{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:54:27Z","timestamp":1791546867658,"version":"4.3.4"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acrokeratosis paraneoplastica (Bazex syndrome) is an obligate paraneoplastic dermatosis characterized by symmetrical acral psoriasiform lesions and nail dystrophy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a PRISMA-compliant systematic review of 99 publications (89 case reports, 10 case series) describing 106 patients to re-examine the syndrome\u2019s epidemiology, oncologic associations, clinical features, treatment response, and prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age at onset was 63.5\u2009years (median: 62.5\u2009years; interquartile range [IQR]: 57-70\u2009years); men comprised 72.6% (n\u2009=\u200977; 95% CI, 63.5%-80.2%), yielding a male-to-female ratio of 2.7:1. Squamous cell carcinoma accounted for 51.9% (55\/106; 95% CI, 42.5%-61.2%) of associated malignancies, followed by adenocarcinomas (18.9%; 95% CI, 12.6%-27.4%) and hematologic neoplasms (8.5%; 95% CI, 4.5%-15.4%). Cutaneous lesions preceded the cancer diagnosis in 80.6% (83\/103) of patients with reported chronology, with a median lead-time of 5\u2009months (IQR 2-10\u2009months). Nail involvement was documented in 73.6% (78\/106). Following oncologic therapy, complete cutaneous clearance occurred in 36.8% (95% CI, 28.2%-46.3%) and partial improvement in 30.2% (95% CI, 22.3%-39.5%) of cases. In univariable analyses, distant metastasis (P\u202f=\u202f.021) and an aerodigestive primary site (P\u202f=\u202f.026) were nominally associated with reported mortality, although neither remained significant after multiple-comparison correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bazex syndrome should be suspected in patients presenting with treatment-resistant acral psoriasiform lesions and nail dystrophy, prompting rigorous malignancy screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/oncolo\/oyag376","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:56:44Z","timestamp":1790164604000},"source":"Crossref","is-referenced-by-count":0,"title":["Acrokeratosis paraneoplastica (Bazex syndrome): a systematic review and quantitative analysis of 106 cases"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0906-6212","authenticated-orcid":false,"given":"Mustafa Sefa","family":"Isin","sequence":"first","affiliation":[{"name":"International School of Medicine, Istanbul Medipol University , Istanbul, 34815,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0822-6388","authenticated-orcid":false,"given":"Mehmet Berke","family":"Isler","sequence":"additional","affiliation":[{"name":"International School of Medicine, Istanbul Medipol University , Istanbul, 34815,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-1097","authenticated-orcid":false,"given":"Amor","family":"Khachemoune","sequence":"additional","affiliation":[{"name":"Premier Dermatology , Ashburn, VA 20147,","place":["USA"]},{"name":"Department of Dermatology, Istanbul Medipol University, International School of Medicine , Istanbul, 34214,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026100907313555200_oyag376-B1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1365-2230.1993.tb02247.x","article-title":"Bazex\u2019s syndrome (acrokeratosis paraneoplastica): first case report of association with a bladder carcinoma","volume":"18","author":"Arregui","year":"1993","journal-title":"Clin Exp Dermatol"},{"key":"2026100907313555200_oyag376-B2","first-page":"234","article-title":"Acrodermatite psoriasiforme d\u2018origine ind\u00e9termin\u00e9e (puis, apr\u00e8s enqu\u00eate, \u00c9pith\u00e9lioma de la langue) Dermatose \u00e9ryth\u00e9mato-squameuse avec Hyperk\u00e9ratose palmo-plantaire, Porectasies digitales et Cancer de la langue latent. Contribution \u00e0 l'\u00e9tude des Dermatoses monitrices de Cancer","volume":"43","author":"Gougerot","year":"1922","journal-title":"Paris Med"},{"key":"2026100907313555200_oyag376-B3","first-page":"182","article-title":"Syndrome paran\u00e9oplasique \u00e0 type d\u2019hyperk\u00e9ratose des extr\u00e9mit\u00e9s: gu\u00e9rison apr\u00e8s le traitement de l\u2019\u00e9pith\u00e9lioma laryng\u00e9","volume":"72","author":"Bazex","year":"1965","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"2026100907313555200_oyag376-B4","doi-asserted-by":"publisher","first-page":"e26411","DOI":"10.1016\/j.heliyon.2024.e26411","article-title":"Acrokeratosis neoplastica (Bazex syndrome): report of two cases and literature review","volume":"10","author":"Yamada","year":"2024","journal-title":"Heliyon"},{"key":"2026100907313555200_oyag376-B5","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/jdv.14199","article-title":"Acrokeratosis paraneoplastica (Bazex syndrome): a systematic 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