{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:10:10Z","timestamp":1787062210120,"version":"build-2736575974"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EU NAVIGATE"},{"name":"International Pragmatic Randomized Controlled Trial"},{"name":"NavCare-EU Intervention for Older People"},{"name":"Cancer and Their Family Caregivers"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["101057361"],"award-info":[{"award-number":["101057361"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020655","name":"European Health and Digital Executive Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020655","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation Flanders\u2014Fonds Wetenschappelijk Onderzoek","award":["12AEO24N"],"award-info":[{"award-number":["12AEO24N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older adults with cancer often experience frailty and comorbidities, potentially impacting their quality of life. Knowledge on quality-of-life changes throughout the cancer trajectory is important to set feasible expectations in interventions or trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review synthesizes existing knowledge on quality-of-life changes in older adults with cancer throughout their illness trajectory and explores potential individual, relational, community, and societal factors associated with these changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, and PsycINFO. We synthesized characteristics and outcomes of all studies reporting on quality-of-life or well-being changes in people aged 65+ with cancer. We used Bronfenbrenner\u2019s Social Ecological Model to categorize associated factors. We followed PRISMA guidelines and registered in PROSPERO (CRD42024566815).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 22 studies. Studies varied in characteristics of the cohorts and timing of the measurements and were often lacking clear quality-of-life conceptualizations. All studies used a quantitative design, except 1 mixed-methods study. Eight of 9 studies with follow-up moments of 12\u2009months or more reported stable quality-of-life scores. All 3 studies examining the last year of life found quality-of-life declines. Five other studies reported a decline during treatment; in 4 studies followed by an increase. Comorbidities, older age, and mobility problems were most frequently associated with declining quality of life. Relational, community, and societal level factors were rarely studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the methodological heterogeneity between studies, we identified trends in quality-of-life changes across the illness trajectories of older adults with cancer, particularly declining trends during treatment and end-of-life periods and stable trends in long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf223","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T10:08:48Z","timestamp":1752746928000},"source":"Crossref","is-referenced-by-count":4,"title":["Changes in quality of life throughout the illness trajectory of older adults with cancer: a systematic 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