{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:48:58Z","timestamp":1789145338276,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"EORTC Quality of Life Group","award":["009\/2016"],"award-info":[{"award-number":["009\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite improvements in survival outcomes for acute myeloid leukemia (AML), limited evidence is available on health-related quality of life (HRQoL) and health problems experienced by long-term survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This international, cross-sectional study evaluated HRQoL, comorbidities, and lifestyle behaviors among long-term AML survivors enrolled from 24 centers across 6 countries. Health-related quality of life was assessed using the SF-36 and the EORTC QLQ-C30 questionnaires, while comorbidities were measured with an adapted version of the validated self-administered comorbidity questionnaire. Lifestyle factors, including physical activity, diet, smoking, alcohol consumption, and body mass index, were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 225 AML survivors were enrolled, with a median time since diagnosis of 8.8\u2009years (IQR 6.4-11.9) and a median age of 58.9\u2009years (IQR 49.0-67.0). Compared with the general population, AML survivors exhibited clinically relevant impairments in SF-36 physical functioning (\u0394\u2009=\u2009\u22128.09, P\u2009&amp;lt;\u2009.001) and role physical scales (\u0394\u2009=\u2009-11.09, P\u2009&amp;lt;\u2009.001), as well as clinically relevant lower physical component summary scores (\u0394\u2009=\u2009-3.94, P\u2009&amp;lt;\u2009.001). Survivors treated with alloSCT reported worse HRQoL profiles compared with those treated with autoSCT or chemotherapy only. Comorbidities were highly prevalent (88.5%), with impaired vision, back pain, and arthrosis\/arthritis being the most frequent. Analysis of lifestyle behaviors showed that 66.2% of AML survivors were physically inactive, 80.2% did not meet dietary recommendations, and 55.3% were overweight\/obese. Multivariate analysis identified physical inactivity as the only independent factor associated with worse HRQoL (\u03b2\u2009=\u2009\u22126.3, P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study shows that AML survivors experience physical limitations and a high comorbidity burden even many years after diagnosis, and it provides insights to better inform survivorship care programs. Further research examining the relationship between physical activity and HRQoL in long-term AML survivors is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag027","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:21:08Z","timestamp":1770034868000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-term health-related quality of life and lifestyle behavior of patients with acute myeloid leukemia"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5166","authenticated-orcid":false,"given":"Fabio","family":"Efficace","sequence":"first","affiliation":[{"name":"Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) , Rome 00182,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cannella","sequence":"additional","affiliation":[{"name":"Data Center and Health Outcomes Research 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00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Capria","sequence":"additional","affiliation":[{"name":"Haematology, Department of Translational and Precision Medicine, Sapienza University of Rome , Rome 00161,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sparano","sequence":"additional","affiliation":[{"name":"Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) , Rome 00182,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Baldi","sequence":"additional","affiliation":[{"name":"Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) , Rome 00182,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesta","family":"Audisio","sequence":"additional","affiliation":[{"name":"SC Ematologia 2, AOU 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Ematologia e Trapianto di Cellule Staminali Emopoietiche, Policlinico Foggia Ospedaliero-Universitario , Foggia 71122,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matevz","family":"Skerget","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Medical Centre Ljubljana , Ljubljana 1000,","place":["Slovenia"]},{"name":"Medical Faculty, University of Ljubljana , Ljubljana 1000,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vignetti","sequence":"additional","affiliation":[{"name":"Data Center and Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) , Rome 00182,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Baron","sequence":"additional","affiliation":[{"name":"CHU Sart Tilman, Division of Hematology, University of Li\u00e8ge , Li\u00e8ge 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