{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:43:40Z","timestamp":1793785420233,"version":"4.6.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This population-based retrospective cohort study included patients with AM and a confirmed history of trauma who received treatment at 5 melanoma treatment centers in China. Factors associated with recurrence and survival were analyzed using univariate and multivariate Cox regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Totally 468 AM cases were included in this study, with 101 patients in the trauma group and 367 in the non-trauma group. The trauma group had more patients with ulceration (P\u2005=\u2005.027), mitotic rate\u2005\u2265\u20051 (P\u2005=\u2005.036), and Clark level IV-V (P\u2005=\u2005.009) than the non-trauma group. Among stage I-II postoperative AM patients, the median recurrence-free survival (RFS) was 33.3 months (95% CI: 18.8-47.8) and 115.6 months (95% CI: 96.3-135.0) in the trauma and non-trauma groups, respectively (P\u2005&amp;lt;\u2005.001). Similarly, the median overall survival (OS) was 64.6 (95% CI: 54.8-74.4) and not reached (95% CI: NR), respectively (P\u2005=\u2005.002). Comparatively, no significant differences were observed in RFS or OS between the trauma and non-trauma groups in patients with stage III and IV AM. Multifactorial analysis showed that trauma was an independent risk factor for RFS and OS only in patients with stage I-II AM patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Postoperative stage I-II patients in the trauma group had significantly worse RFS and OS compared to those in the non-trauma group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf086","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T06:09:02Z","timestamp":1746943742000},"source":"Crossref","is-referenced-by-count":3,"title":["Poor prognosis of early-stage acral melanoma with a history of trauma: a multicenter analysis of 468 patients"],"prefix":"10.1093","volume":"30","author":[{"given":"Yi","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Oncology, Cancer Center, The First Hospital of Jilin University , Changchun,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Genitourinary Medicine, Harbin Medical University Cancer Hospital , Harbin,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Third People\u2019s Hospital of Zhengzhou , Zhengzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Genitourinary Medicine, Harbin Medical University Cancer Hospital , Harbin,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Center, The First Hospital of Jilin University , Changchun,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Third People\u2019s Hospital of Zhengzhou , Zhengzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Center, The First Hospital of Jilin University , Changchun,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxue","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harbin Medical University Cancer Hospital , Harbin,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Dalian Medical University , Dalian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Third People\u2019s Hospital of Zhengzhou , Zhengzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Center, The First Hospital of Jilin University , Changchun,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-798X","authenticated-orcid":false,"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cancer Center, The First Hospital of Jilin University , 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