{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:35:41Z","timestamp":1792892141128,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The incidence of breast and colorectal cancer (CRC) in younger-than-average-age patients is rising and poorly understood. This is the largest study on patients with both cancers who are less than 60 years old and aims to characterize demographic, clinicopathologic, and genetic features and describe therapeutic dilemmas and management strategies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>This is a retrospective medical records review of patients at the University of California San Francisco with both primary breast and CRC before age 60.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-one patients were identified; 41 had detailed medical records. Median age of diagnosis with breast cancer was 43 (range 27-59) and CRC was 50 (28-59). Most were Caucasian (38, 74.5%) and never smokers (23, 56.1%); about half were current alcohol consumers (20, 48.8%) and about one-third had sedentary jobs (14, 34.1%). Average BMI was 25.8 (range: 14-49), and 30% were overweight or obese. Breast was the first cancer diagnosed in 36 patients (70.6%) and 44 (86.3%) had a metachronous CRC diagnosis. Breast cancer was early stage (0-2) in 32 (78.0%) patients whereas CRC was split between early stage (1-2) in 14 (34.1%) and later stage (3-4) in 19 (46.2%). Ten patients (24.3%) had a known germline mutation, although 23 (56.1%) had a family history of cancer in a first-degree relative.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Younger patients with both breast and CRC are a unique cohort, often without known risk factors. Alcohol consumption and sedentary jobs were the most common risk factors, and about one-quarter had a known genetic predisposition. Comanagement of both cancers requires individualized, multidisciplinary care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyae114","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T13:47:51Z","timestamp":1718027271000},"page":"e1159-e1168","source":"Crossref","is-referenced-by-count":3,"title":["Synchronous or metachronous breast and colorectal cancers in younger-than-average-age patients: a case series"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-7145","authenticated-orcid":false,"given":"Jordyn","family":"Silverstein","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, San Francisco (UCSF) , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, San Francisco , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Stanfield","sequence":"additional","affiliation":[{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Jo","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, San Francisco (UCSF) , San Francisco, CA 94143 , United States"},{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine M","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, UCSF , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, San Francisco (UCSF) , San Francisco, CA 94143 , United States"},{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amie","family":"Blanco","sequence":"additional","affiliation":[{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"},{"name":"Cancer Genetics and Prevention Program, UCSF , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-4114","authenticated-orcid":false,"given":"Katherine","family":"Van Loon","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, San Francisco (UCSF) , San Francisco, CA 94143 , United States"},{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe E","family":"Atreya","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of California, San Francisco (UCSF) , San Francisco, CA 94143 , United States"},{"name":"UCSF Helen Diller Family Comprehensive Cancer Center , San Francisco, CA 94143 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"1","key":"2024090704205628400_CIT0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"2024090704205628400_CIT0002","article-title":"Cancer of the breast (female) - Cancer Stat Facts"},{"key":"2024090704205628400_CIT0003","article-title":"Cancer of the colon and rectum - Cancer Stat Facts"},{"issue":"2","key":"2024090704205628400_CIT0004","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/cncr.33916","article-title":"Trends in the incidence of early-onset colorectal cancer in all 50 United States from 2001 through 2017","volume":"128","author":"Shah","year":"2022","journal-title":"Cancer"},{"issue":"8","key":"2024090704205628400_CIT0005","doi-asserted-by":"crossref","first-page":"e1027","DOI":"10.1016\/S2214-109X(20)30215-1","article-title":"Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study","volume":"8","author":"Heer","year":"2020","journal-title":"Lancet Glob Health"},{"issue":"8","key":"2024090704205628400_CIT0006","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4251\/wjgo.v13.i8.856","article-title":"Young-onset colorectal cancer: a review","volume":"13","author":"Done","year":"2021","journal-title":"World J Gastrointest Oncol"},{"issue":"10","key":"2024090704205628400_CIT0007","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41571-022-00672-8","article-title":"Is early-onset cancer an emerging global epidemic? Current evidence and future