{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:28:11Z","timestamp":1788827291183,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop a neurotoxicity risk prediction model in a diverse cohort of children with ALL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included children (age 2-20 years) diagnosed with ALL (2005-2019) and treated in Texas without pre-existing neurologic disease. Clinical information was obtained by medical record review. Neurotoxicity occurring post-induction and prior to maintenance therapy was defined as neurologic episodes occurring within 21 days of methotrexate. Suspected cases were independently confirmed by 2 pediatric oncologists. Demographic and clinical factors were compared using logistic regression. The dataset was randomly split (80\/20) for training and testing. random forest (RF) with boosting and downsampling using 5-repeat, 10-fold cross-validation was used to construct a predictive model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Neurotoxicity developed in 115 (8.7%) of 1325 eligible patients. Several factors including older age at diagnosis (OR\u2005=\u20051.19, 95% CI: 1.15-1.24) and Latino ethnicity (OR\u2005=\u20052.79, 95% CI: 1.83-4.35) were associated with neurotoxicity. The RF had an area under the curve of 0.77 with a train error rate of 0.29 and a test error rate of 0.24. The overall sensitivity was 0.73, and specificity was 0.69.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In one of the largest studies of its kind, we developed a novel risk prediction model of methotrexate-related neurotoxicity. Ultimately, a validated model may help guide the development of personalized treatment strategies to reduce the burden of neurotoxicity in children diagnosed with ALL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf055","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T01:07:28Z","timestamp":1751159248000},"source":"Crossref","is-referenced-by-count":4,"title":["Prediction of methotrexate neurotoxicity using clinical, sociodemographic, and area-based information in children with acute lymphoblastic leukemia"],"prefix":"10.1093","volume":"30","author":[{"given":"Rachel D","family":"Harris","sequence":"first","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]},{"name":"Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas Health Science Center at Houston , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A","family":"Taylor","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Monica","family":"Gramatges","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E","family":"Hughes","sequence":"additional","affiliation":[{"name":"Peter O\u2019Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Zobeck","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandi","family":"Pruitt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas Health Science Center at Houston , Houston, TX ,","place":["USA"]},{"name":"Peter O\u2019Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Brooke","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Deparment of Pharmacy and Pharmaceutical Sciences, St. Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Chavana","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Huynh","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Orange County, University of California Irvine College of Medicine , Orange, CA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Klesse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center , Dallas, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Heym","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Cook Children\u2019s Medical Center , Fort Worth, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Griffin","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Erana","sequence":"additional","affiliation":[{"name":"Vannie E. Cook Children\u2019s Clinic, Cancer and Hematology Clinic , McAllen, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Bernini","sequence":"additional","affiliation":[{"name":"Vannie E. Cook Children\u2019s Clinic, Cancer and Hematology Clinic , McAllen, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Choi","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuu","family":"Ohno","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A","family":"Richard","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna C","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas Health Science Center at Houston , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9510-4923","authenticated-orcid":false,"given":"Han","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas Health Science Center at Houston , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas Health Science Center at Houston , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J","family":"Lupo","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R","family":"Rabin","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-5073","authenticated-orcid":false,"given":"Austin L","family":"Brown","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital, Cancer and Hematology Center , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Division of Hematology\/Oncology, Baylor College of Medicine , Houston, TX ,","place":["USA"]},{"name":"Department of Pediatrics, Baylor College of Medicine, Center for Epidemiology and Population Health , Houston, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"2025062821072379300_CIT0001","author":"American Cancer Society [Internet]","year":"2019"},{"key":"2025062821072379300_CIT0002","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1158\/1055-9965.EPI-19-0941","article-title":"Cancer progress and priorities: childhood cancer","volume":"29","author":"Lupo","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025062821072379300_CIT0003","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/cncr.23169","article-title":"Trends in childhood cancer incidence in the U.S. (1992-2004)","volume":"112","author":"Linabery","year":"2008","journal-title":"Cancer"},{"key":"2025062821072379300_CIT0004","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children\u2019s oncology group","volume":"30","author":"Hunger","year":"2012","journal-title":"J Clin Oncol"},{"key":"2025062821072379300_CIT0005","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.1016\/S2352-3026(22)00371-4","article-title":"Racial and ethnic disparities in childhood and young adult acute lymphocytic leukaemia: secondary analyses of eight Children\u2019s Oncology Group cohort trials","volume":"10","author":"Gupta","year":"2023","journal-title":"Lancet Haematol"},{"key":"2025062821072379300_CIT0006","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1200\/JCO.2015.62.4544","article-title":"Dexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia: a report from children\u2019s oncology group study AALL0232","volume":"34","author":"Larsen","year":"2016","journal-title":"J Clin Oncol: Off J Am Soc Clin Oncol"},{"key":"2025062821072379300_CIT0007","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1200\/JCO.2013.53.0808","article-title":"Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia","volume":"32","author":"Bhojwani","year":"2014","journal-title":"J Clin Oncol: Off J Am Soc Clin Oncol"},{"key":"2025062821072379300_CIT0008","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.1158\/1078-0432.CCR-18-0939","article-title":"Disparities in neurotoxicity risk and outcomes among pediatric acute lymphoblastic leukemia patients","volume":"24","author":"Taylor","year":"2018","journal-title":"Clin Cancer Res: Off J Am Assoc Cancer Res"},{"key":"2025062821072379300_CIT0009","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3324\/haematol.2020.268565","article-title":"Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia","volume":"107","author":"Mateos","year":"2021","journal-title":"Haematologica"},{"key":"2025062821072379300_CIT0010","doi-asserted-by":"publisher","first-page":"e231","DOI":"10.1016\/S1470-2045(16)30035-3","article-title":"Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus","volume":"17","author":"Schmiegelow","year":"2016","journal-title":"Lancet Oncol"},{"key":"2025062821072379300_CIT0011","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1200\/JCO.1998.16.5.1712","article-title":"Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study","volume":"16","author":"Mahoney","year":"1998","journal-title":"J Clin Oncol"},{"key":"2025062821072379300_CIT0012","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/cncr.34646","article-title":"Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate","volume":"129","author":"Harris","year":"2023","journal-title":"Cancer"},{"key":"2025062821072379300_CIT0013","doi-asserted-by":"publisher","first-page":"9273","DOI":"10.3390\/ijerph18179273","article-title":"Residence in a hispanic enclave is associated with inferior overall survival among children with acute lymphoblastic leukemia","volume":"18","author":"Schraw","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"2025062821072379300_CIT0014","doi-asserted-by":"publisher","first-page":"e28525","DOI":"10.1002\/pbc.28525","article-title":"Area deprivation is associated with poorer overall survival in children with acute lymphoblastic leukemia","volume":"67","author":"Schraw","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"2025062821072379300_CIT0015","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1080\/02664763.2017.1414166","article-title":"Predicting risk for adverse health events using random forest","volume":"45","author":"Cafri","year":"2018","journal-title":"J Appl Stat"},{"key":"2025062821072379300_CIT0016","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1080\/10428194.2021.1913140","article-title":"Machine learning to predict high-dose methotrexate-related neutropenia and fever in children with B-cell acute lymphoblastic leukemia","volume":"62","author":"Zhan","year":"2021","journal-title":"Leuk Lymphoma"},{"key":"2025062821072379300_CIT0017","doi-asserted-by":"publisher","first-page":"103631","DOI":"10.1016\/j.ebiom.2021.103631","article-title":"Accurate diagnosis and prognosis prediction of gastric cancer using deep learning on digital pathological images: a retrospective multicentre study","volume":"73","author":"Huang","year":"2021","journal-title":"EBioMedicine"},{"key":"2025062821072379300_CIT0018","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41598-023-28394-6","article-title":"Iterated cross validation method for prediction of survival in diffuse large B-cell lymphoma for small size dataset","volume":"13","author":"Chang","year":"2023","journal-title":"Sci Rep"},{"key":"2025062821072379300_CIT0019","doi-asserted-by":"crossref","first-page":"e80547","DOI":"10.7554\/eLife.80547","article-title":"Early stage NSCLS patients\u2019 prognostic prediction with multi-information using transformer and graph neural network model","volume":"11","author":"Lian","year":"2022","journal-title":"Elife"},{"key":"2025062821072379300_CIT0020","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.suronc.2020.11.002","article-title":"Deep