{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:26:57Z","timestamp":1787660817117,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The rising incidence of early-onset gastrointestinal (GI) cancer has made the impact of treatments on fertility of high significance. While there is abundant evidence on oncofertility outcomes in breast cancer and hematological malignancies, data regarding these perspectives in GI cancers is lacking. We sought to evaluate current practices of fertility preservation (FP) among GI oncologists across Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional survey was distributed through the Gastrointestinal Tract Cancer Group (GITCG) of the EORTC network and affiliated cooperative groups and cancer centers using a 10-item electronic survey regarding oncofertility practices. The target population was oncologists who routinely treat GI cancers. A statistical analysis was performed based on country, patient volume, and tumor type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and twenty-six GI oncologists from 27 countries completed the survey, the majority from high volume cancer centers. Fifty seven percent of the participating oncologists routinely discuss the impact of treatment on fertility in any patient &amp;lt;40\u2009years, while 36% discuss this only in the curative setting. Fifty-nine percent refer female patients to standard FP options (embryo\/oocyte preservation), while 24% chose to refer to ovarian cryopreservation. Of note, 17% indicated they would not refer a curative patient for FP at all due to time or resource issues. Sixty five percent routinely refer male patients to sperm preservation. Use of Gonadotropin Releasing Hormone analogues (GnRHa) in CRC patients is recommended by 34% of oncologists. In the setting of pelvic radiation, 65% refer a female patient for ovarian transposition before pelvic irradiation; 32% would consider uterine transposition. Sixty one percent would consider a nonradiation protocol as perioperative chemotherapy as a valid option for young female patients. We observed heterogeneity upon country but not upon physician gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study indicates a substantial diversity in current practices in Europe with regard to FP in young cancer patients with GI malignancies, which is not always aligned with current guidelines. There is a need to disseminate and educate GI oncologists on oncofertility perspectives and contemporary data. Additionally, there is a need to establish evidence on the utility of fertility preservation options for patients with GI cancers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf350","type":"journal-article","created":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:59:24Z","timestamp":1762649964000},"source":"Crossref","is-referenced-by-count":2,"title":["Fertility preservation practices and gastrointestinal oncologist in Europe: a pan-European study"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-5477","authenticated-orcid":false,"given":"Irit","family":"Ben-Aharon","sequence":"first","affiliation":[{"name":"Division of Oncology, Rambam Health Care Campus , Haifa 31096,","place":["Israel"]},{"name":"Rappaport Faculty of Medicine, Technion \u2013 Israel Institute of Technology , Haifa 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31008,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Arnold","sequence":"additional","affiliation":[{"name":"Asklepios Tumor Center Hamburg and AK Altona , Hamburg 22763,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"van Laarhoven","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center , Amsterdam 1081 HV,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneli","family":"Elme","sequence":"additional","affiliation":[{"name":"Chemotherapy Center, North Estonia Medical Center Foundation , Tallinn 13419,","place":["Estonia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"Buffart","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Center , Amsterdam 1081 HV,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Fokter-Dovnik","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Medical Centre Maribor , Maribor 2000,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Sokop","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University , Brno 625 00,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Obermanova","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University , Brno 625 00,","place":["Czech 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1070,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-0246","authenticated-orcid":false,"given":"Elena","family":"Elez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron University Hospital and Institute of Oncology (VHIO), Universitat Aut\u00f2noma de Barcelona , Barcelona 08035,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4753","authenticated-orcid":false,"given":"Julien","family":"Taieb","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris 75006,","place":["France"]},{"name":"Assistance Publique\u2013H\u00f4pitaux de Paris, Department of Digestive Oncology, H\u00f4pital Europ\u00e9en Georges Pompidou, SIRIC CARPEM , Paris 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