{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:52:39Z","timestamp":1789800759185,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Since the advent of neuromodulation, the role and efficacy of stereotactic radiosurgery (SRS) for chronic pain has not been carefully scrutinized.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To perform a systematic review to evaluate the clinical efficacy, both short- and long-term, of SRS for the treatment of chronic intractable pain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    A systematic search in PubMed, Web of Science, and PsycINFO was performed using keywords and controlled vocabulary. The search included peer-reviewed articles reporting clinical outcomes of SRS for chronic pain with a minimum 3-mo follow-up for nonmalignant and 1 mo for malignant pain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Six articles (113 patients) were evaluated on the basis of radiation target (thalamus vs pituitary) and pain etiology (malignant vs nonmalignant). Across studies, at least 35% of patients were reported to have lasting significant pain relief. By cohort, clinical success was achieved in 51% of pituitary SRS, at least 23% of thalamic SRS, 39% of nonmalignant, and at least 33% of malignant pain patients. Adverse events were noted in 21% of patients; the majority related to hormonal deficits from pituitary SRS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Despite decreased utilization, SRS is effective for select patients with chronic pain and is associated with an acceptable complication rate. Pituitary SRS is superior in patients with cancer-related pain (87% success), while thalamic SRS is superior in patients with nonmalignant pain (65% success). Because reports of SRS for pain largely stem from a period before the common use of neuromodulatory and intrathecal therapies, the efficacy in patients who fail such therapies remains unclear and requires further characterization.\n                  <\/jats:p>","DOI":"10.1093\/ons\/opx095","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T01:41:55Z","timestamp":1494985315000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Stereotactic Radiosurgery for the Treatment of Chronic Intractable Pain: A Systematic Review"],"prefix":"10.1227","volume":"13","author":[{"given":"Dustin G.","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Pouratian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California"},{"name":"Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,10]]},"reference":[{"issue":"6","key":"bib1-20240909","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11606-008-0570-8","article-title":"Update in pain medicine","volume":"23","author":"Alford","year":"2008","journal-title":"J Gen Intern Med"},{"issue":"No. RR-1","key":"bib2-20240909","first-page":"1","article-title":"CDC guideline for prescribing opioids for chronic pain \u2014 United States, 2016","volume":"65","author":"Dowell","year":"2016","journal-title":"MMWR Recomm Rep 2016"},{"issue":"15","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.2014.12986","article-title":"Relieving pain in America: insights from an Institute of Medicine committee","volume":"312","author":"Dzau","year":"2014","journal-title":"JAMA"},{"issue":"8","key":"bib4-20240909","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jpain.2015.05.002","article-title":"Estimates of pain prevalence and severity in adults: United States, 2012","volume":"16","author":"Nahin","year":"2015","journal-title":"J Pain"},{"key":"bib5-20240909","doi-asserted-by":"crossref","DOI":"10.1111\/papr.12438","article-title":"Clinical uses of intrathecal therapy and its placement in the pain care algorithm","author":"Pope","year":"2016","journal-title":"Pain Pract"},{"issue":"8","key":"bib6-20240909","first-page":"585","article-title":"Cerebral radiosurgery I. 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