{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:18:00Z","timestamp":1783106280417,"version":"3.54.6"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30CA077598"],"award-info":[{"award-number":["P30CA077598"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011539","name":"Masonic Cancer Center, University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011539","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Center for Advancing Translational Sciences of the National Institutes of Health","award":["UL1-TR002494"],"award-info":[{"award-number":["UL1-TR002494"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A treatment\u2019s time toxicity (measured using contact days) can decrease days spent at home (home days). We evaluated the minimum clinically important difference (MCID) and non-inferiority margin (NIM) of home days, and treatment acceptance when all additional survival time was spent in health care by surveying people with lived (patients, n\u2009=\u200942; informal care partners, n\u2009=\u200929) and professional (oncologists, n\u2009=\u20098) experience of advanced cancer. All 3 groups reported similar MCIDs and NIMs (6-month survival; median MCID range, 14-15; P\u2009=\u2009.79; median NIM range, 5-11; P\u2009=\u2009.14). Care partners (48%) and patients (21%) more often accepted 2-week survival gains without an increase in home days than oncologists (0%), P\u2009=\u2009.09. Caregivers reported altruism guided their responses, and clinicians\u2019 responses in stated-preference work may differ from revealed-preferences in the clinic. By empirically deriving MCID\/NIM for home days and evaluating treatment acceptance, this work will aid trial design and decision studies using an endpoint of home days.<\/jats:p>","DOI":"10.1093\/oncolo\/oyag246","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:06:48Z","timestamp":1782713208000},"source":"Crossref","is-referenced-by-count":0,"title":["Patient, care partner, and oncologist perspectives on clinically important survival thresholds after considering time toxicity in advanced cancer"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-4731","authenticated-orcid":false,"given":"Arjun","family":"Gupta","sequence":"first","affiliation":[{"name":"City of Hope Cancer Center , Phoenix, AZ,","place":["United States"]},{"name":"University of Minnesota , Minneapolis, MN,","place":["United 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University of Mississippi Medical Center , MS,","place":["United States"]},{"name":"John D Bower School of Population Health, University of Mississippi Medical Center , MS,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Breininger","sequence":"additional","affiliation":[{"name":"The Negative Space , Minneapolis, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-3653","authenticated-orcid":false,"given":"Christopher M","family":"Booth","sequence":"additional","affiliation":[{"name":"Division of Cancer Care and Epidemiology, Sinclair Cancer Research Institute , Kingston, ON,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M","family":"Parsons","sequence":"additional","affiliation":[{"name":"University of Minnesota , Minneapolis, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette Y","family":"Ziegenfuss","sequence":"additional","affiliation":[{"name":"Center for Evaluation and Survey Research, HealthPartners Institute , Bloomington, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-8464","authenticated-orcid":false,"given":"Rachel I","family":"Vogel","sequence":"additional","affiliation":[{"name":"University of Minnesota , Minneapolis, MN,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-4810","authenticated-orcid":false,"given":"Anne H","family":"Blaes","sequence":"additional","affiliation":[{"name":"University of Minnesota , Minneapolis, MN,","place":["United 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