{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:45:15Z","timestamp":1790070315443,"version":"4.0.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":154,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sir Halley Stewart","award":["1065"],"award-info":[{"award-number":["1065"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glycocalyx disruption and hyperinflammatory responses are implicated in the pathogenesis of dengue-associated vascular leak, however little is known about their association with clinical outcomes of patients with dengue shock syndrome (DSS). We investigated the association of vascular and inflammatory biomarkers with clinical outcomes and their correlations with clinical markers of vascular leakage. We performed a prospective cohort study in Viet Nam. Children \u22655\u2009years of age with a clinical diagnosis of DSS were enrolled into this study. Blood samples were taken daily during ICU stay and 7\u201310\u2009days after hospital discharge for measurements of plasma levels of Syndecan-1, Hyaluronan, Suppression of tumourigenicity 2 (ST-2), Ferritin, N-terminal pro Brain Natriuretic Peptide (NT-proBNP), and Atrial Natriuretic Peptide (ANP). The primary outcome was recurrent shock. Ninety DSS patients were enrolled. Recurrent shock occurred in 16 patients. All biomarkers, except NT-proBNP, were elevated at presentation with shock. There were no differences between compensated and decompensated DSS patients. Glycocalyx markers were positively correlated with inflammatory biomarkers, haematocrit, percentage haemoconcentration, and negatively correlated with stroke volume index. While Syndecan-1, Hyaluronan, Ferritin, and ST-2 improved with time, ANP continued to be raised at follow-up. Enrolment Syndecan-1 levels were observed to be associated with developing recurrent shock although the association did not reach the statistical significance at the P\u2009&amp;lt;\u20090.01 (OR\u2009=\u20091.82, 95% CI 1.07\u20133.35, P\u2009=\u20090.038). Cardiovascular and inflammatory biomarkers are elevated in DSS, correlate with clinical vascular leakage parameters and follow different kinetics over time. Syndecan-1 may have potential utility in risk stratifying DSS patients in ICU.<\/jats:p>","DOI":"10.1093\/oxfimm\/iqae005","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:51:03Z","timestamp":1717447863000},"source":"Crossref","is-referenced-by-count":8,"title":["Kinetics of cardiovascular and inflammatory biomarkers in paediatric dengue shock syndrome"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-0868","authenticated-orcid":false,"given":"Ho Quang","family":"Chanh","sequence":"first","affiliation":[{"name":"Oxford University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Trung","family":"Trieu","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"},{"name":"Hospital for Tropical Diseases , Ho Chi Minh City, Viet 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University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Thi Le","family":"Duyen","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan","family":"Nguyen-Lyle","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Lam","family":"Vuong","sequence":"additional","affiliation":[{"name":"Oxford University Clinical Research Unit , Ho Chi Minh City, 72707, Viet Nam"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City , Ho Chi Minh City, Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phung Khanh","family":"Lam","sequence":"additional","affiliation":[{"name":"Oxford University Clinical 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