemotherapy-induced peripheral neuropathy: prevention and 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