{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:04:39Z","timestamp":1784664279148,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation of China","award":["2022J011061"],"award-info":[{"award-number":["2022J011061"]}]},{"name":"Subsidy Funds for Medical Double-high Project of Fujian Province","award":["ETK2024007"],"award-info":[{"award-number":["ETK2024007"]}]},{"name":"Subsidy Funds for Medical Double-high Project of Fujian Province","award":["ETK2022002"],"award-info":[{"award-number":["ETK2022002"]}]},{"name":"Fujian Children\u2019s Hospital Cultivation Project","award":["YP202401"],"award-info":[{"award-number":["YP202401"]}]},{"name":"Joint Funds for the Innovation of Science and Technology","award":["2024Y9554"],"award-info":[{"award-number":["2024Y9554"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The differences in the epidemiology, clinical characteristics, and treatment strategies between primary lymphoma of the female reproductive tract (PLFGT) and primary lymphoma of the male reproductive tract (PLMGT) remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>A retrospective analysis of PLFGT and PLMGT data from the surveillance, epidemiology, and end results database spanning 2000 to 2021 was conducted to compare the differences in incidence rates and clinical indicators. Bar chart analysis highlighted the distribution differences between lymphoma subgroups. Multivariate Cox regression models were used to identify prognostic factors. Kaplan\u2013Meier analysis was performed to evaluate prognostic survival outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Data from 724 patients with PLFGT and 2025 with PLMGT were analyzed, with diffuse large B-cell lymphoma (DLBCL) being the most prevalent subtype. The incidence of PLFGT was higher than that of PLMGT; however, the incidence rates in both groups decreased. Among DLBCL cases, the testis was the most frequent primary site in men, whereas the ovary predominated in women with follicular lymphoma. The prognostic risk factors for PLFGT included age, pathological type, primary site, surgery, and chemotherapy, whereas those for PLMGT include age, pathological type, chemotherapy, and radiation. In the DLBCL subtype of PLFGT in the study, combined chemotherapy and radiation reportedly enhance cancer-specific survival in patients in a limited stage (Ann Arbor stage I and II). In contrast, for patients with an advanced stage (Ann Arbor stage III and IV), combined chemotherapy and surgery yielded the most favorable survival outcomes. In the DLBCL subtype of PLMGT, combined chemotherapy, radiation, and surgery demonstrated the most effective therapeutic outcomes across both the limited and advanced stages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Clinical differences were observed between PLFGT and PLMGT. Prompt and accurate identification of risk factors and implementing integrated treatment strategies are essential for optimizing patient outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf102","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:24:31Z","timestamp":1747229071000},"source":"Crossref","is-referenced-by-count":1,"title":["Sex-specific differences in reproductive tract lymphomas: epidemiology, clinical features, and treatment outcomes"],"prefix":"10.1093","volume":"30","author":[{"given":"Shan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology\u2013Oncology, Fujian Children\u2019s Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University , Fuzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital , Fuzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-0530","authenticated-orcid":false,"given":"Yaobin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors (Fujian Medical University), Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies) , Fuzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"2025052712005545400_CIT0001","doi-asserted-by":"publisher","first-page":"1234861","DOI":"10.3389\/fmed.2023.1234861","article-title":"Primary diffuse large B-cell tumor of the uterus: a case report","volume":"10","author":"Zhang","year":"2023","journal-title":"Front Med"},{"key":"2025052712005545400_CIT0002","doi-asserted-by":"publisher","first-page":"1438812","DOI":"10.3389\/fonc.2024.1438812","article-title":"Malignant primary female genital system lymphoid","volume":"14","author":"Jia","year":"2024","journal-title":"Front Oncol"},{"key":"2025052712005545400_CIT0003","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1080\/07853890.2022.2046289","article-title":"Epidemiological features for primary lymphoma of the female genital tract patients and development of a nomogram to predict survival","volume":"54","author":"Peng","year":"2022","journal-title":"Ann Med"},{"key":"2025052712005545400_CIT0004","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12905-024-03037-8","article-title":"Primary lymphoma of the female genital tract masquerading as gynecological malignancy","volume":"24","author":"Shi","year":"2024","journal-title":"BMC Womens Health"},{"key":"2025052712005545400_CIT0005","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00277-024-05668-1","article-title":"Epidemiological features and a survival nomogram for primary lymphoma of the male genital tract","volume":"103","author":"Xie","year":"2024","journal-title":"Ann Hematol"},{"key":"2025052712005545400_CIT0006","doi-asserted-by":"publisher","first-page":"10269","DOI":"10.1007\/s00432-023-04907-8","article-title":"What factors are associated with the prognosis of primary testicular diffuse large B-cell lymphoma? 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