{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:30:10Z","timestamp":1766719810428,"version":"build-2065373602"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University Hospital of Antwerp","award":["19\/04\/2020-30\/06\/2023"],"award-info":[{"award-number":["19\/04\/2020-30\/06\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic impact of primary tumor location (right- vs left-sided) is well-established in stage III\/IV colorectal cancer (CRC), with right-sided tumors associated with poorer outcomes. However, its prognostic role in stage II CRC remains unclear. This study investigates whether the worse outcomes observed in advanced right-sided cancers also apply to early-stage CRC, or if they may be influenced by other factors such as patient demographics and molecular biomarkers. Clarifying this could help improve risk stratification in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>For this study, we analyzed data of all Belgian patients diagnosed with stage II CRC in 2015-2016 (n\u2009=\u20093.278, data obtained from the Belgian Cancer Registry). Information on primary tumor location, demographics, pathologic T-category, molecular biomarkers (including microsatellite instability [MSI], BRAF, and KRAS status), and overall survival (OS) was collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the univariable analysis, patients with stage II right-sided colon cancer had a significantly worse OS than left-sided colon cancer. Furthermore, advanced age and pT4 were also associated with worse OS. However, in the multivariable analysis, only gender, age, and pathologic T-category significantly affected OS. Primary tumor location was not significantly associated with OS in the multivariable analysis. Furthermore, the molecular biomarkers did not show a significant effect in either analysis. However, due to the limited size of the multivariable cohort, these results should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The primary tumor location is not an independent prognostic factor in stage II CRC with a confounding effect of age. Notably, \u00admolecular biomarkers did not affect the prognosis in either uni- or multivariable analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf317","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T11:45:26Z","timestamp":1759578326000},"source":"Crossref","is-referenced-by-count":1,"title":["Prognosis in stage II colorectal cancer: the effect of the primary tumor location and biomarkers\u2014a retrospective cohort study"],"prefix":"10.1093","volume":"30","author":[{"given":"Jules","family":"Colebunders","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp , Wilrijk, 2610,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brecht","family":"Mullebrouck","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp , Wilrijk, 2610,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Li\u00e9geois","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp , Wilrijk, 2610,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Peeters","sequence":"additional","affiliation":[{"name":"Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital , Edegem, 2650,","place":["Belgium"]},{"name":"Integrated Personalized and Precision Oncology Network (IPPON), Center for Oncological Research (CORE), University of Antwerp , Wilrijk, 2610,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greetje","family":"Vanhoutte","sequence":"additional","affiliation":[{"name":"Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital , Edegem, 2650,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Van Damme","sequence":"additional","affiliation":[{"name":"Belgian Cancer Registry , Brussels, 1210,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-4592","authenticated-orcid":false,"given":"Katleen","family":"Janssens","sequence":"additional","affiliation":[{"name":"Center of Medical Genetics, University of Antwerp and Antwerp University Hospital , Edegem, 2650,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5305","authenticated-orcid":false,"given":"Timon","family":"Vandamme","sequence":"additional","affiliation":[{"name":"Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital , Edegem, 2650,","place":["Belgium"]},{"name":"Integrated Personalized and Precision Oncology Network (IPPON), Center for 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