{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:30:54Z","timestamp":1777523454490,"version":"3.51.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,4]]},"DOI":"10.1093\/pch\/20.8.451","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T02:51:29Z","timestamp":1486608689000},"page":"451-456","source":"Crossref","is-referenced-by-count":25,"title":["Minimizing blood loss and the need for transfusions in very premature infants"],"prefix":"10.1093","volume":"20","author":[{"given":"Brigitte","family":"Lemyre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Sample","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lacaze-Masmonteil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Canadian Paediatric Society","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Fetus and Newborn Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,4]]},"reference":[{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref1","first-page":"400","article-title":"Blood cell counting in neonates: A comparison between a low volume micromethod and the standard laboratory method","volume":"9","author":"Papa","year":"2011","journal-title":"Blood Transfus"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0955-3886(99)00067-3","article-title":"Transfusion associated graft-versus-host disease, cytomegalovirus infection and HLA alloimmunization in neonatal and pediatric patients","volume":"21","author":"Hume","year":"1999","journal-title":"Transfus Sci"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jpeds.2011.02.040","article-title":"Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants","volume":"159","author":"dos Santos","year":"2011","journal-title":"J Pediatr"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1542\/peds.2010-3178","article-title":"Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants","volume":"127","author":"Paul","year":"2011","journal-title":"Pediatrics"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1542\/peds.2011-2872","article-title":"Transfusion associated necrotizing enterocolitis: A meta-analysis of observational data","volume":"129","author":"Mohamed","year":"2012","journal-title":"Pediatrics"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jpeds.2014.06.012","article-title":"Red blood cell transfusion is not associated with necrotizing enterocolitis: A review of consecutive transfusions in a tertiary neonatal intensive care unit","volume":"165","author":"Wallenstein","year":"2014","journal-title":"J Pediatr"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1542\/peds.106.5.1070","article-title":"Variations in practice and outcomes in the Canadian NICU network: 1996\u20131997","volume":"106","author":"Lee","year":"2000","journal-title":"Pediatrics"},{"issue":"1\u20132","key":"key\n\t\t\t\t20180328154905_ref8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cca.2011.10.027","article-title":"Implementation of a multi-parameter point-of-care-blood test analyzer reduces central laboratory testing and need for blood transfusions in very low birth weight infants","volume":"413","author":"Mahieu","year":"2012","journal-title":"Clin Chim Acta"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1537-2995.2009.02373.x","article-title":"Variability on red blood cell transfusion practices among Brazilian neonatal intensive care units","volume":"50","author":"dos Santos","year":"2010","journal-title":"Transfusion"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1423-0410.2008.01072.x","article-title":"A very strict guideline reduces the number of erythrocyte transfusions in preterm infants","volume":"95","author":"Mimica","year":"2008","journal-title":"Vox Sang"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.jp.7211201","article-title":"Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants","volume":"25","author":"Madan","year":"2005","journal-title":"J Perinatol"},{"key":"key\n\t\t\t\t20180328154905_ref12","unstructured":"Oxford Centre for Evidence-Based Medicine 2014: http:\/\/www.cebm.net (Accessed July 31, 2014)."},{"issue":"6","key":"key\n\t\t\t\t20180328154905_ref13","first-page":"348","article-title":"Developing clinical guidelines","volume":"170","author":"Shekelle","year":"1999","journal-title":"West J Med"},{"key":"key\n\t\t\t\t20180328154905_ref14","first-page":"CD003248","article-title":"Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes","volume":"8","author":"Rabe","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/trf.12469","article-title":"Effects of placental transfusion in extremely low birthweight infants: Meta-analysis of long- and short-term outcomes. [Review]","volume":"54","author":"Ghavam","year":"2014","journal-title":"Transfusion"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref16","doi-asserted-by":"crossref","first-page":"F14","DOI":"10.1136\/adc.2006.108902","article-title":"Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks\u2019 gestation: A randomised controlled trial","volume":"93","author":"Hosono","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"10","key":"key\n\t\t\t\t20180328154905_ref17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/jp.2013.70","article-title":"The effects of umbilical cord milking in extremely preterm infants: A randomized controlled trial","volume":"33","author":"March","year":"2013","journal-title":"J Perinatol"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref18","doi-asserted-by":"crossref","first-page":"519.e1","DOI":"10.1016\/j.ajog.2014.05.037","article-title":"Effect of umbilical cord milking on morbidity and survival in extremely low gestational age neonates","volume":"21","author":"Patel","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"8","key":"key\n\t\t\t\t20180328154905_ref19","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1097\/MPH.0000000000000143","article-title":"Effects of umbilical