{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:45:33Z","timestamp":1786124733893,"version":"build-2736575974"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>While recent data has demonstrated the utility of lumbar pedicle screws for the treatment of vertebral osteomyelitis, the data are limited for thoracic pedicle screws.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To investigate the effectiveness of thoracic pedicle screws for the surgical treatment of vertebral osteomyelitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective review of all operations performed by 2 spinal neurosurgeons from 1999 to 2012 yielded 30 cases of vertebral osteomyelitis that were treated with thoracic pedicle screws. Sixteen (53%) of which underwent combined anterior and posterior fusion and 14 patients (47%) underwent standalone posterior fusion. Postoperative records were analyzed for pertinent clinical, laboratory, and radiographic data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of the 30 patients, 21 were males (70%), 8 were females (27%), and 1 was transsexual (3%). The mean age was 47 yr (range 18-69). The most common organism cultured was\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      in 12 cases (50%). The mean patient stay in the hospital was 12.4 d after surgery (range 5-38 d). The mean antibiotic duration after discharge was 8 wk (range 1-24 wk). Of the 25 patients with long-term follow-up (mean, 49 mo), 92% had improved back pain (6\/25 marked improvement, 17\/25 complete resolution), 83% had improved muscle weakness (8\/18 marked improvement, 7\/18 complete resolution), and 100% had improved urinary incontinence (3\/8 marked improvement, 5\/8 complete resolution). Two patients (7%) required additional surgical revision due to instrumentation failure or wound infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study demonstrates the efficacy of utilizing thoracic pedicle screws as a primary intervention to treat vertebral osteomyelitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opy398","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T13:46:51Z","timestamp":1548337611000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Treatment With Thoracic Pedicle Screw Fixation of Vertebral Osteomyelitis With Long-Term Follow-up"],"prefix":"10.1227","volume":"17","author":[{"given":"Robert F","family":"Heary","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira M","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,11]]},"reference":[{"issue":"10","key":"bib1-20240909","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1086\/340102","article-title":"Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals","volume":"34","author":"McHenry","year":"2002","journal-title":"Clin Infect Dis"},{"issue":"7","key":"bib2-20240909","first-page":"527","article-title":"Vertebral osteomyelitis in Goteborg, Sweden: a retrospective study of patients during 1990\u201395","volume":"33","author":"Beronius","year":"2001","journal-title":"Scand J Infect Dis"},{"issue":"5","key":"bib3-20240909","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1017\/S0950268807008850","article-title":"Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002\u20132003","volume":"136","author":"Grammatico","year":"2008","journal-title":"Epidemiol Infect"},{"issue":"4","key":"bib4-20240909","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jinf.2013.11.011","article-title":"Increasing incidence of pyogenic spondylodiscitis: a 14-year population-based study","volume":"68","author":"Kehrer","year":"2014","journal-title":"J Infection"},{"issue":"1","key":"bib5-20240909","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.semarthrit.2008.03.002","article-title":"Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics","volume":"39","author":"Mylona","year":"2009","journal-title":"Semin Arthritis Rheu"},{"issue":"S1","key":"bib6-20240909","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00586-009-0979-8","article-title":"Evaluation of conservative treatment of non specific spondylodiscitis","volume":"18","author":"Bettini","year":"2009","journal-title":"Eur Spine J"},{"issue":"7","key":"bib7-20240909","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.spinee.2013.07.479","article-title":"Is posterior percutaneous screw-rod instrumentation a safe and effective alternative approach to TLSO rigid bracing for single-level pyogenic spondylodiscitis? 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