{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:28:25Z","timestamp":1761017305301},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare effectiveness and safety of combination therapy (acetaminophen and ibuprofen) to monotherapy (ibuprofen, indomethacin, or acetaminophen alone) in treatment of the patent ductus arteriosus (PDA) in premature neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective cohort study of neonates admitted to a tertiary-level neonatal intensive care unit. Included neonates were born at &amp;lt;32 weeks gestation and received pharmacotherapy for PDA closure. Based on the primary therapy received, our cohort was divided into the following four groups: indomethacin alone, ibuprofen alone, acetaminophen alone, and ibuprofen and acetaminophen (in combination). Baseline characteristics, effectiveness, safety, neonatal mortality, and morbidities rates between these groups were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred and forty neonates were analyzed; 17 received combination therapy, and 123 neonates received monotherapy: 22 (17.9%) ibuprofen, 29 (23.6%) acetaminophen, and 72 (58.5%) indomethacin. The PDA closure rates were 41.7% for indomethacin, 41.2% for combination therapy, 37.9% for acetaminophen, and 31.8% for ibuprofen (P=0.100). Rates of adverse effects were comparable between the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The rate of ductal closure was not different between combination therapy and monotherapy. The study did not demonstrate any increased adverse effects in the combination group. Future well-designed prospective clinical trials are needed to guide clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pch\/pxaa057","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T10:58:12Z","timestamp":1590058692000},"page":"e177-e183","source":"Crossref","is-referenced-by-count":12,"title":["Use of combination therapy with acetaminophen and ibuprofen for closure of the patent ductus arteriosus in preterm neonates"],"prefix":"10.1093","volume":"26","author":[{"given":"Susan","family":"Kimani","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Western University, London, Ontario"},{"name":"Children\u2019s hospital, London Health Sciences Centre, London, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimann","family":"Surak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Western University, London, Ontario"},{"name":"Children\u2019s hospital, London Health Sciences Centre, London, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Western University, London, Ontario"},{"name":"Children\u2019s Health Research Institute, London, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soume","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Western University, London, Ontario"},{"name":"Children\u2019s hospital, London Health Sciences Centre, London, Ontario"},{"name":"Children\u2019s Health Research Institute, London, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"issue":"11","key":"2021061115002149600_CIT0001","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.acvd.2010.06.006","article-title":"The ductus arteriosus: physiology, 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