cord milking on the need for packed red blood cell transfusions and early neonatal hemodynamic adaptation in preterm infants born ?1500 g: A prospective, randomized, controlled trial","volume":"36","author":"Alan","year":"2014","journal-title":"J Pediatr Hematol Oncol"},{"issue":"2 Pt 1","key":"key\n\t\t\t\t20180328154905_ref20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/AOG.0b013e3181fe46ff","article-title":"Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: A randomized controlled trial","volume":"117","author":"Rabe","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"11","key":"key\n\t\t\t\t20180328154905_ref21","first-page":"CD000512","article-title":"Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants","author":"Whyte","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jpeds.2006.05.011","article-title":"The Premature Infants in Need of Transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants","volume":"149","author":"Kirpalani","year":"2006","journal-title":"J Pediatr"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jpc.12409","article-title":"Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: A systematic review and meta-analysis","volume":"50","author":"Ibrahim","year":"2014","journal-title":"J Paediatr Child Health"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1542\/peds.2008-0338","article-title":"Neurodevelopmental outcome of extremely low-birth-weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion","volume":"123","author":"Whyte","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref25","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/08035250510027291","article-title":"A comparison of high and standard blood transfusion volumes in premature infants","volume":"94","author":"Wong","year":"2005","journal-title":"Acta Paediatr"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00043426-200201000-00012","article-title":"Transfusion volume in infants with very low birth weight: A randomized trial of 10 versus 20 ml\/kg","volume":"24","author":"Paul","year":"2002","journal-title":"J Pediatr Hematol Oncol"},{"key":"key\n\t\t\t\t20180328154905_ref27","first-page":"CD004863","article-title":"Early erythropoietin for preventing red blood cell transfusion in preterm and\/or low birth weight infants","volume":"4","author":"Ohlsson","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180328154905_ref28","first-page":"CD004868","article-title":"Late erythropoietin for preventing red blood cell transfusion in preterm and\/or low birth weight infants","volume":"4","author":"Aher","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180328154905_ref29","first-page":"CD004865","article-title":"Early versus late erythropoietin for preventing red blood cell transfusion in preterm and\/or low birth weight infants","volume":"10","author":"Aher","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"8","key":"key\n\t\t\t\t20180328154905_ref30","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/08880010500278715","article-title":"Stepping up versus standard doses of erythropoietin in preterm infants: A randomized controlled trial","volume":"22","author":"Gumy-Pause","year":"2005","journal-title":"Pediatr Hematol Oncol"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref31","first-page":"178","article-title":"Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity","volume":"14","author":"Saeidi","year":"2012","journal-title":"Iranian Red Crescent Med J"},{"issue":"6","key":"key\n\t\t\t\t20180328154905_ref32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/apa.12193","article-title":"","volume":"102","author":"Costa","year":"2013","journal-title":"Acta Paediatr"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref33","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1542\/peds.2013-0143","article-title":"A randomized, masked, placebo controlled study of darbepoetin alfa in preterm infants","volume":"132","author":"Ohls","year":"2013","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180328154905_ref34","first-page":"CD005095","article-title":"Enteral iron supplementation in preterm and low birth weight infants","volume":"3","author":"Mills","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180328154905_ref35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2431-12-99","article-title":"Benefits of iron supplementation for low birth weight infants: A systematic review","volume":"12","author":"Long","year":"2012","journal-title":"BMC Pediatr"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref36","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1542\/peds.106.4.700","article-title":"Prospective randomized trial of early versus late enteral iron supplementation in infants with a birth weight of less than 1301 grams","volume":"106","author":"Franz","year":"2000","journal-title":"Pediatrics"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref37","doi-asserted-by":"crossref","first-page":"e433","DOI":"10.1542\/peds.2012-1822","article-title":"Randomized trial of iron supplementation versus routine iron intake in VLBW infants","volume":"131","author":"Taylor","year":"2013","journal-title":"Pediatrics"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref38","doi-asserted-by":"crossref","first-page":"F105","DOI":"10.1136\/archdischild-2013-304650","article-title":"Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: A randomised controlled trial","volume":"99","author":"Joy","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"key\n\t\t\t\t20180328154905_ref39","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1442-200x.2004.01979.x","article-title":"Oral iron supplementation in preterm infants treated with erythropoietin","volume":"46","author":"Fujiu","year":"2004","journal-title":"Pediatr Int"},{"issue":"11","key":"key\n\t\t\t\t20180328154905_ref40","first-page":"1765","article-title":"Nutrient