{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:16:23Z","timestamp":1790082983234,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["2022ZB058"],"award-info":[{"award-number":["2022ZB058"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent dose-limiting toxicity in breast cancer patients. Electroacupuncture (EA) shows promise but optimal stimulation parameters remain undefined. We conducted a randomized trial comparing EA frequencies for CIPN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-center, single-blind trial randomized patients to 2, 100, and 2\/100\u2009Hz EA, or mecobalamin (Mecbl). The primary outcome was the patient neurotoxicity questionnaire (PNQ) response rate at Week 4. Secondary outcomes included PNQ scores, National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) grades at Weeks 4\/8, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire\u2014Chemotherapy-Induced Peripheral Neuropathy 20 (EORTC QLQ-CIPN20) and Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) scales.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>2\/100\u2009Hz EA achieved the highest overall response rate. Both 2 and 2\/100\u2009Hz EA improved PNQ sensory scores at Week 4. Sensory scores improved across groups, while motor scores decreased with 2 and 2\/100\u2009Hz EA. Only 2\u2009Hz EA improved autonomic function. For quality-of-life, 2\u2009Hz EA enhanced physical function, fatigue, pain and insomnia, while 2\/100\u2009Hz EA improved nausea\/vomiting, constipation, appetite and global health with additional pain relief at Week 4. The 100\u2009Hz EA group showed no significant benefits in these domains.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study preliminarily explored EA\u2019s potential benefits for CIPN, with 2\/100\u2009Hz showing the highest response rate and 2\u2009Hz demonstrating sensory improvement advantages. Different frequencies produced distinct therapeutic profiles. Further research should evaluate frequency-specific effects of EA for CIPN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf262","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T17:47:45Z","timestamp":1755625665000},"source":"Crossref","is-referenced-by-count":11,"title":["Electroacupuncture frequency for chemotherapy-induced neuropathy in breast cancer: a randomized controlled trial"],"prefix":"10.1093","volume":"30","author":[{"given":"Qiongying","family":"Shen","sequence":"first","affiliation":[{"name":"The Third Clinical Medical College, Zhejiang Chinese Medical University , Hangzhou 310053,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehou","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital , Hangzhou 310022,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, Zhejiang Cancer Hospital , Hangzhou 310022,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Ruan","sequence":"additional","affiliation":[{"name":"School of Nursing, The Hong Kong Polytechnic University , Hong Kong Special Administrative Region 999077,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Breast Medical Oncology, Zhejiang Cancer Hospital , Hangzhou 310022,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital , Hangzhou 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Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang, Chinese Medical University (Zhongshan Hospital of Zhejiang Province) , Hangzhou 310009,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-5797","authenticated-orcid":false,"given":"Chao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Zhejiang Cancer Hospital , Hangzhou 310022,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"2025092002375781500_oyaf262-B1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J 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