{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T23:37:03Z","timestamp":1777246623524,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019346","name":"Instituto Nacional de Cancerolog\u00eda","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019346","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Financiamiento de Proyectos de Investigaci\u00f3n para la Salud Program","award":["FPIS-INCAN-4352"],"award-info":[{"award-number":["FPIS-INCAN-4352"]}]},{"DOI":"10.13039\/501100003141","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ciencia de Frontera Program","award":["CF-2023-I-2624"],"award-info":[{"award-number":["CF-2023-I-2624"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Testicular germ cell tumors (TGCT) are highly curable malignancies, yet the prognostic impact of host metabolic status remains underexplored, especially in non-Caucasian populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 2755 Mexican patients with TGCT treated at the Instituto Nacional de Cancerolog\u00eda (2007-2021). A Metabolic sub-cohort (n\u2009=\u2009586) and an Imaging sub-cohort (n\u2009=\u2009231) with baseline CT-derived lean mass index (LMI) were evaluated. Statistical analyses included multivariate Cox regression adjusted for IGCCCG risk, principal component analysis (PCA)-based clustering, and internal validation using bootstrapping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Multivariate Cox regression adjusted for IGCCCG risk identified LMI (HR 0.95, 95% CI 0.90-0.99, P\u2009=\u2009.047), serum albumin (HR 0.27, 95% CI 0.18-0.42, P\u2009&amp;lt;\u2009.001), and HDL cholesterol (HR 0.94, 95% CI 0.91-0.96, P\u2009&amp;lt;\u2009.001) as independently associated factors. PCA-based metabolic-nutritional risk profiles effectively stratified 5-year survival in patients with non-seminoma (from 16.1% in depleted profiles to 97.4% in preserved profiles) and seminoma (64.0% vs 100%). A reduced prognostic model (BMI, LMI, albumin) achieved a robust optimism-corrected AUC of 0.866.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Metabolic and body composition profiling provides prognostic discrimination complementary to the IGCCCG classification, suggesting the potential utility of incorporating objective nutritional assessments. Early identification of patients with metabolic vulnerability\u2014specifically hypoalbuminemia, skeletal muscle depletion, and altered lipid profiles\u2014could help guide personalized supportive strategies prioritizing nutritional and medical optimization to improve outcomes in TGCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag072","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:42:12Z","timestamp":1776253332000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolic profile and skeletal muscle as predictors of survival in testicular germ cell tumors"],"prefix":"10.1093","volume":"31","author":[{"given":"Alejandra","family":"Barr\u00f3n-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratorio de Regulaci\u00f3n de la Cromatina y Gen\u00f3mica, Instituto Nacional de Cancerolog\u00eda , Mexico City, 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14080,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e1n","family":"De-la-Rosa","sequence":"additional","affiliation":[{"name":"Laboratorio de Regulaci\u00f3n de la Cromatina y Gen\u00f3mica, Instituto Nacional de Cancerolog\u00eda , Mexico City, 14080,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clementina","family":"Castro-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Regulaci\u00f3n de la Cromatina y Gen\u00f3mica, Instituto Nacional de Cancerolog\u00eda , Mexico City, 14080,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Jim\u00e9nez-R\u00edos","sequence":"additional","affiliation":[{"name":"Departamento de Urolog\u00eda, Instituto Nacional de Cancerolog\u00eda , Mexico City, 14080,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Sobrevilla-Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Oncolog\u00eda M\u00e9dica, Instituto Nacional de Cancerolog\u00eda , Mexico City, 14080,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Santib\u00e1\u00f1ez-Andrade","sequence":"additional","affiliation":[{"name":"Laboratorio de Regulaci\u00f3n de la Cromatina y Gen\u00f3mica, Instituto Nacional de Cancerolog\u00eda , Mexico City, 14080,","place":["Mexico"]},{"name":"Departamento de Biolog\u00eda Celular, Facultad de Ciencias, UNAM , Mexico City, 04510,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-6586","authenticated-orcid":false,"given":"Rodrigo","family":"Gonz\u00e1lez-Barrios","sequence":"additional","affiliation":[{"name":"Laboratorio de Regulaci\u00f3n de la 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