needs and feeding of premature infants","volume":"152","author":"Nutrition Committee, Canadian Paediatric Society","year":"1995","journal-title":"CMAJ"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref41","first-page":"20","article-title":"","volume":"43","author":"Amuchou","year":"2006","journal-title":"Indian Pediatr"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref42","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ppul.22593","article-title":"Sidestream microstream end tidal carbon dioxide measurements and blood gas correlations in neonatal intensive care unit","volume":"48","author":"Singh","year":"2013","journal-title":"Pediatr Pulmonol"},{"issue":"4 Pt 1","key":"key\n\t\t\t\t20180328154905_ref43","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1542\/peds.101.4.648","article-title":"Mainstream end-tidal carbon dioxide monitoring in the neonatal intensive care unit","volume":"101","author":"Rozycki","year":"1998","journal-title":"Pediatrics"},{"issue":"3","key":"key\n\t\t\t\t20180328154905_ref44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02845211","article-title":"End tidal carbon dioxide monitoring-its reliability in neonates","volume":"64","author":"Nangia","year":"1997","journal-title":"Indian J Pediatr"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1651-2227.2011.02164.x","article-title":"Transcutaneous blood gas monitoring during neonatal intensive care","volume":"100","author":"Sandberg","year":"2011","journal-title":"Acta Paediatr"},{"issue":"11","key":"key\n\t\t\t\t20180328154905_ref46","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1007\/s00134-009-1647-5","article-title":"Detection of carbon dioxide thresholds using low-flow sidestream capnography in ventilated preterm infants","volume":"35","author":"Lopez","year":"2009","journal-title":"Intensive Care Med"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref47","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1542\/peds.2013-1713","article-title":"Reliability of transcutaneous bilirubin devices in preterm infants: A systematic review","volume":"132","author":"Nagar","year":"2013","journal-title":"Pediatrics"},{"issue":"8","key":"key\n\t\t\t\t20180328154905_ref48","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/jp.2015.12","article-title":"Validation of noninvasive hemoglobin measurement by pulse co-oximeter in newborn infants","volume":"35","author":"Nicholas","year":"2015","journal-title":"J Perinatol"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000261019","article-title":"Spectroscopic noninvasive measurement of hemoglobin compared with capillary and venous values in neonates","volume":"98","author":"Rabe","year":"2010","journal-title":"Neonatology"},{"issue":"1","key":"key\n\t\t\t\t20180328154905_ref50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/PCC.0b013e318260117d","article-title":"The efficacy of noninvasive hemoglobin measurement by pulse CO-oximetry in neonates","volume":"14","author":"Jung","year":"2013","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref51","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1542\/peds.2004-1680","article-title":"Reduction in red blood cell transfusions among preterm infants: Results of a randomized trial with an in-line blood gas and chemistry monitor","volume":"115","author":"Widness","year":"2005","journal-title":"Pediatrics"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000047153","article-title":"The effects of bedside blood gas monitoring on blood loss and ventilator management","volume":"80","author":"Moya","year":"2001","journal-title":"Biol Neonate"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref53","doi-asserted-by":"crossref","first-page":"F136","DOI":"10.1136\/archdischild-2012-301661","article-title":"Validation of the continuous glucose monitoring sensor in preterm infants","volume":"98","author":"Beardsall","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"key\n\t\t\t\t20180328154905_ref54","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1542\/peds.108.5.1187","article-title":"Glucose monitoring with long-term subcutaneous microdialysis in neonates","volume":"108","author":"Baumeister","year":"2001","journal-title":"Pediatrics"},{"issue":"4","key":"key\n\t\t\t\t20180328154905_ref55","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1053\/j.semperi.2012.04.003","article-title":"Nonpharmacological, blood conservation techniques for preventing neonatal anemia\u2013effective and promising strategies for reducing transfusion","volume":"36","author":"Carroll","year":"2012","journal-title":"Semin Perinatol"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref56","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1542\/peds.101.2.194","article-title":"Variations in transfusion practice in neonatal intensive care","volume":"101","author":"Ringer","year":"1998","journal-title":"Pediatrics"},{"issue":"2","key":"key\n\t\t\t\t20180328154905_ref57","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1542\/peds.106.2.e19","article-title":"Phlebotomy overdraw in the neonatal intensive care nursery","volume":"106","author":"Lin","year":"2000","journal-title":"Pediatrics"}],"container-title":["Paediatrics & Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article\/20\/8\/451\/2647349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T02:50:54Z","timestamp":1522291854000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/20\/8\/451\/2647349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,4]]},"references-count":57,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,12,4]]},"published-print":{"date-parts":[[2015,12,4]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/20.8.451","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,12,4]]},"published":{"date-parts":[[2015,12,4]]}}}