{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T08:16:16Z","timestamp":1765440976757,"version":"3.46.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metastatic colorectal cancer (mCRC) remains a leading cause of cancer-related mortality. While metastasectomy could improve survival in selected patients, the role of repeated resections in oligorecurrent disease is less defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients with mCRC treated at Fondazione Policlinico Universitario Agostino Gemelli-IRCCS (Rome, Italy) between 2010 and 2024. Eligible patients underwent \u22652 resections of metastatic lesions. Disease-free survival after second metastasectomy (DFS2) and overall survival (OS) were the coprimary end points. Prognostic factors were tested with Cox regression, and a composite risk score (Fondazione Policlinico Gemelli Risk Score [FPGRiskScore]) was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1586 patients with mCRC, 396 (24.9%) received at least one metastatic surgery and 143 (9%) underwent \u22652 metastasectomies. Median DFS2 was 8.2\u2009months (95% confidence interval [CI]: 7.3-13.1), and 5-years OS rate was 73.1% (95% CI: 64.5-83.0); after a median follow-up from the last metastasectomy of 34.3\u2009months, 49\/143 patients (34.2%) were relapse-free and median DFS after the second surgery of the metastases from the last surgery was 13.1\u2009months (95% CI: 9.1-17.5). Patients stratified by FPGRiskScore (disease-free interval [DFI] from the first metastasectomy \u2264 vs. &amp;gt;12\u2009months, metastatic burden \u2264 vs &amp;gt;5\u2009cm, RAS\/BRAF status, and Eastern Cooperative Oncology Group Performance Status [ECOG PS] scale 0 vs. \u22651) showed distinct outcomes: low-risk patients achieved a median DFS2 of 18.4\u2009months and 5-years OS of 87.6%, compared with 7.8\u2009months\/72.0% in intermediate-risk and 4.9\u2009months\/55.3% in high-risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeated metastasectomy offers substantial survival benefit in selected patients with oligorecurrent mCRC, with long-term disease control achievable in a subset. Prognostic stratification incorporating clinical and molecular features (FPGRiskScore) may refine patient selection and guide multidisciplinary management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyaf384","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T12:53:16Z","timestamp":1763211196000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-term survival and prognostic factors after repeated metastasectomies in metastatic colorectal cancer: a 15-years retrospective study"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9526-0725","authenticated-orcid":false,"given":"Giovanni","family":"Trovato","sequence":"first","affiliation":[{"name":"Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario \u201cA Gemelli\u201d\u2014IRCCS , Rome 00168,","place":["Italy"]},{"name":"Medical Department, Catholic University of the Sacred Heart , Rome, 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