{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:45:13Z","timestamp":1786124713650,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The minimally invasive parafascicular approach provides a surgical corridor to reach deep lesions with minimal impact on the surrounding brain tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the safety and efficacy of this approach utilizing the image-guided tubular BrainPath system (NICO Corp, Indianapolis, Indiana) for the resection of deep and subcortical supratentorial cerebral cavernous malformations (CCMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of patients who presented with subcortical CCMs treated with the BrainPath system. Patient demographics, clinical presentation, procedural complications, and clinical and imaging follow-up information were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Six patients were identified between December 2014 and November 2017 at a large volume academic institution in the United States. There were 3 males and 3 female patients with a median age of 25 yr. Locations included frontal, temporal, and parietal lobes. In selected cases, the fiber-sparing trajectory imposed a longer approach than the closest distance to the brain surface. Except for 1 patient who suffered from surgical wound dehiscence, there were no operative complications in any of the cases. All patients remained neurologically stable postoperatively with a mean follow-up of 20 moh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This small series suggests that the use of a minimally invasive surgical approach to CCMs utilizing the image-guided parafascicular tubular BrainPath system is feasible, safe, and effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opy389","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T03:58:11Z","timestamp":1545191891000},"page":"348-353","source":"Crossref","is-referenced-by-count":8,"title":["Minimally Invasive Parafascicular Surgery for Resection of Cerebral Cavernous Malformations Utilizing Image-Guided BrainPath System"],"prefix":"10.1227","volume":"17","author":[{"given":"Oded","family":"Goren","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J","family":"Griessenauer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania"},{"name":"Research Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian O","family":"Bohan","sequence":"additional","affiliation":[{"name":"Geisinger Commonwealth School of Medicine, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens M","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,10]]},"reference":[{"issue":"6","key":"bib1-20231017","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jocn.2015.01.004","article-title":"Endoport-assisted microsurgical resection of cerebral cavernous malformations","volume":"22","author":"Ding","year":"2015","journal-title":"J Clin Neurosci"},{"issue":"6","key":"bib2-20231017","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3171\/2015.12.JNS152185","article-title":"Transulcal parafascicular minimally invasive approach to deep and subcortical cavernomas: technical note","volume":"125","author":"Scranton","year":"2016","journal-title":"J Neurosurg"},{"issue":"4","key":"bib3-20231017","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.biopsych.2008.03.024","article-title":"Classification of white matter lesions on magnetic resonance imaging in elderly persons","volume":"64","author":"Kim","year":"2008","journal-title":"Biol Psychiat"},{"issue":"2","key":"bib4-20231017","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1474-4422(15)00303-8","article-title":"Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data","volume":"15","author":"Horne","year":"2016","journal-title":"Lancet Neurol"},{"issue":"5","key":"bib5-20231017","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jocn.2011.08.024","article-title":"Characteristics of cavernomas of the brain and spine","volume":"19","author":"Kivelev","year":"2012","journal-title":"J Clin Neurosci"},{"issue":"12","key":"bib6-20231017","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11886-017-0931-1","article-title":"Clinical management of cavernous malformations","volume":"19","author":"Flemming","year":"2017","journal-title":"Curr Cardiol Rep"},{"issue":"2","key":"bib7-20231017","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3171\/jns.1997.87.2.0190","article-title":"Cerebral cavernous malformations: natural history and prognosis after clinical deterioration with or without hemorrhage","volume":"87","author":"Porter","year":"1997","journal-title":"J Neurosurg"},{"issue":"4","key":"bib8-20231017","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jocn.2011.08.015","article-title":"Treatment strategies in cavernomas of the brain and spine","volume":"19","author":"Kivelev","year":"2012","journal-title":"J Clin Neurosci"},{"issue":"Suppl 2","key":"bib9-20231017","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.surneu.2009.05.031","article-title":"Surgical treatment of brainstem cavernous malformations","volume":"72","author":"Garrett","year":"2009","journal-title":"Surg Neurol"},{"issue":"1","key":"bib10-20231017","first-page":"149","article-title":"Future perspectives in stereotactic neurosurgery: stereotactic microsurgical removal of deep brain tumors","volume":"33","author":"Kelly","year":"1989","journal-title":"J Neurosurg Sci"},{"issue":"4 Suppl 2","key":"bib11-20231017","first-page":"334","article-title":"Stereotactic minimally invasive tubular retractor system for deep brain lesions","volume":"63","author":"Greenfield","year":"2008","journal-title":"Neurosurgery"},{"issue":"4","key":"bib12-20231017","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3171\/2015.4.JNS142576","article-title":"Utility of tubular retractors to minimize surgical brain injury in the removal of deep intraparenchymal lesions: a quantitative analysis of FLAIR hyperintensity and apparent diffusion coefficient maps","volume":"124","author":"Bander","year":"2016","journal-title":"J Neurosurg"},{"issue":"01","key":"bib13-20231017","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0031-1273734","article-title":"Minimally invasive trans-portal resection of deep intracranial lesions","volume":"54","author":"Raza","year":"2011","journal-title":"Minim Invas Neurosur"},{"key":"bib14-20231017","first-page":"519","article-title":"Technology that achieves the Triple Aim: an economic analysis of the BrainPathTM approach in neurosurgery","volume":"9","author":"Norton","year":"2017","journal-title":"Clin Outcomes Res CEOR"}],"container-title":["Operative Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opy389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:44:39Z","timestamp":1786121079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opy389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1093\/ons\/opy389","relation":{},"ISSN":["2332-4252","2332-4260"],"issn-type":[{"value":"2332-4252","type":"print"},{"value":"2332-4260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}