implications","volume":"19","author":"Ugai","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"2024090704205628400_CIT0008","doi-asserted-by":"crossref","first-page":"e2328171","DOI":"10.1001\/jamanetworkopen.2023.28171","article-title":"Patterns in cancer incidence among people younger than 50 years in the US, 2010 to 2019","volume":"6","author":"Koh","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"2","key":"2024090704205628400_CIT0009","doi-asserted-by":"crossref","first-page":"e000172","DOI":"10.1136\/esmoopen-2017-000172","article-title":"Multiple primary tumours: challenges and approaches, a review","volume":"2","author":"Vogt","year":"2017","journal-title":"ESMO Open"},{"issue":"1","key":"2024090704205628400_CIT0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1245\/s10434-011-1843-8","article-title":"Outcomes for patients who develop both breast and colorectal cancer","volume":"19","author":"Fisher","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"2024090704205628400_CIT0011","doi-asserted-by":"crossref","first-page":"e232680","DOI":"10.1136\/bcr-2019-232680","article-title":"Synchronous breast and colon cancer: the importance of multidisciplinary team cancer meetings","volume":"12","author":"Abdulla","year":"2019","journal-title":"BMJ Case Rep"},{"issue":"2","key":"2024090704205628400_CIT0012","first-page":"e1","article-title":"The rare diagnosis of synchronous breast and colonic cancers: a case report and review of literature","volume":"13","author":"Asaad","year":"3314","journal-title":"Cureus"},{"issue":"2","key":"2024090704205628400_CIT0013","first-page":"1","article-title":"Synchronous occurrence of primary breast carcinoma and primary colon adenocarcinoma","volume":"2017","author":"Yetkin","year":"2017","journal-title":"Case Rep Surg"},{"issue":"12","key":"2024090704205628400_CIT0014","doi-asserted-by":"crossref","first-page":"bcr2013009450","DOI":"10.1136\/bcr-2013-009450","article-title":"Synchronous breast and colon cancer: factors determining treatment strategy. Case reports","volume":"2013","author":"Higgins","year":"2013","journal-title":"BMJ Case Rep"},{"issue":"2","key":"2024090704205628400_CIT0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10620-021-07296-5","article-title":"Coincidental or causal? Concurrence of colorectal carcinoma with primary breast cancer","volume":"67","author":"Tripodi","year":"2021","journal-title":"Dig Dis Sci"},{"issue":"11-12","key":"2024090704205628400_CIT0016","first-page":"409","article-title":"Synchronous primary malignant tumors of the breast, caecum and sigma. Case report","volume":"33","author":"Anania","year":"2012","journal-title":"G Chir"},{"issue":"3","key":"2024090704205628400_CIT0017","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3393\/ac.2021.00640.0091","article-title":"Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer","volume":"38","author":"Lee","year":"2021","journal-title":"Ann Coloproctol"},{"key":"2024090704205628400_CIT0018","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.canep.2016.01.006","article-title":"Increased risk of colorectal cancer in patients diagnosed with breast cancer in women","volume":"41","author":"Lu","year":"2016","journal-title":"Cancer Epidemiol"},{"issue":"4","key":"2024090704205628400_CIT0019","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.18203\/2349-2902.isj20211317","article-title":"Synchronous breast and colon cancer in a young female: a single stage surgery","volume":"8","author":"Abushwemeh","year":"2021","journal-title":"Int Surg J"},{"issue":"5","key":"2024090704205628400_CIT0020","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1086\/375121","article-title":"The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype","volume":"72","author":"Meijers-Heijboer","year":"2003","journal-title":"Am J Hum Genet"},{"issue":"2","key":"2024090704205628400_CIT0021","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/1878-0261.12417","article-title":"Early-onset colorectal cancer in young individuals","volume":"13","author":"Mauri","year":"2019","journal-title":"Mol Oncol"},{"issue":"6","key":"2024090704205628400_CIT0022","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/acer.13071","article-title":"Alcohol use and breast cancer: a critical review","volume":"40","author":"Shield","year":"2016","journal-title":"Alcohol Clin Exp Res"},{"issue":"9","key":"2024090704205628400_CIT0023","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1093\/annonc\/mdq653","article-title":"Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies","volume":"22","author":"Fedirko","year":"2011","journal-title":"Ann Oncol"},{"issue":"17","key":"2024090704205628400_CIT0024","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1001\/jama.2011.1590","article-title":"Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk","volume":"306","author":"Chen","year":"2011","journal-title":"JAMA"},{"issue":"1","key":"2024090704205628400_CIT0025","doi-asserted-by":"crossref","first-page":"1073274820976670","DOI":"10.1177\/1073274820976670","article-title":"Risk factors associated with young-onset colorectal adenomas and cancer: a systematic review and meta-analysis of observational research","volume":"27","author":"Breau","year":"2020","journal-title":"Cancer