{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:06:47Z","timestamp":1746529607103,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ontario Ministry of Health and the Ministry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Developing prognostic tools specifically for patients themselves represents an important step in empowering patients to engage in shared decision-making. Incorporating patient-reported outcomes may improve the accuracy of these prognostic tools. We conducted a retrospective population-based study of transplant-ineligible (TIE) patients with multiple myeloma (MM) diagnosed between January 2007 and December 2018. A multivariable Cox regression model was developed to predict the risk of death within 1-year period from the index date. We identified 2356 patients with TIE MM. The following factors were associated with an increased risk of death within 1 year: age\u2005&amp;gt;\u200580 (HR 1.11), history of heart failure (HR 1.52), \u201cCRAB\u201d at diagnosis (HR 1.61), distance to cancer center (HR 1.25), prior radiation (HR 1.48), no proteosome inhibitor\/immunomodulatory therapy usage (HR 1.36), recent emergency department (HR 1.55) or hospitalization (HR 2.13), poor performance status (ECOG 3-4 HR 1.76), and increasing number of severe symptoms (HR 1.56). Model discrimination was high with C-statistic of 0.74, and calibration was very good. To our knowledge, this represents one of the first prognostic models developed in MM incorporating patient-reported outcomes. This survival prognostic tool may improve communication regarding prognosis and shared decision-making among older adults with MM and their health care providers.<\/jats:p>","DOI":"10.1093\/oncolo\/oyae041","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T18:13:43Z","timestamp":1713464023000},"page":"519-526","source":"Crossref","is-referenced-by-count":3,"title":["A Prognostic Survival Model Incorporating Patient-Reported Outcomes for Transplant-Ineligible Patients With Multiple Myeloma"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-1067","authenticated-orcid":false,"given":"Hira","family":"Mian","sequence":"first","affiliation":[{"name":"Department of Oncology, McMaster University , Hamilton, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsien","family":"Seow","sequence":"additional","affiliation":[{"name":"Department of Oncology, McMaster University , Hamilton, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaris K","family":"Balitsky","sequence":"additional","affiliation":[{"name":"Department of Oncology, McMaster University , Hamilton, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto , Toronto, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Gayowsky","sequence":"additional","affiliation":[{"name":"ICES, McMaster University , Hamilton, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Calgary , Calgary, AB , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya M","family":"Wildes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Nebraska Medical Center\/Nebraska Medicine , Omaha, NE , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arleigh","family":"McCurdy","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alissa","family":"Visram","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa , Ottawa, ON , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwindeep","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Edmonton , Edmonton, AB , 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