{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:42:37Z","timestamp":1787870557052,"version":"build-2784847793"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The introduction of CDK4\/6 inhibitors (CDK4\/6i) has improved outcomes in hormone receptor-positive (HR+)\/HER2-negative metastatic breast cancer (mBC), including in patients with bone metastases. Assessing their comparative effectiveness in real-world settings is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, multicenter cohort study (January 2019\u2013December 2023; median follow-up 39\u2009months) evaluated the real-world progression-free survival (rwPFS) of abemaciclib, ribociclib, and palbociclib combined with endocrine therapy (ET) in HR+\/HER2- mBC patients with bone metastases. Overall survival (OS) was a secondary exploratory endpoint. A total of 1399 patients with ECOG PS 0\u20131 and at least 12\u2009months of follow-up were included. Analyses used propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) to adjust for confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Palbociclib showed shorter rwPFS (22\u2009months) compared to abemaciclib (32\u2009months; HR\u2009=\u20091.47, p\u2009=\u20090.001) and ribociclib (35\u2009months; HR\u2009=\u20091.49, p\u2009&amp;lt;\u20090.001). No significant difference was observed between abemaciclib and ribociclib. OS was also lower with palbociclib (47\u2009months) versus abemaciclib (60\u2009months; HR\u2009=\u20091.77, p\u2009&amp;lt;\u20090.001) and ribociclib (64\u2009months; HR\u2009=\u20091.69, p\u2009=\u20090.001). Results were consistent after PSM and IPTW adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Ribociclib and abemaciclib may provide superior rwPFS and OS compared to palbociclib in HR+\/HER2- mBC patients with bone metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag146","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:23:17Z","timestamp":1776079397000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparative real-world progression free survival of CDK4\/6 inhibitors in HR+\/HER2\u2212 breast cancer patients with bone metastases"],"prefix":"10.1093","volume":"31","author":[{"given":"Roberta","family":"Scafetta","sequence":"first","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]},{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Donato","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, \u201cG.Martino\u201d University Hospital, Via Consolare Valeria 1, 98124, Messina ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Gullotta","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Guarino","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fiore","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Santa Rosa Hospital, Department of Oncology and Hematology, Strada Sammartinese snc, 01100 Viterbo,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisana","family":"Sisca","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Speziale","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Troiano","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Foderaro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Universit\u00e0 Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128, Roma,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Venuti","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Antonio","family":"Vilardi","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico Via Alvaro del Portillo 200 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Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-9528","authenticated-orcid":false,"given":"Simona","family":"Pisegna","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University, Rome,","place":["Italy"]},{"name":"Medical Oncology Unit, Azienda Ospedaliero Universitaria Sant'Andrea, Via Di Grottarossa 1035-1039, Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-0113","authenticated-orcid":false,"given":"Carmen","family":"Criscitiello","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato-Oncology, University of Milan, Milano,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Chirco","sequence":"additional","affiliation":[{"name":"ASST Papa Giovanni XXIII-SC Oncologia, 24127 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Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Tiberi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Universit\u00e0 Politecnica Delle Marche, AOU delle Marche , Ancona,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"D\u2019Auria","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Vergati","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital , Rome,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mazzotta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medical Oncology Unit, Sandro Pertini Hospital , 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