{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:35:04Z","timestamp":1787596504315,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Province Clinical Key Specialty Construction"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The optimal treatment strategy for limited-stage small cell esophageal carcinoma (LS-SCEC) remains uncertain. This study aimed to retrospectively evaluate the efficacy of perioperative therapy in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Between June 2005 and November 2022, 156 patients with LS-SCEC who underwent esophagectomy were included in this study. The primary endpoint was overall survival (OS), and secondary endpoints included disease-free survival (DFS) and postoperative complications. Prognostic factors were analyzed using univariate and multivariate Cox regression models, as well as propensity score matching.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 156 patients, 33 (21.2%) patients received neoadjuvant chemotherapy, 76 (48.7%) underwent adjuvant chemotherapy, and 13 (8.3%) received adjuvant chemoradiotherapy. Post-surgery, 33 (21.2%) patients were classified as stage I, 40 (25.6%) as stage II, 61 (39.1%) as stage III, and 22 (14.1%) as stage IV. The median OS was 21.0\u2009months, with 5-year OS and DFS rates of 25.9% and 21.9%, respectively. Multivariate analysis identified clinical T stage (P\u2009=\u2009.049), neural invasion (P\u2009=\u2009.002), N stage (P\u2009=\u2009.006), and adjuvant therapy (P\u2009=\u2009.001) as independent prognostic factors. Neoadjuvant chemotherapy significantly improved OS, with a 5-year OS rate of 37.7% compared to 0.0% in the non-neoadjuvant chemotherapy group (P\u2009&amp;lt;\u2009.001). Across the cohort, adjuvant therapy enhanced both OS and DFS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Perioperative therapy is crucial for LS-SCEC management. Neoadjuvant chemotherapy improves OS in patients with LS-SCEC. Adjuvant chemotherapy is recommended almost for all patients with LS-SCEC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf264","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T11:29:58Z","timestamp":1756034998000},"source":"Crossref","is-referenced-by-count":1,"title":["Perioperative therapy for limited-stage small cell esophageal carcinoma: a retrospective cohort study"],"prefix":"10.1093","volume":"30","author":[{"given":"Jun","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Tao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Feng","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Zhao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8834-6801","authenticated-orcid":false,"given":"Xiang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China , Chengdu 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