{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:23:58Z","timestamp":1740140638387,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scottsdale Healthcare Hospitals dba. HonorHealth"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN), a common problem, can impair function and quality of life in patients, potentially limiting chemotherapy and adversely affecting outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This trial compared investigational hand therapy intervention (Investigational) compared with a traditional occupational therapy approach (Traditional) to prevent CIPN in patients with pancreatic cancer receiving gemcitabine and albumin-bound paclitaxel containing regimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>forty-nine patients were enrolled with 40 evaluable for statistical analysis (21 Investigational\/19 Traditional). CIPN in the hands was reported in 6 patients (28.6%) in Investigational, and 4 (21.1%) in Traditional P\u2005=\u2005.721. Kaplan-Meier analysis showed a mean time-to-event of 76.0 days (90% CI: 68.5, 83.6), and 75.8 (90% CI: 68.5, 83.2) days respectively, P\u2005=\u2005.614. Fifteen patients in each group (78.9% Traditional, 71.4% in Investigational) were censored as they did not develop CIPN. No correlation was found between CIPN risk and age, sex, BMI, disease stage, performance status, or chemotherapy dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Seventy-four percent of patients receiving gemcitabine, albumin-bound paclitaxel, and cisplatin did not develop CIPN of the hands by day 84. There was no statistical difference in time to onset of CIPN between the two groups. Early adaption of occupational therapy may prevent early onset CIPN in chemotherapy patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>ClinicalTrials.gov Identifier<\/jats:title>\n                  <jats:p>NCT05374876.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyae285","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:22:39Z","timestamp":1729617759000},"page":"1095-e1778","source":"Crossref","is-referenced-by-count":0,"title":["Hand therapy interventions for the prevention of chemotherapy-induced peripheral neuropathy of the hands in patients with pancreatic cancer"],"prefix":"10.1093","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0987-5965","authenticated-orcid":false,"given":"Gayle S","family":"Jameson","sequence":"first","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Cooper","sequence":"additional","affiliation":[{"name":"Cooper Hand Therapy , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"Snyder","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M","family":"Buchanan","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri","family":"Strelish","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Shearon","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D","family":"Von Hoff","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt","family":"Bay","sequence":"additional","affiliation":[{"name":"A. 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Still University , Mesa, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne","family":"Hull","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorilyn A","family":"Kaatz","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkut H","family":"Borazanci","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute , Scottsdale, AZ ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"2024121021070912200_CIT0001","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/B978-0-323-52479-7.00038-7","article-title":"Chemotherapy-induced peripheral neuropathy","volume-title":"Cooper\u2019s Fundamentals of Hand Therapy: Clinical Reasoning and Treatment Guidelines for Common Diagnoses of the Upper Extremity","author":"Cooper","year":"2020","edition":"3"},{"key":"2024121021070912200_CIT0002","doi-asserted-by":"publisher","first-page":"e2239788","DOI":"10.1001\/jamanetworkopen.2022.39788","article-title":"Association of taxane type with patient-reported chemotherapy-induced peripheral neuropathy among patients with breast cancer","volume":"5","author":"Mo","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2024121021070912200_CIT0003","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"key":"2024121021070912200_CIT0004","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ejca.2015.10.017","article-title":"Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: a subset analysis from a randomised phase III trial (MPACT)","volume":"52","author":"Goldstein","year":"2016","journal-title":"Eur J Cancer"},{"key":"2024121021070912200_CIT0005","doi-asserted-by":"publisher","first-page":"e12421","DOI":"10.1111\/ecc.12421","article-title":"Predictors of duloxetine response in patients with oxaliplatin-induced painful chemotherapy-induced peripheral neuropathy (CIPN): a secondary analysis of randomised controlled trial - 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