{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:17:53Z","timestamp":1793377073680,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Operative Surg.","ONSURG"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Prior treatment with magnetic resonance-guided, laser-induced thermal therapy (LITT) is widely assumed not to be a contraindication for further treatment of brain lesions, including further iterations of LITT. However, the safety and efficacy of repeat LITT treatments have never been formally investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate treatment with multiple iterations of LITT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>All patients treated with LITT at least twice at our institution were included in the study. Outcomes and neurological examinations from before and after surgery were retrospectively examined from clinic notes. Perilesonal edema was determined at various timepoints using volumetric data derived from manual tracings of fluid-attenuated inversion recovery (FLAIR) enhancement on magnetic resonance imaging (MRI). Finally, a literature review of prior cases of repeat LITT was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 9 patients underwent 18 treatments with LITT; all but 1 of whom were treated for metastatic brain lesions. One patient had a transient cerebrospinal fluid leak, whereas a second patient had a superficial wound infection, both of which resolved with standard medical care. The remaining 7 patients tolerated all LITT procedures without complication. Analysis of perilesional edema volume demonstrated a correlation with the amount of energy delivered during LITT. Literature review found 5 published papers describing 9 patients who underwent LITT more than once, the majority of whom tolerated repeat LITT well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>LITT is a safe and promising treatment modality and may be used multiple times without issue. There appears to be an association between the amount of energy delivered during a LITT session and the degree of postoperative perilesional edema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ons\/opz375","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T04:07:53Z","timestamp":1576123673000},"page":"195-204","source":"Crossref","is-referenced-by-count":18,"title":["Multiple Iterations of Magnetic Resonance-Guided Laser Interstitial Thermal Ablation of Brain Metastases: Single Surgeon's Experience and Review of the Literature"],"prefix":"10.1227","volume":"19","author":[{"given":"Daniel G","family":"Eichberg","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-1022","authenticated-orcid":false,"given":"Simon A","family":"Menaker","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J","family":"Jermakowicz","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish H","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan M","family":"Luther","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aria M","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa M","family":"Semonche","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Di","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo J","family":"Komotar","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-4989","authenticated-orcid":false,"given":"Michael E","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8]]},"reference":[{"issue":"1 Suppl 1","key":"bib1-20231031","first-page":"ONS21","article-title":"Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors","volume":"63","author":"Carpentier","year":"2008","journal-title":"Neurosurgery"},{"issue":"2","key":"bib2-20231031","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1586\/17434440.2014.882225","article-title":"Laser interstitial thermal therapy in treatment of brain tumors\u2013the NeuroBlate System","volume":"11","author":"Mohammadi","year":"2014","journal-title":"Expert Rev Med Devices"},{"issue":"Suppl 1","key":"bib3-20231031","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1227\/NEU.0000000000001446","article-title":"Laser ablation of newly diagnosed malignant gliomas: a meta-analysis","volume":"79","author":"Ivan","year":"2016","journal-title":"Neurosurgery"},{"key":"bib4-20231031","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.wneu.2016.10.037","article-title":"Magnetic resonance-guided laser ablation for the treatment of recurrent dural-based lesions: a series of five cases","volume":"98","author":"Ivan","year":"2017","journal-title":"World Neurosurg"},{"issue":"11","key":"bib5-20231031","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.3174\/ajnr.A4362","article-title":"Current applications of MRI-Guided laser interstitial thermal therapy in the treatment of brain neoplasms and epilepsy: a radiologic and neurosurgical overview","volume":"36","author":"Medvid","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"bib6-20231031","doi-asserted-by":"crossref","first-page":"e755","DOI":"10.1016\/j.wneu.2017.11.098","article-title":"Quantitative volumetric analysis following magnetic resonance-guided laser interstitial thermal ablation of cerebellar metastases","volume":"110","author":"Eichberg","year":"2018","journal-title":"World Neurosurg"},{"issue":"5","key":"bib7-20231031","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/ons\/opx029","article-title":"Visual deficit from laser interstitial thermal therapy for temporal lobe epilepsy: anatomical considerations","volume":"13","author":"Jermakowicz","year":"2017","journal-title":"Oper Neurosurg"},{"issue":"5","key":"bib8-20231031","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/epi.13715","article-title":"Laser thermal ablation for mesiotemporal epilepsy: analysis of ablation volumes and trajectories","volume":"58","author":"Jermakowicz","year":"2017","journal-title":"Epilepsia"},{"issue":"3","key":"bib9-20231031","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.media.2010.07.009","article-title":"CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy","volume":"16","author":"D\u2019Haese","year":"2012","journal-title":"Med Image Anal"},{"issue":"5","key":"bib10-20231031","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/lsm.22025","article-title":"MR-guided laser-induced thermal therapy (LITT) for recurrent glioblastomas","volume":"44","author":"Carpentier","year":"2012","journal-title":"Lasers Surg Med"},{"issue":"1 Suppl Operative","key":"bib11-20231031","first-page":"133","article-title":"Magnetic resonance thermometry-guided laser-induced thermal therapy for intracranial neoplasms: initial experience","volume":"71","author":"Jethwa","year":"2012","journal-title":"Neurosurgery"},{"issue":"6","key":"bib12-20231031","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1227\/NEU.0000000000000332","article-title":"Magnetic resonance-guided laser ablation improves local control for postradiosurgery recurrence and\/or radiation necrosis","volume":"74","author":"Rao","year":"2014","journal-title":"Neurosurgery"},{"issue":"3","key":"bib13-20231031","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3171\/jns.1995.82.3.0436","article-title":"Radiation necrosis or glioma recurrence: is computer-assisted stereotactic biopsy useful?","volume":"82","author":"Forsyth","year":"1995","journal-title":"J Neurosurg"},{"issue":"8","key":"bib14-20231031","first-page":"1967","article-title":"Radiation necrosis versus glioma recurrence: conventional MR imaging clues to diagnosis","volume":"26","author":"Mullins","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"bib15-20231031","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01.nrl.0000080951.78533.c4","article-title":"Cerebral radiation necrosis","volume":"9","author":"Giglio","year":"2003","journal-title":"Neurologist"},{"issue":"6","key":"bib16-20231031","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1227\/NEU.0000000000000343","article-title":"Real-time magnetic resonance-guided stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy","volume":"74","author":"Willie","year":"2014","journal-title":"Neurosurgery"}],"container-title":["Operative Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ons\/article-pdf\/19\/2\/195\/33491279\/opz375.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opz375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:00:42Z","timestamp":1786122042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/ons\/opz375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,12]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1093\/ons\/opz375","relation":{},"ISSN":["2332-4252","2332-4260"],"issn-type":[{"value":"2332-4252","type":"print"},{"value":"2332-4260","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,12]]}}}