{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:00:16Z","timestamp":1790190016983,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ9272"],"award-info":[{"award-number":["2024JJ9272"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ60613"],"award-info":[{"award-number":["2026JJ60613"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["W20243197"],"award-info":[{"award-number":["W20243197"]}]},{"name":"Health Research Project of Hunan Provincial Health Commission","award":["20258144"],"award-info":[{"award-number":["20258144"]}]},{"name":"High-Level Talent Scientific Research","award":["20240304101"],"award-info":[{"award-number":["20240304101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Reliable biomarkers for risk stratification and treatment monitoring in recurrent\/metastatic nasopharyngeal carcinoma (R\/M NPC) treated with first-line chemo-immunotherapy remain limited. This study evaluated the prognostic value of baseline computed tomography (CT)-derived body composition parameters and their early dynamic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center retrospective cohort study, patients with R\/M NPC receiving first-line chemo-immunotherapy were included. The primary endpoint was progression-free survival (PFS), and secondary endpoints included overall survival (OS), objective response rate (ORR), and disease control rate (DCR). Associations between body composition and outcomes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 199 patients were included, and 99 with post-treatment CT after 2 cycles were further analyzed for dynamic changes. Higher baseline skeletal muscle area (SMA) was independently associated with longer PFS (HR = 0.56; 95% CI, 0.37-0.85; P\u2009=\u20090.006) and OS (HR = 0.46; 95% CI, 0.23-0.93; P\u2009=\u20090.03), and with higher ORR (82.8% vs 70.0%; P\u2009=\u20090.033) and DCR (98.0% vs 91.0%; P\u2009=\u2009.031). During early treatment, a\u2009\u22641.3% decrease or an increase in SMA was independently associated with longer PFS (HR = 0.53; P\u2009=\u20090.045) and OS (HR = 0.27; P\u2009=\u20090.018). A greater decline in visceral adipose tissue density (\u0394VATD\u2009&amp;lt;\u2009\u22120.9%) was also associated with more favorable PFS and OS, whereas no significant difference in ORR was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline SMA and early changes in SMA and VATD have prognostic value in R\/M NPC treated with first-line chemo-immunotherapy. CT-based body composition assessment may serve as a practical imaging biomarker for risk re-stratification and individualized management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag355","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:31:27Z","timestamp":1788460287000},"source":"Crossref","is-referenced-by-count":0,"title":["Computed tomography-derived body composition and early changes predict outcomes of first-line chemo-immunotherapy in recurrent\/metastatic nasopharyngeal carcinoma"],"prefix":"10.1093","volume":"31","author":[{"given":"Xia","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]},{"name":"Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3693-2435","authenticated-orcid":false,"given":"Zhengzheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]},{"name":"Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , 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Central South University , Changsha, 410013,","place":["China"]},{"name":"Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]},{"name":"Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University , Changsha, 410013,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hunan 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