{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:35:46Z","timestamp":1791387346740,"version":"4.3.3"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":575,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Oper. Neurosurg.","ONSURG"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Transsphenoidal surgery (TSS) for pituitary adenomas (PAs) is performed on elderly patients with increasing frequency. More research is necessary to assess the risk factors that are associated with TSS in an aging population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To perform a retrospective study on postoperative safety outcomes following TSS in the elderly population stratified by decade of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective chart review of the USC Pituitary Database was conducted to identify patients\u00a0\u226570 yr, who underwent TSS for PAs between 1995 and 2017. Surgical outcomes were analyzed in elderly (\u226570 yr) vs nonelderly (&lt;70 yr) patients. Elderly patients were additionally stratified according to age 70 to 79 vs\u00a0\u226580 yr.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The cohorts included 115 elderly patients (70-79 yr: 94 patients; \u226580 yr: 21 patients) and 770 nonelderly patients. Elderly patients presented with more vision loss (62% vs 38%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001), dizziness (17% vs 6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.0001) and altered mental status (7.3% vs 3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.0451). Overall rates of surgical, medical, and endocrine complications were similar; however, elderly patients had significantly higher rates of postoperative hyponatremia (9.3% vs 4.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.0401) and lower rates of transient diabetes insipidus (0.9% vs 7.9%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.0038). Patients\u00a0\u2265\u00a080 yr had significantly more surgical complications (26.3%) compared to the 70 to 79 group (7.87%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.021) and\u00a0&lt;70 group (12.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Patients\u00a0&gt;70 yr are appropriate surgical candidates for TSS given the similar safety outcomes as younger patients. Given the higher propensity for surgical complications; however, a higher level of operative selectivity should be maintained in octogenarian patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opy109","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T07:06:09Z","timestamp":1527145569000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Outcomes Following Transsphenoidal Pituitary Surgery in the Elderly: A Retrospective Single-Center Review"],"prefix":"10.1227","volume":"16","author":[{"given":"Zoe","family":"Memel","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsi","family":"Chesney","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj J","family":"Pangal","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A","family":"Bonney","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, Keck School of Medicine of USC, Los Angeles, California"},{"name":"USC Pituitary Center, USC Keck School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Zada","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Keck School of Medicine of USC, Los Angeles, California"},{"name":"USC Pituitary Center, USC Keck School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,3]]},"reference":[{"issue":"2","key":"bib1-20240909","first-page":"441","article-title":"Pathobiology of pituitary adenomas and carcinomas","volume":"59","author":"Scheithauer","year":"2006","journal-title":"Acta Neurochir"},{"issue":"6","key":"bib2-20240909","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.wneu.2015.08.035","article-title":"Pure endoscopic endonasal transsphenoidal approach for nonfunctioning pituitary adenomas in the elderly: surgical outcomes and complications in 158 patients","volume":"84","author":"Zhan","year":"2015","journal-title":"World 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