Control"},{"issue":"10","key":"2024090704205628400_CIT0026","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/aje\/kwq513","article-title":"Long-term sedentary work and the risk of subsite-specific colorectal cancer","volume":"173","author":"Boyle","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"1","key":"2024090704205628400_CIT0027","doi-asserted-by":"crossref","first-page":"e12239","DOI":"10.1002\/1348-9585.12239","article-title":"Sedentary work and breast cancer risk: a systematic review and meta-analysis","volume":"63","author":"Lee","year":"2021","journal-title":"J Occup Health"},{"issue":"6","key":"2024090704205628400_CIT0028","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cgh.2021.01.037","article-title":"Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis","volume":"20","author":"O'Sullivan","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"2024090704205628400_CIT0029","doi-asserted-by":"crossref","first-page":"pky073","DOI":"10.1093\/jncics\/pky073","article-title":"Sedentary behaviors, TV viewing time, and risk of young-onset colorectal cancer","volume":"2","author":"Nguyen","year":"2018","journal-title":"JNCI Cancer Spectr"},{"issue":"11","key":"2024090704205628400_CIT0030","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s10552-019-01223-w","article-title":"World cancer research fund international: continuous update project-systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk","volume":"30","author":"Chan","year":"2019","journal-title":"Cancer Causes Control"},{"issue":"5","key":"2024090704205628400_CIT0031","doi-asserted-by":"crossref","first-page":"e19657","DOI":"10.1371\/journal.pone.0019657","article-title":"Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity","volume":"6","author":"Church","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"2024090704205628400_CIT0032","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jamaoncol.2018.4280","article-title":"Association of obesity with risk of early-onset colorectal cancer among women","volume":"5","author":"Liu","year":"2019","journal-title":"JAMA Oncol"},{"issue":"17","key":"2024090704205628400_CIT0033","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jama.1997.03550170037029","article-title":"Dual effects of weight and weight gain on breast cancer risk","volume":"278","author":"Huang","year":"1997","journal-title":"JAMA"},{"issue":"1","key":"2024090704205628400_CIT0034","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13058-018-1056-1","article-title":"Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC)","volume":"20","author":"Hopper","year":"2018","journal-title":"Breast Cancer Res"},{"key":"2024090704205628400_CIT0035","volume-title":"Continuous update project report summary. Diet, nutrition, physical activity, and breast cancer","year":"2017"},{"issue":"6","key":"2024090704205628400_CIT0036","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/jamaoncol.2018.0125","article-title":"Obesity, Body composition, and breast cancer: An evolving science","volume":"4","author":"Bandera","year":"2018","journal-title":"JAMA Oncol"},{"issue":"1","key":"2024090704205628400_CIT0037","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/CEJ.0000000000000667","article-title":"Inflammatory bowel disease and risk of breast cancer: a meta-analysis of cohort studies","volume":"31","author":"Gong","year":"2022","journal-title":"Eur J Cancer Prev"},{"issue":"10218","key":"2024090704205628400_CIT0038","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study","volume":"395","author":"Ol\u00e9n","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"2024090704205628400_CIT0039","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2468-1253(20)30005-4","article-title":"Colorectal cancer in Crohn\u2019s disease: a Scandinavian population-based cohort study","volume":"5","author":"Ol\u00e9n","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"3","key":"2024090704205628400_CIT0040","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/genes12030372","article-title":"The unique biology behind the early onset of breast cancer","volume":"12","author":"Siddig","year":"2021","journal-title":"Genes (Basel)"},{"issue":"8","key":"2024090704205628400_CIT0041","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/gim.2014.176","article-title":"Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1\/2-negative patients with early-onset breast cancer","volume":"17","author":"Maxwell","year":"2015","journal-title":"Genet Med"},{"issue":"1","key":"2024090704205628400_CIT0042","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jamaoncol.2018.2956","article-title":"Association of breast and ovarian cancers with predisposition genes identified by large-scale sequencing","volume":"5","author":"Lu","year":"2019","journal-title":"JAMA Oncol"},{"issue":"3","key":"2024090704205628400_CIT0043","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/cells10030710","article-title":"The inherited and familial component of early-onset colorectal cancer","volume":"10","author":"Daca Alvarez","year":"2021","journal-title":"Cells"},{"issue":"6","key":"2024090704205628400_CIT0044","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.amepre.2017.07.016","article-title":"Low prevalence of criteria for early screening in young-onset