{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:34:26Z","timestamp":1780914866689,"version":"3.54.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Clinical Trials Network","award":["U10CA180886"],"award-info":[{"award-number":["U10CA180886"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Shortages of curative chemotherapy agents for children and adults with cancer are ubiquitous. These shortages directly result in compromised outcomes, increased medication errors, heightened cost to health systems, and patient deaths. Methotrexate is a staple of many curative childhood cancer regimens and is frequently in scarcity. No national guidance to manage methotrexate and other chemotherapy shortages exists. To assess the effect of the current methotrexate shortage, a multinational survey of Children\u2019s Oncology Group (COG) member institutions was conducted. Wide variation in the scope of methotrexate shortage in the US was demonstrated; some centers experienced significant scarcity while others experienced no shortage. Methotrexate mitigation strategies differed by COG site, resulting in potential to exacerbate differential access to life-saving medication and inequities in care. Preventing chemotherapy shortages remains a challenge. In the interim, standard guidance to assist clinicians to equitably and fairly cope with methotrexate and related drug shortages is needed.<\/jats:p>","DOI":"10.1093\/oncolo\/oyad323","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T10:36:34Z","timestamp":1702118194000},"source":"Crossref","is-referenced-by-count":5,"title":["Methotrexate Scarcity Among Children\u2019s Oncology Group Institutions: Results of a Multinational Survey"],"prefix":"10.1093","volume":"30","author":[{"given":"Sarah","family":"Menig","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Seattle Children\u2019s Hospital , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Militano","sequence":"additional","affiliation":[{"name":"Children\u2019s Oncology Group , Monrovia, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ostrenga","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Mississippi Medical Center, Children\u2019s of Mississippi , Jackson, MS ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Brooke","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Services, Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Lee","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer Research, Seattle Children\u2019s Research Institute , Seattle, WA ,","place":["USA"]},{"name":"Department of Pediatrics, University of Washington , Seattle, WA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2250-300X","authenticated-orcid":false,"given":"Yoram","family":"Unguru","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology, The Herman and Walter Samuelson Children\u2019s Hospital at Sinai , Baltimore, MD ,","place":["USA"]},{"name":"Johns Hopkins Berman Institute of Bioethics , Baltimore, MD ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"2025082923462058200_CIT0001","volume-title":"ASHP drug shortages list","author":"Methotrexate Injection","year":"2023"},{"key":"2025082923462058200_CIT0002","article-title":"Supply of a cancer drug may run out within weeks","volume-title":"The New York Times","author":"Harris","year":"2012"},{"key":"2025082923462058200_CIT0003","article-title":"Drug shortages near an all-time high, leading 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