{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:31:32Z","timestamp":1787009492918,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":335,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Wegener\u2019s granulomatosis is an autoimmune disease where autoantibodies target human autoantigen PR3, a serine protease locates on the neutrophil membrane. This disease affects blood small vessels and could be deadly. The origin of these autoantibodies is unknown, but infections have been implicated with autoimmune disease. In this study, we explored potential molecular mimicry between human PR3 and homologous pathogens through in silico analysis. Thirteen serine proteases from human pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Salmonella sp., Streptococcus suis, Vibrio parahaemolyticus, Bacteroides fragilis, Enterobacter ludwigii, Vibrio alginolyticus, Staphylococcus haemolyticus, Enterobacter cloacae, Escherichia coli and Pseudomonas aeruginosa) shared structural homology and amino acid sequence identity with human PR3. Epitope prediction found an only conserved epitope IVGG, located between residues 59\u201374. However, multiple alignments showed conserved regions that could be involved in cross-reactivity between human and pathogens serine proteases (90\u201398, 101\u2013108, 162\u2013169, 267 and 262 residues positions). In conclusion, this is the first report providing in silico evidence about the existence of molecular mimicry between human and pathogens serine proteases, that could explain the origins of autoantibodies found in patients suffering from Wegener\u2019s granulomatosis.<\/jats:p>","DOI":"10.1093\/oxfimm\/iqac009","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T09:49:10Z","timestamp":1669974550000},"source":"Crossref","is-referenced-by-count":4,"title":["Molecular mimicry among human proteinase 3 and bacterial antigens: implications for development of c-ANCA associated vasculitis"],"prefix":"10.1093","volume":"3","author":[{"given":"Y","family":"Chavez","sequence":"first","affiliation":[{"name":"Medical Research Group (GINUMED) Universitary Corporation Rafael Nu\u00f1ez, Centro Calle de la Soledad No. 5\u201370, Cartagena 130002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Garces","sequence":"additional","affiliation":[{"name":"Medical Research Group (GINUMED) Universitary Corporation Rafael Nu\u00f1ez , Centro Calle de la Soledad No. 5\u201370, Cartagena 130002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Medical Research Group (GINUMED) Universitary Corporation Rafael Nu\u00f1ez , Centro Calle de la Soledad No. 5\u201370, Cartagena 130002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Escobar","sequence":"additional","affiliation":[{"name":"Catholic University of Manizales , Manizales, Av. Santander #No. 60, Manizales, Caldas 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Medical Research Group (GINUMED) Universitary Corporation Rafael Nu\u00f1ez , Centro Calle de la Soledad No. 5\u201370, Cartagena 130002, Colombia"},{"name":"University of Antioquia Group of Clinical and Experimental Allergy (GACE), IPS Universitaria, , Cl 77 y 78 al norte, Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Buend\u00eda","sequence":"additional","affiliation":[{"name":"University of Cartagena Faculty of Medicine, , Cra. 50 #24120, Zaragocilla, Cartagena de Indias, Provincia de Cartagena, Bol\u00edvar, Cartagena 130014, Colombia"},{"name":"University of Cartagena Clinical and Biomedical Research Group, Faculty of Medicine, , Cra. 50 #24120, Zaragocilla, Cartagena de Indias, Provincia de Cartagena, Bol\u00edvar, Cartagena 130014, Colombia"},{"name":"Serena del Mar Hospital Center , VIA AL MAR KM 8, Cartagena de Indias, Provincia de Cartagena, Bol\u00edvar, Cartagena 130008, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-0541","authenticated-orcid":false,"given":"M","family":"M\u00fanera","sequence":"additional","affiliation":[{"name":"Universitary Corporation Rafael Nu\u00f1ez, Centro Medical Research Group (GINUMED) Calle de la Soledad No. 5\u201370, Cartagena 130002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"2023011714432223300_iqac009-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2008.03834.x","article-title":"The role of infections in autoimmune disease","volume":"155","author":"Ercolini","year":"2009","journal-title":"Clin Exp 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