{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:33:41Z","timestamp":1789540421893,"version":"build-2803163510"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"suppl_1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":449,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In this supplement, we build on work previously published under the Human Connectome Project. Specifically, we show a comprehensive anatomic atlas of the human cerebrum demonstrating all 180 distinct regions comprising the cerebral cortex. The location, functional connectivity, and structural connectivity of these regions are outlined, and where possible a discussion is included of the functional significance of these areas. In part 4, we specifically address regions relevant to the medial frontal lobe, anterior cingulate gyrus, and orbitofrontal cortex.<\/jats:p>","DOI":"10.1093\/ons\/opy257","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T04:04:58Z","timestamp":1538021098000},"page":"S122-S174","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["A Connectomic Atlas of the Human Cerebrum\u2014Chapter 4: The Medial Frontal Lobe, Anterior Cingulate Gyrus, and Orbitofrontal Cortex"],"prefix":"10.1227","volume":"15","author":[{"given":"Cordell M","family":"Baker","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D","family":"Burks","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K","family":"Conner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad A","family":"Glenn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goksel","family":"Sali","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tressie M","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Battiste","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"O\u2019Donoghue","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E","family":"Sughrue","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"},{"name":"Department of Neurosurgery, Prince of Wales Private Hospital, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,12]]},"reference":[{"issue":"4","key":"bib1-20240909","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/scan\/nss023","article-title":"Role of right pregenual anterior cingulate cortex in self-conscious emotional reactivity","volume":"8","author":"Sturm","year":"2013","journal-title":"Soc Cogn Affect Neurosci"},{"issue":"1","key":"bib2-20240909","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/brain\/118.1.279","article-title":"Contributions of anterior cingulate cortex to behaviour","volume":"118","author":"Devinsky","year":"1995","journal-title":"Brain"},{"issue":"08","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1017\/S1092852900013754","article-title":"The subgenual anterior cingulate cortex in mood disorders","volume":"13","author":"Drevets","year":"2008","journal-title":"CNS Spectr"},{"issue":"4","key":"bib4-20240909","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1523\/JNEUROSCI.3328-08.2009","article-title":"Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization","volume":"29","author":"Beckmann","year":"2009","journal-title":"J Neurosci"},{"issue":"6","key":"bib5-20240909","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/cne.21684","article-title":"Cytology and receptor architecture of human anterior cingulate cortex","volume":"508","author":"Palomero-Gallagher","year":"2008","journal-title":"J Comp Neurol"},{"issue":"7615","key":"bib6-20240909","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature18933","article-title":"A multi-modal parcellation of human cerebral cortex","volume":"536","author":"Glasser","year":"2016","journal-title":"Nature"},{"issue":"3","key":"bib8-20240909","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/cne.903590310","article-title":"Human cingulate cortex: surface features, flat maps, and cytoarchitecture","volume":"359","author":"Vogt","year":"1995","journal-title":"J Comp Neurol"},{"issue":"4","key":"bib9-20240909","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jchemneu.2003.09.004","article-title":"Cytology of human dorsal midcingulate and supplementary motor cortices","volume":"26","author":"Vogt","year":"2003","journal-title":"J Chem Neuroanat"},{"issue":"3","key":"bib10-20240909","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.neubiorev.2013.01.002","article-title":"Localization of function in anterior cingulate cortex: from psychosurgery to functional neuroimaging","volume":"37","author":"Gasquoine","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"bib11-20240909","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1073\/pnas.012470999","article-title":"Dorsal anterior cingulate cortex: a role in reward-based decision making","volume":"99","author":"Bush","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"bib12-20240909","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1364-6613(00)01483-2","article-title":"Cognitive and emotional influences in anterior cingulate cortex","volume":"4","author":"Bush","year":"2000","journal-title":"Trends Cogn Sci"},{"issue":"1-3","key":"bib13-20240909","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jphysparis.2015.02.002","article-title":"The role of supplementary eye field in goal-directed behavior","volume":"109","author":"Stuphorn","year":"2015","journal-title":"J Physiol Paris"},{"issue":"3","key":"bib14-20240909","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1460-9568.1999.00518.x","article-title":"Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns","volume":"11","author":"Petrides","year":"1999","journal-title":"Eur J Neurosci"},{"issue":"1481","key":"bib15-20240909","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1098\/rstb.2007.2095","article-title":"Function and localization within rostral prefrontal cortex (area 10)","volume":"362","author":"Burgess","year":"2007","journal-title":"Philos Trans R Soc B: Biol Sci"},{"issue":"2","key":"bib16-20240909","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tics.2010.12.004","article-title":"Value, pleasure and choice in the ventral prefrontal cortex","volume":"15","author":"Grabenhorst","year":"2011","journal-title":"Trends Cogn Sci"},{"issue":"5","key":"bib17-20240909","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pneurobio.2004.03.006","article-title":"The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology","volume":"72","author":"Kringelbach","year":"2004","journal-title":"Prog Neurobiol"},{"issue":"6","key":"bib18-20240909","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.neuron.2014.10.049","article-title":"The orbitofrontal oracle: cortical mechanisms for the prediction and evaluation of specific behavioral outcomes","volume":"84","author":"Rudebeck","year":"2014","journal-title":"Neuron"},{"issue":"1","key":"bib19-20240909","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1196\/annals.1401.018","article-title":"What can an orbitofrontal cortex-endowed animal do with