{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:54:24Z","timestamp":1791546864145,"version":"4.3.4"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Kentucky College of Medicine\u2019s Women in Medicine and Science (WIMS) Booster","id":[{"id":"https:\/\/ror.org\/02k3smh20","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University of Kentucky Self-prescribed Medicinal Cannabis Center","id":[{"id":"https:\/\/ror.org\/02k3smh20","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Research on self-administration of unprescribed cannabis remains limited because of its evolving legal status in the United States. We conducted, to our knowledge, the first fully independent tablet application\u2013executed oncology survey without research staff oversight in urban and rural radiation oncology practices. Objectives were to: (1) characterize symptoms motivating cannabis use, (2) compare urban and rural patterns of use, (3) assess concomitant use with opioids and gabapentin in an opioid-endemic region, and (4) evaluate associations with patient-reported quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>An IRB-approved, de-identified survey was administered to 237 adults receiving radiation therapy between July 2023 and February 2024, from an urban practice and a rural satellite of an NCI\/NCCN-designated cancer center. The survey assessed demographics, symptoms, quality of life, financial toxicity, and cannabis procurement. McNemar\u2019s test compared cannabis use before vs after cancer diagnosis; Fisher\u2019s exact and Cochran-Mantel-Haenszel tests evaluated associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 237 participants, 121 (51%) reported lifetime unprescribed medicinal cannabis use. Recent use after cancer diagnosis was reported by 35 patients (14.7%) vs 30 (12.7%) before diagnosis (P\u2009=\u20090.0625). Users most commonly reported cannabis for pain, nausea, anxiety, depression, poor appetite, and sleep disturbance; at least 80% reported symptom and quality-of-life improvement. Recent users were more likely to reside in urban than rural areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self-administration of unprescribed medicinal cannabis use was common across demographic groups and was primarily directed toward symptom management. This study demonstrates the feasibility of fully tablet-based research in rural oncology populations and provides novel data from an opioid-endemic region.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag370","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:35:47Z","timestamp":1790076947000},"source":"Crossref","is-referenced-by-count":0,"title":["Cannabis assessment in oncology patients\u2014evaluation survey: understanding usage patterns in a rural radiation cohort in Kentucky"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4509-5409","authenticated-orcid":false,"given":"Evans","family":"Amoah","sequence":"first","affiliation":[{"name":"Department of Radiation Medicine, University of Kentucky , Lexington, KY 40536,","place":["United States"]},{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed F","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, University of Kentucky , Lexington, KY 40536,","place":["United States"]},{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus E","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, University of Kentucky , Lexington, KY 40536,","place":["United States"]},{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy S","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, University of Kentucky , Lexington, KY 40536,","place":["United States"]},{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent J","family":"Shelton","sequence":"additional","affiliation":[{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]},{"name":"Department of Biostatistics, University of Kentucky , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aradhana","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine, University of Kentucky , Lexington, KY 40536,","place":["United States"]},{"name":"Markey Cancer Center , Lexington, KY 40536,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"2026100907313597100_oyag370-B1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.7326\/M22-0217","article-title":"U.S. Trends in registration for medical self-prescribed medicinal cannabis and reasons for use from 2016 to 2020: an observational study","volume":"175","author":"Boehnke","year":"2022","journal-title":"Ann Intern Med"},{"key":"2026100907313597100_oyag370-B2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/ropr.12460","article-title":"What do we know about opportunities and challenges for localities from self-prescribed medicinal cannabis legalization?","volume":"39","author":"Kavousi","year":"2022","journal-title":"Rev Policy Res"},{"key":"2026100907313597100_oyag370-B3","author":"\u201cHow Do Marijuana Laws Differ between States?\u201d","year":"2026"},{"key":"2026100907313597100_oyag370-B4","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jmir.2020.01.007","article-title":"Self-prescribed medicinal cannabis and radiation therapy: a scoping review of human clinical trials","volume":"51","author":"Rosewall","year":"2020","journal-title":"J Med Imaging Radiat 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