{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:12:04Z","timestamp":1773803524652,"version":"3.50.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSTC 113-2221-E-011-023"],"award-info":[{"award-number":["NSTC 113-2221-E-011-023"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 111-2320-B-532-001-MY3"],"award-info":[{"award-number":["MOST 111-2320-B-532-001-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["NSTC 114-2637-E-011-007"],"award-info":[{"award-number":["NSTC 114-2637-E-011-007"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Breast cancer (BC) treatment, while essential, often impairs quality of life (QoL), typically assessed through \u00adsubjective reports. This single\u2011center, proof\u2011of\u2011concept observational study aimed to develop an objective and noninvasive monitoring method based on spectral analysis of the arterial blood pulse waveform (BPW). We investigated whether specific harmonic indices derived from the BPW could track physiological changes in BC patients following chemotherapy and correlate with patient-reported QoL improvements.<\/jats:p>\n                  <jats:p>Methods: Radial BPW signals were measured noninvasively in 41 BC patients before and after treatment, deriving harmonic indices including amplitude proportion and phase angle. QoL was assessed using the EORTC QLQ-C30 questionnaire. The pulse-distribution analysis (PDA) scoring model was used to classify patients based on their degree of improvement in Global-Health-Status scores.<\/jats:p>\n                  <jats:p>Results: Results showed significant post-chemotherapy decreases in specific harmonic indices, suggesting normalized vascular dynamics. The PDA scoring model effectively classified patients by their Global-Health-Status improvement, achieving an AUC of 0.87 for extreme groups. PDA effect scores demonstrated a significant positive correlation with QoL changes (R\u2009=\u20090.332), outperforming heart rate and its variability. Notably, subgroup analysis revealed this correlation was substantially stronger in early-stage patients (Stage I: R\u2009=\u20090.787). Crucially, PDA scores were not confounded by age.<\/jats:p>\n                  <jats:p>Conclusion: This exploratory study suggests that the pulse\u2011wave\u2011based approach may serve as a low-cost, portable tool for monitoring early physiological changes in BC patients, potentially complementing traditional subjective QoL assessments in clinical practice. The enhanced sensitivity observed in early\u2011stage disease warrants further investigation. These proof\u2011of\u2011concept findings are hypothesis\u2011generating and require validation in larger prospective studies.<\/jats:p>","DOI":"10.1093\/oncolo\/oyag051","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T12:34:28Z","timestamp":1771158868000},"source":"Crossref","is-referenced-by-count":0,"title":["Pulse wave analysis for quality-of-life associated early physiological changes during breast cancer chemotherapy: a proof-of-concept pilot study"],"prefix":"10.1093","volume":"31","author":[{"given":"Chao-Tsung","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Traditional Medicine, College of Medicine, National Yang-Ming Chiao-Tung University , Taipei 112304,","place":["Taiwan"]},{"name":"Department of Traditional Chinese Medicine, Taipei City Hospital RenAi Branch , Taipei 106,","place":["Taiwan"]},{"name":"Department of Recreation and Sport Management, University of Taipei , Taipei 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Medicine, College of Medicine, National Yang-Ming Chiao-Tung University , Taipei 112304,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Feng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Taipei City Hospital, Renai Branch , Taipei 106,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hsuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Taipei City Hospital, Renai Branch , Taipei 106,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Hua","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Traditional Medicine, College of Medicine, National Yang-Ming Chiao-Tung University , Taipei 112304,","place":["Taiwan"]},{"name":"School of Chinese Medicine, College of Medicine, National Yang-Ming Chiao-Tung University , Taipei 112304,","place":["Taiwan"]},{"name":"Department of Traditional Chinese Medicine, National Yang-Ming Chiao-Tung University Hospital , Yilan 260,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3774","authenticated-orcid":false,"given":"Hsin","family":"Hsiu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology , Taipei 106,","place":["Taiwan"]},{"name":"Biomedical Engineering Research Center, National Defense Medical Center , Taipei 114,","place":["Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"2026031721573176100_oyag051-B1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 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