smells?","volume":"1121","author":"Gottfried","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"bib20-20240909","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cne.10609","article-title":"Architectonic subdivision of the human orbital and medial prefrontal cortex","volume":"460","author":"Ongur","year":"2003","journal-title":"J Comp Neurol"},{"issue":"4","key":"bib21-20240909","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cne.903630409","article-title":"Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys","volume":"363","author":"Carmichael","year":"1995","journal-title":"J Comp Neurol"},{"issue":"4","key":"bib22-20240909","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ijo.2010.155","article-title":"Taste, olfactory and food texture reward processing in the brain and obesity","volume":"35","author":"Rolls","year":"2011","journal-title":"Int J Obes"},{"issue":"6","key":"bib23-20240909","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.conb.2006.07.004","article-title":"Prefrontal involvement in the regulation of emotion: convergence of rat and human studies","volume":"16","author":"Quirk","year":"2006","journal-title":"Curr Opin Neurobiol"},{"issue":"2","key":"bib24-20240909","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib25-20240909","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/brain.2015.0379","article-title":"Interactions among the brain default-mode, salience, and central-executive networks during perceptual decision-making of moving dots","volume":"6","author":"Chand","year":"2016","journal-title":"Brain Connect"},{"issue":"49","key":"bib26-20240909","doi-asserted-by":"crossref","first-page":"19944","DOI":"10.1073\/pnas.1311772110","article-title":"Causal interactions between fronto-parietal central executive and default-mode networks in humans","volume":"110","author":"Chen","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"bib27-20240909","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuroimage.2014.05.052","article-title":"The salience network is responsible for switching between the default mode network and the central executive network: replication from DCM","volume":"99","author":"Goulden","year":"2014","journal-title":"Neuroimage"},{"key":"bib28-20240909","doi-asserted-by":"crossref","DOI":"10.1007\/s11682-018-9838-8","article-title":"Common and distinct changes of default mode and salience network in schizophrenia and major depression","author":"Shao","year":"2018","journal-title":"Brain Imaging Behav"},{"key":"bib29-20240909","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jpsychires.2017.04.007","article-title":"Resting state brain network function in major depression - Depression symptomatology, antidepressant treatment effects, future research","volume":"92","author":"Brakowski","year":"2017","journal-title":"J Psychiatr Res"},{"key":"bib30-20240909","first-page":"1","article-title":"Preliminary findings of altered functional connectivity of the default mode network linked to functional outcomes one year after pediatric traumatic brain injury","author":"Stephens","year":"2017","journal-title":"Dev Neurorehabil"},{"issue":"5","key":"bib31-20240909","doi-asserted-by":"crossref","DOI":"10.1007\/s10072-018-3306-5","article-title":"Aberrant default mode network in amnestic mild cognitive impairment: a meta-analysis of independent component analysis studies","author":"Wang","year":"2018","journal-title":"Neurol Sci"},{"issue":"1","key":"bib32-20240909","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1186\/s12880-017-0221-9","article-title":"Alterations in resting-state functional connectivity of the default mode network in amnestic mild cognitive impairment: an fMRI study","volume":"17","author":"Li","year":"2017","journal-title":"BMC Med Imaging"},{"issue":"6","key":"bib33-20240909","first-page":"476","article-title":"The default mode network in Autism","volume":"2","author":"Padmanabhan","year":"2017","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"issue":"6","key":"bib34-20240909","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.3171\/2016.5.JNS153006","article-title":"A method for safely resecting anterior butterfly gliomas: the surgical anatomy of the default mode network and the relevance of its preservation","volume":"126","author":"Burks","year":"2017","journal-title":"J Neurosurg"},{"issue":"28","key":"bib35-20240909","doi-asserted-by":"crossref","first-page":"9781","DOI":"10.1073\/pnas.0711791105","article-title":"Consistency and functional specialization in the default mode brain network","volume":"105","author":"Harrison","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"bib36-20240909","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hbm.22234","article-title":"The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system","volume":"35","author":"Ward","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"bib37-20240909","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/ejn.12389","article-title":"The origin of projections from the posterior cingulate and retrosplenial cortices to the anterior, medial dorsal and laterodorsal thalamic nuclei of macaque monkeys","volume":"39","author":"Aggleton","year":"2014","journal-title":"Eur J Neurosci"},{"key":"bib38-20240909","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuroimage.2014.11.009","article-title":"Subspecialization in the human posterior medial cortex","volume":"106","author":"Bzdok","year":"2015","journal-title":"Neuroimage"},{"issue":"1","key":"bib39-20240909","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"issue":"2","key":"bib40-20240909","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neuroimage.2005.07.048","article-title":"Cytology and functionally correlated circuits of human posterior cingulate areas","volume":"29","author":"Vogt","year":"2006","journal-title":"Neuroimage"},{"issue":"44","key":"bib41-20240909","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-Club organization of the human connectome","volume":"31","author":"van den Heuvel","year":"2011","journal-title":"J Neurosci"},{"key":"bib42-20240909","first-page":"1","article-title":"Anatomy and white matter connections of the orbitofrontal gyrus","author":"Burks","year":"2017","journal-title":"J Neurosurg"}],"container-title":["Operative Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ons\/article-pdf\/15\/suppl_1\/S122\/31192307\/opy257.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/01787389-201812001-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:54:47Z","timestamp":1786121687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01787389-201812001-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,27]]},"references-count":41,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1093\/ons\/opy257","relation":{},"ISSN":["2332-4252","2332-4260"],"issn-type":[{"value":"2332-4252","type":"print"},{"value":"2332-4260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,27]]},"assertion":[{"value":"2018-05-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}