{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:55:13Z","timestamp":1786125313358,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Radiation-induced meningiomas are the most common radiation-induced neoplasms. They exhibit a distinct aggressive clinical behavior as rapid growth, recurrences, multiplicity, and malignant progression are common features.\n                    <jats:sup>1-4<\/jats:sup>\n                    Atypical histological findings and aberrant cytogenetics are increasingly identified.\n                    <jats:sup>5-7<\/jats:sup>\n                    Radical resection of aggressive radiation-induced meningiomas is the best treatment option and would offer the best chance for control of the disease. Wide bone and dural margins should be pursued in the resection. Parasellar extension creates significant surgical challenges. Cavernous sinus exploration through the multidirectional axis provided by the cranioorbital zygomatic approach allows radical resection of the tumor, cranial nerve decompression, and carotid artery preservation and control.\n                    <jats:sup>8-11<\/jats:sup>\n                    This article describes a cavernous sinus radiation-induced meningioma after radiation for Cushing disease. It demonstrates the details of the extra- and intradural exploration and dissection of the neurovascular structures in the cavernous sinus, with proximal and distal control of the carotid artery. However, even after radical resection, recurrence is a common finding in this malignant behavioral radiation-induced tumor.\n                  <\/jats:p>\n                  <jats:p>Patient consented for surgery.<\/jats:p>\n                  <jats:p>Image at 9:41 comes from the Science Museum Group, United Kingdom. Refer to the Wellcome blog post (archive). This image is licensed under the CC-BY 4.0 International license.<\/jats:p>","DOI":"10.1093\/ons\/opab195","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T15:23:22Z","timestamp":1623857002000},"page":"E231-E232","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Radiation-Induced Cavernous Sinus Meningioma: 2-Dimensional Operative Video"],"prefix":"10.1227","volume":"21","author":[{"given":"Antonio","family":"Aversa","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, National Institute of Cancer, Rio de Janeiro, Brazil"},{"name":"Department of Neurosurgery, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Al-Mefty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,9]]},"reference":[{"issue":"4","key":"bib1-20250822","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3171\/jns.1991.75.4.0564","article-title":"Radiation-induced meningiomas: experience at the Mount Sinai Hospital and review of the literature","volume":"75","author":"Harrison","year":"1991","journal-title":"J Neurosurg"},{"issue":"6","key":"bib2-20250822","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3171\/jns.2004.100.6.1002","article-title":"Radiation-induced meningiomas: clinical pathological, cytokinetic and cytogenetic characteristics","volume":"100","author":"Al-Mefty","year":"2004","journal-title":"J Neurosurg"},{"issue":"4","key":"bib3-20250822","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3171\/jns.1990.73.4.0502","article-title":"The long-term side effects of radiation therapy for benign brain tumors in adults","volume":"73","author":"Al-Mefty","year":"1990","journal-title":"J Neurosurg"},{"issue":"1","key":"bib4-20250822","first-page":"635","article-title":"Radiation-induced meningiomas: an exhaustive review of the literature","volume":"97","author":"Yamanaka","year":"2016","journal-title":"World Neurosurg"},{"issue":"2","key":"bib5-20250822","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<440::AID-CNCR27>3.0.CO;2-5","article-title":"A role for telomeric and centromeric instability in the progression of chromosome aberrations in meningioma patients","volume":"88","author":"Sawyer","year":"2000","journal-title":"Cancer"},{"issue":"2","key":"bib6-20250822","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3171\/jns.2004.101.2.0210","article-title":"Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings","volume":"101","author":"Al-Mefty","year":"2004","journal-title":"J Neurosurg"},{"issue":"3","key":"bib7-20250822","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3171\/2015.6.JNS15591","article-title":"Genomic landscape of intracranial meningiomas","volume":"125","author":"Bi","year":"2016","journal-title":"J Neurosurg"},{"issue":"1","key":"bib8-20250822","first-page":"248","article-title":"Extent of resection and overall survival for patients with atypical and malignant meningioma","volume":"130","author":"Aizer","year":"2015","journal-title":"Cancer"},{"issue":"2","key":"bib9-20250822","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3171\/jns.1994.81.2.0245","article-title":"Outcome of aggressive removal of cavernous sinus meningiomas","volume":"81","author":"DeMonte","year":"1994","journal-title":"J Neurosurg"},{"issue":"5","key":"bib10-20250822","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0090-3019(88)90200-5","article-title":"Surgery of tumors invading the cavernous sinus","volume":"30","author":"Al-Mefty","year":"1988","journal-title":"Surg Neurol"},{"key":"bib11-20250822","first-page":"154","article-title":"The cavernous carotid artery: preservation is the best means of reconstruction","volume":"42","author":"Bowles","year":"1995","journal-title":"Clin Neurosurg"}],"container-title":["Operative Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ons\/article-pdf\/21\/3\/E231\/39655421\/opab195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opab195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:53:34Z","timestamp":1786121614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opab195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1093\/ons\/opab195","relation":{},"ISSN":["2332-4252","2332-4260"],"issn-type":[{"value":"2332-4252","type":"print"},{"value":"2332-4260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"2021-01-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}