{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:43:10Z","timestamp":1789785790394,"version":"4.0.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    As radiation has become an increasingly popular primary treatment option for sporadic vestibular schwannomas, there is a minority of tumors that do not respond favorably to radiation. Data on repeat radiosurgery are emerging, and salvage surgery has been associated with increased technical difficulty and poor facial nerve outcomes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To review the current literature and report our results with surgical resection of sporadic vestibular schwannomas that have failed primary radiation treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    This is a retrospective, single-surgeon case series of patients with sporadic vestibular schwannomas who failed primary radiation treatment and underwent subsequent surgical resection. We analyze demographics, clinical information, and intraoperative findings, focusing on facial nerve functional outcomes and extent of resection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Between 2006 and 2015, 10 patients with sporadic vestibular schwannomas whose only prior treatment was radiation underwent microsurgical resection. Eight of 10 patients had a postoperative House-Brackmann score of 1 at a median follow-up of 14 months, while 2 patients had House-Brackmann score of 4. Gross total resection was achieved in 7 of 10 cases. Near total resection was achieved in 2 cases, and only subtotal resection was achieved in 1 case.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Salvage surgery is a safe and effective option after failure of primary radiation and may offer benefits over repeat radiosurgery.\n                  <\/jats:p>","DOI":"10.1093\/ons\/opx023","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T19:29:19Z","timestamp":1491420559000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Surgery After Primary Radiation Treatment for Sporadic Vestibular Schwannomas: Case Series"],"prefix":"10.1227","volume":"13","author":[{"given":"Jonathan D.","family":"Breshears","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of California San Francisco, San Franci-sco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Osorio","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California San Francisco, San Franci-sco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Oto-laryngology, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor J.","family":"Barani","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip V.","family":"Theodosopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California San Francisco, San Franci-sco, 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