{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:02:30Z","timestamp":1788998550874,"version":"build-2803163510"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Basal cell carcinoma (BCC) is common in older adults, many of whom are poor surgical candidates, especially for curved and cosmetically sensitive facial sites. High-dose-rate (HDR) surface brachytherapy is effective, but standard flat applicators may fit poorly and increase dose heterogeneity. Patient-specific 3D-printed applicators could improve conformity, yet geriatric BCC data are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the feasibility and 12-month outcomes of personalized 3D-printed HDR surface brachytherapy in geriatric patients with BCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective single-arm study, 15 patients aged \u226565\u2009years with histologically confirmed BCC (predominantly facial) who were unsuitable for surgery received HDR surface brachytherapy using custom 3D-printed applicators. Treatment delivered 51\u2009Gy in 17 fractions with CT-based planning. Repeat CT imaging evaluated applicator fit\/reproducibility and target coverage. Acute skin toxicity was graded by RTOG. At 12\u2009months, response was assessed clinically and dermoscopically; cosmesis and quality of life (Dermatology Life Quality Index [DLQI]) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients completed treatment. Positioning was highly reproducible (mean setup error &amp;lt;1\u2009mm) with &amp;gt;90% target dose coverage. At 12\u2009months, all lesions achieved complete remission, with no local recurrence on dermoscopy. Acute reactions were mostly mild (73% grade 1), with 13% grade 2 and 13% grade 3; no grade 4 toxicity or serious adverse events occurred. Cosmesis was favorable, and DLQI improved (mean, 10.5 pre-treatment vs 2.9 at 1\u2009year; P\u2009&amp;lt;\u2009.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Personalized 3D-printed HDR surface brachytherapy appears feasible and well tolerated in this small, single-center cohort of older patients with BCC, with favorable 1-year local control and quality-of-life improvement when surgery is contraindicated. However, the limited sample size and single-center design represent limitation, and the observed benefit should be regarded as suggestive rather than definitive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag206","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T11:37:29Z","timestamp":1779622649000},"source":"Crossref","is-referenced-by-count":1,"title":["Patient-specific 3D-printed HDR surface brachytherapy for basal cell carcinoma in older patients: prospective feasibility and imaging response"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-8021","authenticated-orcid":false,"given":"Piotr","family":"Sobolewski","sequence":"first","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]},{"name":"Chair and Clinic of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education , 02-507Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Koper","sequence":"additional","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Poltorak","sequence":"additional","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Banatkiewicz","sequence":"additional","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Kolos","sequence":"additional","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Poltorak","sequence":"additional","affiliation":[{"name":"Electrochemistry at Soft Interfaces Team, Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz , Tamka 12, 91-403 Lodz,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Szwast","sequence":"additional","affiliation":[{"name":"Department of Chemical and Process Engineering, Warsaw University of Technology , Warynskiego 1 , 00-645 Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Walecka","sequence":"additional","affiliation":[{"name":"The National Medical Institute of the Ministry of the Interior and Administration , Woloska 137 , 02-507 Warsaw,","place":["Poland"]},{"name":"Chair and Clinic of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education , 02-507Warsaw,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2026060700082408700_oyag206-B1","volume-title":"Updates on the Management of Non-Melanoma Skin Cancer (NMSC) in Healthcare","author":"Fahradyan","year":"2017"},{"key":"2026060700082408700_oyag206-B2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.clon.2019.08.009","article-title":"Current concepts in the surgical management of non-melanoma skin 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