colorectal cancer","volume":"53","author":"Chen","year":"2017","journal-title":"Am J Prev Med"},{"issue":"4","key":"2024090704205628400_CIT0045","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1053\/j.gastro.2017.11.004","article-title":"Germline genetic features of young individuals with colorectal cancer","volume":"154","author":"Stoffel","year":"2018","journal-title":"Gastroenterology"},{"issue":"9291","key":"2024090704205628400_CIT0046","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(01)06524-2","article-title":"Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease","volume":"358","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"2001","journal-title":"Lancet"},{"issue":"1","key":"2024090704205628400_CIT0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41698-023-00353-4","article-title":"Survival improvement for patients with metastatic colorectal cancer over twenty years","volume":"7","author":"Zeineddine","year":"2023","journal-title":"NPJ Precis Onc"},{"issue":"100573","key":"2024090704205628400_CIT0048","article-title":"Real-world time trends in overall survival, treatments and patient characteristics in HR+\/HER2\u2212 metastatic breast cancer: an observational study of the SONABRE Registry","volume":"26","author":"Meegdes","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"2024090704205628400_CIT0049","article-title":"Breast cancer - metastatic - statistics","year":"2017"},{"issue":"4","key":"2024090704205628400_CIT0050","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3390\/cancers14041048","article-title":"Association between prior malignancy exclusion criteria and age disparities in cancer clinical trials","volume":"14","author":"Patel","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"11","key":"2024090704205628400_CIT0051","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1054\/bjoc.2001.1819","article-title":"Oral fluoropyrimidines among the new drugs for patients with metastatic breast cancer","volume":"84","author":"Leonard","year":"2001","journal-title":"Br J Cancer"},{"issue":"6","key":"2024090704205628400_CIT0052","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3322\/caac.21204","article-title":"Chemotherapy-induced peripheral neurotoxicity: a critical analysis","volume":"63","author":"Park","year":"2013","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"2024090704205628400_CIT0053","doi-asserted-by":"crossref","first-page":"e2036695","DOI":"10.1001\/jamanetworkopen.2020.36695","article-title":"Hemoglobin, body mass index, and age as risk factors for paclitaxel- and oxaliplatin-induced peripheral neuropathy","volume":"4","author":"Mizrahi","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"1","key":"2024090704205628400_CIT0054","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1529-8027.2008.00156.x","article-title":"Chemotherapy-induced neuropathy","volume":"13","author":"Windebank","year":"2008","journal-title":"J Peripher Nerv Syst"},{"issue":"9869","key":"2024090704205628400_CIT0055","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0140-6736(12)61963-1","article-title":"Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial","volume":"381","author":"Davies","year":"2013","journal-title":"Lancet"},{"issue":"3 Suppl","key":"2024090704205628400_CIT0056","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/cncr.23189","article-title":"Combining endocrine agents with chemotherapy: Which patients and what sequence","volume":"112","author":"Pritchard","year":"2008","journal-title":"Cancer"},{"issue":"7","key":"2024090704205628400_CIT0057","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1182\/blood-2015-01-625582","article-title":"When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English health care data","volume":"127","author":"Walker","year":"2016","journal-title":"Blood"},{"issue":"5","key":"2024090704205628400_CIT0058","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/jamaoncol.2021.8196","article-title":"Diagnosis and treatment of ERBB2-positive metastatic colorectal cancer: a review","volume":"8","author":"Strickler","year":"2022","journal-title":"JAMA Oncol"},{"issue":"6","key":"2024090704205628400_CIT0059","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1081\/CNV-200039645","article-title":"Low overexpression of HER-2\/Neu in advanced colorectal cancer limits the usefulness of trastuzumab (Herceptin\u00ae) and irinotecan as therapy. a phase II trial","volume":"22","author":"Ramanathan","year":"2004","journal-title":"Cancer Invest"},{"key":"2024090704205628400_CIT0060","article-title":"Research C for DE and. FDA grants accelerated approval to tucatinib with trastuzumab for colorectal cancer","year":"2023","journal-title":"FDA"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/29\/9\/e1159\/59036707\/oyae114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/29\/9\/e1159\/59036707\/oyae114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T05:04:35Z","timestamp":1725685475000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/29\/9\/e1159\/7690456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,6,10]]},"published-print":{"date-parts":[[2024,9,6]]}},"URL":"https:\/\/doi.org\/10.1093\/oncolo\/oyae114","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,6,10]]}}}