{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:21:10Z","timestamp":1792614070968,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K12CA226330"],"award-info":[{"award-number":["K12CA226330"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA19262701"],"award-info":[{"award-number":["R01-CA19262701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA250012"],"award-info":[{"award-number":["R01-CA250012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>In the South African Breast Cancer and HIV Outcomes (SABCHO) study, we previously found that breast cancer patients living with HIV and treated with neoadjuvant chemotherapy achieve lower rates of complete pathologic response than patients without HIV. We now assess the impact of comorbid HIV on receipt of timely and complete neoadjuvant and adjuvant chemotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Since June 2015, the SABCHO study has collected data on women diagnosed with breast cancer at 6 South African hospitals. We selected a sample of participants with stages I-III cancer who received \u22652 doses of neoadjuvant or adjuvant chemotherapy. Data on chemotherapies prescribed and received, filgrastim receipt, and laboratory values measured during treatment were captured from patients\u2019 medical records. We calculated the mean relative dose intensity (RDI) for all prescribed chemotherapies. We tested for association between full regimen RDI and HIV status, using linear regression to control for demographic and clinical covariates, and for association of HIV with laboratory abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 166 participants living with HIV and 159 without HIV did not differ in median chemotherapy RDI: 0.89 (interquartile range (IQR) 0.77-0.95) among those living with HIV and 0.87 (IQR 0.77-0.94) among women without HIV. Patients living with HIV experienced more grade 3+ anemia and leukopenia than those without HIV (anemia: 10.8% vs. 1.9%, P = .001; leukopenia: 8.4% vs. 1.9%, P = .008) and were more likely to receive filgrastim (24.7% vs. 10.7%, P = .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>HIV status did not impact neoadjuvant or adjuvant chemotherapy RDI, although patients with breast cancer living with HIV experienced more myelotoxicity during treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyad056","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T23:17:42Z","timestamp":1679440662000},"page":"e921-e929","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-1166","authenticated-orcid":false,"given":"Daniel S","family":"O\u2019Neil","sequence":"first","affiliation":[{"name":"Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, Yale University , New Haven, CT , USA"},{"name":"Yale Cancer Center, Yale University , New Haven, CT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin A","family":"Ayeni","sequence":"additional","affiliation":[{"name":"Strengthening Oncology Services Research Unit, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"},{"name":"Division of Medical Oncology, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley A","family":"Farrow","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Radiation Oncology, Grey\u2019s Hospital, University of KwaZulu-Natal , Pietermaritzburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong Carl","family":"Chen","sequence":"additional","affiliation":[{"name":"Strengthening Oncology Services Research Unit, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"},{"name":"National Cancer Registry, National Health Laboratory Service , Johannesburg , South Africa"},{"name":"Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Demetriou","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, Faculty of Health Sciences, 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Pietermaritzburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Joffe","sequence":"additional","affiliation":[{"name":"Strengthening Oncology Services Research Unit, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"},{"name":"SAMRC\/Wits Developmental Pathways to Health Research Unit, Department of Paediatrics, Faculty of the Health Sciences, University of the Witwatersrand , Johannesburg , South Africa"},{"name":"South Africa Medical Research Council Common Epithelial Cancers Research Centre, Faculty of Health Sciences, University of Witwatersrand , Johannesburg , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Psychology and Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami , Miami, FL , USA"},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Health System , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Lopes","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, University of Miami Health System , Miami, FL , USA"},{"name":"Department of Medicine, Miller School of Medicine, University of Miami , Miami, FL , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoanna S","family":"Pumpalova","sequence":"additional","affiliation":[{"name":"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center , New York, NY , USA"},{"name":"Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University , New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witness","family":"Mapanga","sequence":"additional","affiliation":[{"name":"Strengthening Oncology Services Research Unit, 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