{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:51:08Z","timestamp":1786125068702,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":732,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>There is a rare type of vestibular schwannoma, scarcely discussed in the literature, known as a hypervascular vestibular schwannoma (HVS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate its biological characteristics, angiographical classification, surgical outcomes, and the significance for surgical consideration, using a large series of this clinical entity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The definition for HVS in this study was the tumor stain from the vertebrobasilar system (VBS) in angiography. The authors conducted a retrospective analysis of 36 patients who were angiographically diagnosed with HVS and underwent surgery between 2008 and 2015. Their biological findings and their surgical outcomes were compared with non-HVS subjects. With regard to the tumor feeders and AV shunt, we classified HVS into 5 types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>HVS occurred more commonly in younger subjects (mean: 39.4 yr), as a larger solid tumor with multiple flow voids (mean: 34.1 mm), and involved higher levels of cerebrospinal fluid protein (mean: 202 mg\/dl) and a higher MIB1-index (mean: 4.3%). The average resection rate for these 36 cases was 95.3%, and recurrence was seen in 6 cases (16.7%). Compared with non-HVS, the extent of tumor resection was significantly lower, and the recurrence rate was significantly higher. Especially in HVS type 2B (the tumor stain is fed by the VBS and the external carotid artery, with an arteriovenous shunt from the VBS), the recurrence-free survival duration was significantly shorter compared with other HVS types and non-HVS, and HVS type 2B exhibited an identifiable risk factor for recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>HVS have the distinct clinical characteristics compared with those of non-HVS subjects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opx246","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T22:27:25Z","timestamp":1512685645000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Hypervascular Vestibular Schwannomas: Clinical Characteristics, Angiographical Classification, and Surgical Considerations"],"prefix":"10.1227","volume":"15","author":[{"given":"Yu","family":"Teranishi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Stroke Center, Tokyo Metropolitan Police Hospital, Tokyo, Japan"},{"name":"Department of Neurosurgery, University of Tokyo Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stroke Center, Tokyo Metropolitan Police Hospital, Tokyo, Japan"},{"name":"Department of Neurosurgery, Tokyo Medical University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Sora","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stroke Center, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Stroke Center, Tokyo Metropolitan Police Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9]]},"reference":[{"issue":"2","key":"bib1-20240909","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF00342598","article-title":"Angiographic diagnosis of acoustic neurinomas and meningiomas in the cerebellopontine angle\u2013a reappraisal","volume":"19","author":"Numaguchi","year":"1980","journal-title":"Neuroradiology."},{"issue":"3-4","key":"bib2-20240909","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF01402076","article-title":"Blood supply of acoustic neurinomas","volume":"52","author":"Perneczky","year":"1980","journal-title":"Acta Neurochir."},{"issue":"4","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00337566","article-title":"Angiographic diagnosis of acoustic neurinomas: analysis of 30 lesions","volume":"2","author":"Takahashi","year":"1971","journal-title":"Neuroradiology."},{"issue":"1","key":"bib4-20240909","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1148\/118.1.83","article-title":"Participation of the external and internal carotid arteries in the blood supply of acoustic neurinomas","volume":"118","author":"Theron","year":"1976","journal-title":"Radiology."},{"issue":"6","key":"bib5-20240909","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/neurintsurg-2011-010116","article-title":"Direct intraoperative confirmation of penetration of ethylene vinyl alcohol copolymer (Onyx) into the vasa nervosa of the facial nerve","volume":"4","author":"Chen","year":"2012","journal-title":"J Neurointervent Surg."},{"issue":"2","key":"bib6-20240909","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.nic.2007.12.010","article-title":"Arterial Vascularization of the cranial nerves.","volume":"18","author":"Ozanne","year":"2008","journal-title":"Neuroimaging Clin N Am."},{"issue":"5","key":"bib7-20240909","first-page":"387","article-title":"Anatomy of the vestibulo-acoustico-facial neurovascular pedicle. 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