{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T07:24:47Z","timestamp":1769930687213,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004802","name":"California Breast Cancer Research Program","doi-asserted-by":"publisher","award":["B26TR1481"],"award-info":[{"award-number":["B26TR1481"]}],"id":[{"id":"10.13039\/100004802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Little information exists on adverse effects related to opioid use in breast cancer survivors following active cancer treatment, and no studies included an age-matched comparison group. Thus, we examined opioid use and risk of falls, fractures, lung problems, and cardiovascular events in breast cancer survivors in the years following active cancer treatment along with a comparison group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a longitudinal cohort study 33\u00a0989 breast cancer survivors and 157\u00a0609 age-matched women without cancer. Rates of adverse events, and multivariable hazards ratios for association between opioid use and the adverse health effects were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Women with breast cancer had greater opioid use (60% vs 48%); longer median opioid duration (18 vs 16 days); and were prescribed stronger opioids than the matched cohort over 5.6 median years of follow-up. In multivariable models, the risk of falls was 12% higher (HR, 95% CI, 1.12 [1.07-1.17]), and fracture risk was 56% (HR = 1.56 [1.48-1.65]) greater in women with breast cancer who used opioids vs the matched cohort unexposed to opioids. In an analysis restricted to women with breast cancer, opioid use was strongly associated with the risk of falls (HR = 1.74 [1.63-1.85]); fractures (HR = 2.10 [1.95-2.27]); lung problems (HR = 1.53 [1.43-1.64]); and cardiovascular events (HR = 1.70 [1.39-2.08]) than opioid non-use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>After active cancer treatment, opioid use and high dosage use were common in breast cancer survivors, and were associated with increased risk for falls, lung problems, fractures, and cardiovascular events. Findings underscore the need for careful monitoring of opioid use in these survivors and the exploration of alternative pain management strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyae270","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T18:31:51Z","timestamp":1728930711000},"source":"Crossref","is-referenced-by-count":3,"title":["Opioid use and adverse health effects in breast cancer survivors"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8563-3330","authenticated-orcid":false,"given":"Reina","family":"Haque","sequence":"first","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research & Evaluation, , Pasadena, CA 91101 ,","place":["United States"]},{"name":"Kaiser Permanente Bernard J. Tyson School of Medicine Department of Health Systems Science, , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lie Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research & Evaluation, , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxiao","family":"Shi","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research & Evaluation, , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research & Evaluation, , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moira","family":"Brady-Rogers","sequence":"additional","affiliation":[{"name":"Alive & Well Women , South Pasadena, CA 91030 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowan T","family":"Chlebowski","sequence":"additional","affiliation":[{"name":"The Lundquist Research Institute for Biomedical Innovation at UCLA-Harbor & Division of Medical Oncology and Hematology , Torrance, CA 90502 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rulin C","family":"Hechter","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Southern California Department of Research & Evaluation, , Pasadena, CA 91101 ,","place":["United States"]},{"name":"Kaiser Permanente Bernard J. 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