{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:46:22Z","timestamp":1786124782295,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Severe cervical kyphosis in the setting of neurofibromatosis type 1 (NF1) is a rare manifestation of the disease in the pediatric population. Dystrophic and immature bone complicate the placement of hardware necessary for surgical correction of alignment and a review of the literature yields 4 cases of pediatric patients with NF1 requiring surgical intervention in which the youngest patient was 10 yr old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report the case of an 11-mo-old female with NF1 who presented with a plexiform cervical neurofibroma and focal cervical kyphosis. A comprehensive review of the literature and a detailed description of nonsurgical and surgical management for this patient population is described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A literature review was completed for article reviewing management of pediatric patients with cervical spine injuries and NF1. The patient's chart was reviewed and the patient was followed for a year to provide adequate follow-up. Institutional Review Board (IRB)\/ethics committee approval and patient consent were neither required nor sought for this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The literature was reviewed, summarized, and utilized for operative planning and postoperative management. Postoperative imaging and 1-yr follow-up imaging showed anterior construct and lateral mass fusion, restoration of cervical alignment, and no neurological deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This is the youngest reported patient to have surgical cervical kyphosis correction in the setting of NF1. A review of the literature helped develop a long-term plan and shape a novel same-day front-back-front approach to restore alignment that will be of use to teams managing these complex patients in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opx219","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T08:58:38Z","timestamp":1509008318000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Correction of Progressive Severe Cervical Kyphosis in a 21-Month-Old Patient With NF1: Surgical Technique and Review of Literature"],"prefix":"10.1227","volume":"15","author":[{"given":"Krishanthan","family":"Vigneswaran","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A","family":"Sribnick","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Reisner","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgical Associates, Children's Healthcare of Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Chern","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgical Associates, Children's Healthcare of Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,7]]},"reference":[{"issue":"2","key":"bib1-20240909","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0967-5868(03)00003-1","article-title":"A neurofibromatosis type 1 patient with severe kyphoscoliosis and intrathoracic meningocele","volume":"10","author":"Ebara","year":"2003","journal-title":"J Clin Neurosci"},{"issue":"3","key":"bib2-20240909","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/BPB.0b013e32833561c7","article-title":"Significance of surgical treatment for severe dystrophic changes in the cervical spine associated with neurofibromatosis type I: a case report","volume":"19","author":"Inoue","year":"2010","journal-title":"J Pediatr Orthop B"},{"issue":"3","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3171\/2012.11.SPINE12417","article-title":"Surgical correction of severe cervical kyphosis in patients with neurofibromatosis Type 1","volume":"18","author":"Kawabata","year":"2013","journal-title":"J Neurosurg Spine"},{"key":"bib4-20240909","article-title":"Eight-year follow-up findings of surgical treatment for severe dystrophic changes in the cervical spine associated with neurofibromatosis type I: a case report","author":"Kita","year":"2016","journal-title":"J Pediatr Orthop B"},{"issue":"1","key":"bib5-20240909","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3171\/2010.9.SPINE091015","article-title":"Surgical treatment of severe cervical dystrophic kyphosis due to neurofibromatosis Type 1: a review of 8 cases","volume":"14","author":"Ma","year":"2011","journal-title":"J Neurosurg Spine"},{"issue":"4","key":"bib6-20240909","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1302\/0301-620X.74B4.1624519","article-title":"Neurofibromatosis of the cervical spine. 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