learning enabled prediction of 5-year survival in pediatric genitourinary rhabdomyosarcoma","volume":"36","author":"Bhambhvani","year":"2021","journal-title":"Surg Oncol"},{"key":"2025062821072379300_CIT0021","doi-asserted-by":"crossref","first-page":"1003347","DOI":"10.3389\/fimmu.2022.1003347","article-title":"A deep belief network-based clinical decision system for patients with osteosarcoma","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"2025062821072379300_CIT0022","doi-asserted-by":"publisher","first-page":"e200265","DOI":"10.1001\/jamanetworkopen.2020.0265","article-title":"Evaluation of combined artificial intelligence and radiologist assessment to interpret screening mammograms","volume":"3","author":"Schaffter","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2025062821072379300_CIT0023","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S2468-1253(24)00161-4","article-title":"Polyp detection with colonoscopy assisted by the GI Genius artificial intelligence endoscopy module compared with standard colonoscopy in routine colonoscopy practice (COLO-DETECT): a multicentre, open-label, parallel-arm, pragmatic randomised controlled trial","volume":"9","author":"Seager","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025062821072379300_CIT0024","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jdin.2023.08.019","article-title":"Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: a comparative effectiveness study","volume":"14","author":"Manolakos","year":"2023","journal-title":"JAAD Int"},{"key":"2025062821072379300_CIT0025","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41746-020-00324-0","article-title":"The state of artificial intelligence-based FDA-approved medical devices and algorithms: an online database","volume":"3","author":"Benjamens","year":"2020","journal-title":"NPJ Digit Med"},{"key":"2025062821072379300_CIT0026","year":"2017"},{"key":"2025062821072379300_CIT0027","year":"2010"},{"key":"2025062821072379300_CIT0028","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1023\/a:1011240019516","article-title":"Socioeconomic status and breast cancer incidence in California for different race\/ethnic groups","volume":"12","author":"Yost","year":"2001","journal-title":"Cancer Causes Control"},{"key":"2025062821072379300_CIT0029","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1002\/cncr.29345","article-title":"The impact of neighborhood social and built environment factors across the cancer continuum: Current research, methodological considerations, and future directions","volume":"121","author":"Gomez","year":"2015","journal-title":"Cancer"},{"key":"2025062821072379300_CIT0030","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random Forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach Learn"},{"key":"2025062821072379300_CIT0031","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1002\/(sici)1097-0258(19970228)16:4&lt;385::aid-sim380&gt;3.0.co;2-3","article-title":"The lasso method for variable selection in the cox model","volume":"16","author":"Tibshirani","year":"1997","journal-title":"Stat Med"},{"key":"2025062821072379300_CIT0032","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1182\/hematology.2021000269","article-title":"Managing therapy-associated neurotoxicity in children with ALL","volume":"2021","author":"Bhojwani","year":"2021","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"2025062821072379300_CIT0033","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/pbc.25850","article-title":"Rechallenging With Intrathecal Methotrexate After Developing Subacute Neurotoxicity in Children With Hematologic Malignancies","volume":"63","author":"Badke","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"2025062821072379300_CIT0034","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/jnci\/84.4.252","article-title":"Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia","volume":"84","author":"Winick","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"2025062821072379300_CIT0035","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/MPH.0000000000000696","article-title":"Using a bedside algorithm to individually dose high-dose methotrexate for patients at risk for toxicity","volume":"39","author":"Foster","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025062821072379300_CIT0036","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00280-018-3733-2","article-title":"A prospective study of a simple algorithm to individually dose high-dose methotrexate for children with leukemia at risk for methotrexate toxicities","volume":"83","author":"Foster","year":"2019","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["The Oncologist"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/30\/6\/oyaf055\/63551603\/oyaf055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/oncolo\/article-pdf\/30\/6\/oyaf055\/63551603\/oyaf055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T01:07:29Z","timestamp":1751159249000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/oncolo\/article\/doi\/10.1093\/oncolo\/oyaf055\/8171901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,4]]}},"URL":"https:\/\/doi.org\/10.1093\/oncolo\/oyaf055","relation":{},"ISSN":["1083-7159","1549-490X"],"issn-type":[{"value":"1083-7159","type":"print"},{"value":"1549-490X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,6]]},"article-number":"oyaf055"}}