{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:27:51Z","timestamp":1788251271468,"version":"build-2803163510"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Microsurgical resection via open approaches is considered the main treatment modality for cranial base chondrosarcomas (CBCs). The use of endoscopic endonasal approaches (EEAs) has been rarely reported.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To present the endoscopic endonasal experience with CBCs at our institution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    Retrospective review of the medical records of 35 consecutive patients who underwent EEA for CBC resection between January 2004 and April 2013. Surgical outcomes and variables that might affect extent of resection, complications, and recurrence were analyzed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Forty-eight operations were performed (42 EEAs and 6 open approaches). Gross-total resection was achieved in 22 patients (62.9%), near total (\u226590% tumor resection) in 11 (31.4%). Larger tumors were associated with incomplete resection in univariate and multivariate analysis (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004, .015, respectively). In univariate analysis, tumors involving the lower clivus and cerebellopontine angle were associated with increased number of complications, especially postoperative cerebrospinal fluid leak (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .015) and new cranial neuropathy (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .037), respectively. Other major complications included 2 cases of meningitis and deep venous thrombosis, and 1 case of hydrocephalus and carotid injury. Involvement of the lower clivus, parapharyngeal space, and cervical spine required a combination of approaches to maximize tumor resection (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .017, .044, .017, respectively). No predictors were significantly associated with increased risk of recurrence. The average follow-up time was 44.6 \u00b1 31 months.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSIONS:<\/jats:bold>\n                    EEAs may be considered a good option for managing CBCs without significant posterolateral extension beyond the basal foramina and can be used in conjunction with open approaches for maximal resection with acceptable morbidity.\n                  <\/jats:p>","DOI":"10.1093\/ons\/opx020","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T03:55:53Z","timestamp":1489031753000},"page":"421-434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Endoscopic Endonasal Surgery for Cranial Base Chondrosarcomas"],"prefix":"10.1227","volume":"13","author":[{"given":"Francisco","family":"Vaz-Guimaraes","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Fernandez-Miranda","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Koutourousiou","sequence":"additional","affiliation":[{"name":"Department of Neurolog-ical Surgery, University of Louisville, Louisville, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Pathology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric W.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oto-laryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Department of Oto-laryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8]]},"reference":[{"issue":"3","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1634\/theoncologist.2007-0237","article-title":"The clinical approach towards chondrosarcoma","volume":"13","author":"Gelderblom","year":"2008","journal-title":"Oncologist"},{"issue":"1","key":"bib4-20240909","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jnnp.65.1.88","article-title":"Intracranial chondrosarcoma: review of the literature and report of 15 cases","volume":"65","author":"Korten","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"bib6-20240909","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nec.2012.08.002","article-title":"Skull base chondrosarcoma: evidence-based treatment paradigms","volume":"24","author":"Bloch","year":"2013","journal-title":"Neurosurg Clin N Am"},{"issue":"11","key":"bib7-20240909","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/cncr.23073","article-title":"Chordoma and chondrosarcoma. 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